Chlorine in PDB 7qne: Cryo-Em Structure of Human Full-Length Synaptic ALPHA1BETA3GAMMA2 Gaba(A)R in Complex with RO15-4513 and Megabody MB38

The binding sites of Chlorine atom in the Cryo-Em Structure of Human Full-Length Synaptic ALPHA1BETA3GAMMA2 Gaba(A)R in Complex with RO15-4513 and Megabody MB38 (pdb code 7qne). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Cryo-Em Structure of Human Full-Length Synaptic ALPHA1BETA3GAMMA2 Gaba(A)R in Complex with RO15-4513 and Megabody MB38, PDB code: 7qne:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Cryo-Em Structure of Human Full-Length Synaptic ALPHA1BETA3GAMMA2 Gaba(A)R in Complex with RO15-4513 and Megabody MB38


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Human Full-Length Synaptic ALPHA1BETA3GAMMA2 Gaba(A)R in Complex with RO15-4513 and Megabody MB38 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl504 b:53.5 occ:1.00 N A:ASN189 3.3 41.8 1.0 N A:VAL53 3.5 37.6 1.0 CG A:GLN190 3.5 40.8 1.0 N A:GLN190 3.7 40.8 1.0 O A:VAL53 3.7 37.6 1.0 CA A:LEU188 3.9 38.0 1.0 NE2 A:GLN190 3.9 40.8 1.0 CD2 A:TYR191 4.1 36.9 1.0 C A:LEU188 4.1 38.0 1.0 CD2 A:LEU188 4.1 38.0 1.0 CB A:LEU188 4.2 38.0 1.0 CB A:VAL53 4.2 37.6 1.0 CA A:PRO52 4.2 34.7 1.0 CA A:ASN189 4.2 41.8 1.0 CA A:VAL53 4.2 37.6 1.0 CD A:GLN190 4.3 40.8 1.0 C A:PRO52 4.4 34.7 1.0 CB A:ASN189 4.4 41.8 1.0 C A:VAL53 4.4 37.6 1.0 OD1 A:ASN189 4.5 41.8 1.0 C A:ASN189 4.5 41.8 1.0 CB A:GLN190 4.6 40.8 1.0 CA A:GLN190 4.6 40.8 1.0 N A:TYR191 4.6 36.9 1.0 CB A:PRO52 4.7 34.7 1.0 CE2 A:TYR191 4.7 36.9 1.0 CG A:ASN189 4.8 41.8 1.0 CG2 A:VAL53 4.8 37.6 1.0 CG A:LEU188 4.8 38.0 1.0 O A:ARG187 4.9 39.0 1.0

Chlorine binding site 2 out of 3 in the Cryo-Em Structure of Human Full-Length Synaptic ALPHA1BETA3GAMMA2 Gaba(A)R in Complex with RO15-4513 and Megabody MB38


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of Human Full-Length Synaptic ALPHA1BETA3GAMMA2 Gaba(A)R in Complex with RO15-4513 and Megabody MB38 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl501 b:54.8 occ:1.00 N C:VAL65 3.2 41.6 1.0 N C:GLN200 3.4 53.8 1.0 N C:TYR199 3.5 52.9 1.0 CD1 C:PHE201 3.7 47.7 1.0 CA C:LEU198 3.8 46.1 1.0 CB C:VAL65 3.8 41.6 1.0 CA C:PRO64 3.8 40.6 1.0 CG2 C:VAL65 3.9 41.6 1.0 C C:LEU198 3.9 46.1 1.0 CB C:GLN200 3.9 53.8 1.0 C C:PRO64 4.0 40.6 1.0 CA C:VAL65 4.0 41.6 1.0 O C:ARG197 4.0 45.8 1.0 CD2 C:LEU198 4.0 46.1 1.0 CA C:GLN200 4.1 53.8 1.0 N C:PHE201 4.2 47.7 1.0 CE1 C:PHE201 4.4 47.7 1.0 CA C:TYR199 4.4 52.9 1.0 C C:TYR199 4.4 52.9 1.0 CG C:GLN200 4.4 53.8 1.0 O C:VAL65 4.4 41.6 1.0 CD2 C:TYR199 4.5 52.9 1.0 CB C:LEU198 4.6 46.1 1.0 CB C:PRO64 4.6 40.6 1.0 C C:GLN200 4.6 53.8 1.0 C C:VAL65 4.7 41.6 1.0 O C:GLY63 4.7 37.8 1.0 CB C:TYR199 4.7 52.9 1.0 CG C:PHE201 4.7 47.7 1.0 CB C:PHE201 4.8 47.7 1.0 CG C:TYR199 4.8 52.9 1.0 N C:LEU198 4.8 46.1 1.0 O C:LEU198 4.9 46.1 1.0 C C:ARG197 4.9 45.8 1.0 CG C:LEU198 5.0 46.1 1.0 N C:PRO64 5.0 40.6 1.0

Chlorine binding site 3 out of 3 in the Cryo-Em Structure of Human Full-Length Synaptic ALPHA1BETA3GAMMA2 Gaba(A)R in Complex with RO15-4513 and Megabody MB38


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cryo-Em Structure of Human Full-Length Synaptic ALPHA1BETA3GAMMA2 Gaba(A)R in Complex with RO15-4513 and Megabody MB38 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl501 b:60.2 occ:1.00 CG D:GLN190 3.4 48.1 1.0 N D:VAL53 3.6 44.9 1.0 N D:ASN189 3.6 48.5 1.0 O D:VAL53 3.6 44.9 1.0 N D:GLN190 3.7 48.1 1.0 CD2 D:TYR191 3.7 45.0 1.0 CB D:VAL53 4.0 44.9 1.0 OE1 D:GLN190 4.0 48.1 1.0 CA D:VAL53 4.2 44.9 1.0 CD D:GLN190 4.2 48.1 1.0 CD2 D:LEU188 4.2 42.1 1.0 CA D:LEU188 4.2 42.1 1.0 C D:VAL53 4.4 44.9 1.0 CE2 D:TYR191 4.4 45.0 1.0 C D:LEU188 4.4 42.1 1.0 CA D:ASN189 4.4 48.5 1.0 CB D:GLN190 4.5 48.1 1.0 CA D:GLN190 4.5 48.1 1.0 CB D:ASN189 4.6 48.5 1.0 CA D:PRO52 4.6 39.7 1.0 N D:TYR191 4.6 45.0 1.0 C D:PRO52 4.6 39.7 1.0 C D:ASN189 4.6 48.5 1.0 CB D:LEU188 4.6 42.1 1.0 CG2 D:VAL53 4.7 44.9 1.0 CG D:TYR191 4.7 45.0 1.0 C D:GLN190 4.8 48.1 1.0 CB D:TYR191 4.8 45.0 1.0

A.Sente, R.Desai, K.Naydenova, T.Malinauskas, Y.Jounaidi, J.Miehling, X.Zhou, S.Masiulis, S.W.Hardwick, D.Y.Chirgadze, K.W.Miller, A.R.Aricescu. Differential Assembly Diversifies Gaba A Receptor Structures and Signalling. Nature V. 604 190 2022.
ISSN: ESSN 1476-4687
PubMed: 35355020
DOI: 10.1038/S41586-022-04517-3