Chlorine in PDB 7r4g: Bovine Complex I in the Presence of IM1761092, Slack Class II (Composite Map)

All present enzymatic activity of Bovine Complex I in the Presence of IM1761092, Slack Class II (Composite Map):
1.6.5.3; 1.6.99.3; 7.1.1.2;

The structure of Bovine Complex I in the Presence of IM1761092, Slack Class II (Composite Map) also contains other interesting chemical elements:

Iron	(Fe)	28 atoms
Zinc	(Zn)	1 atom
Magnesium	(Mg)	1 atom
Potassium	(K)	1 atom
Iodine	(I)	2 atoms

The binding sites of Chlorine atom in the Bovine Complex I in the Presence of IM1761092, Slack Class II (Composite Map) (pdb code 7r4g). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Bovine Complex I in the Presence of IM1761092, Slack Class II (Composite Map), PDB code: 7r4g:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Bovine Complex I in the Presence of IM1761092, Slack Class II (Composite Map)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Bovine Complex I in the Presence of IM1761092, Slack Class II (Composite Map) within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl403 b:63.0 occ:1.00 CL01 H:I49403 0.0 63.0 1.0 C12 H:I49403 1.7 63.0 1.0 C13 H:I49403 2.7 63.0 1.0 C10 H:I49403 2.7 63.0 1.0 O H:PRO48 3.1 47.4 1.0 I02 H:I49403 3.3 63.0 1.0 CA H:PRO48 3.7 47.4 1.0 C H:PRO48 3.8 47.4 1.0 CB H:PRO48 3.8 47.4 1.0 O H:ALA18 3.9 47.0 1.0 CA H:ALA18 3.9 47.0 1.0 CB H:ALA18 3.9 47.0 1.0 C07 H:I49403 4.0 63.0 1.0 C11 H:I49403 4.0 63.0 1.0 OG1 H:THR21 4.0 49.1 1.0 CB H:ALA52 4.3 50.4 1.0 N H:ALA52 4.3 50.4 1.0 C H:ALA18 4.4 47.0 1.0 CB H:ASP51 4.5 50.6 1.0 C09 H:I49403 4.5 63.0 1.0 CA H:ALA52 4.6 50.4 1.0 CG2 H:THR21 4.6 49.1 1.0 CB H:THR21 4.9 49.1 1.0 N H:ILE49 5.0 48.0 1.0 CG H:PRO48 5.0 47.4 1.0

Chlorine binding site 2 out of 2 in the Bovine Complex I in the Presence of IM1761092, Slack Class II (Composite Map)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Bovine Complex I in the Presence of IM1761092, Slack Class II (Composite Map) within 5.0Å range: probe atom residue distance (Å) B Occ N:Cl1305 b:66.9 occ:1.00 CL01 N:I491305 0.0 66.9 1.0 C12 N:I491305 1.7 66.9 1.0 C10 N:I491305 2.7 66.9 1.0 C13 N:I491305 2.7 66.9 1.0 I02 N:I491305 3.4 66.9 1.0 CA d:ARG86 3.9 56.0 1.0 CB d:ARG86 3.9 56.0 1.0 C07 N:I491305 4.0 66.9 1.0 C11 N:I491305 4.0 66.9 1.0 N d:ARG86 4.0 56.0 1.0 NE1 h:TRP122 4.1 58.0 1.0 O d:MET82 4.2 55.9 1.0 CG1 d:VAL85 4.2 57.3 1.0 OD2 d:ASP89 4.5 58.5 1.0 C09 N:I491305 4.5 66.9 1.0 C d:VAL85 4.6 57.3 1.0 OE1 N:GLU347 4.6 57.1 1.0 CG d:ARG86 4.6 56.0 1.0 CE2 h:TRP122 4.7 58.0 1.0 CD1 h:TRP122 4.7 58.0 1.0 CG N:GLU347 4.8 57.1 1.0 CB d:VAL85 4.8 57.3 1.0 CD N:GLU347 4.8 57.1 1.0 CB N:GLU347 4.9 57.1 1.0 CZ2 h:TRP122 5.0 58.0 1.0 O d:VAL85 5.0 57.3 1.0

H.R.Bridges, J.N.Blaza, Z.Yin, I.Chung, M.N.Pollak, J.Hirst. Structural Basis of Mammalian Respiratory Complex I Inhibition By Medicinal Biguanides. Science V. 379 351 2023.
ISSN: ESSN 1095-9203
PubMed: 36701435
DOI: 10.1126/SCIENCE.ADE3332