Chlorine in PDB 7sr6: Human Endogenous Retrovirus (Herv-K) Reverse Transcriptase Ternary Complex with Dsdna Template Primer and Dntp

The structure of Human Endogenous Retrovirus (Herv-K) Reverse Transcriptase Ternary Complex with Dsdna Template Primer and Dntp, PDB code: 7sr6 was solved by E.T.Baldwin, C.Nichols, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	88.85 / 2.62
Space group	P 31
Cell size a, b, c (Å), α, β, γ (°)	177.697, 177.697, 117.414, 90, 90, 120
R / Rfree (%)	16.8 / 21.8

The structure of Human Endogenous Retrovirus (Herv-K) Reverse Transcriptase Ternary Complex with Dsdna Template Primer and Dntp also contains other interesting chemical elements:

Magnesium	(Mg)	5 atoms
Potassium	(K)	11 atoms

The binding sites of Chlorine atom in the Human Endogenous Retrovirus (Herv-K) Reverse Transcriptase Ternary Complex with Dsdna Template Primer and Dntp (pdb code 7sr6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human Endogenous Retrovirus (Herv-K) Reverse Transcriptase Ternary Complex with Dsdna Template Primer and Dntp, PDB code: 7sr6:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Human Endogenous Retrovirus (Herv-K) Reverse Transcriptase Ternary Complex with Dsdna Template Primer and Dntp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Endogenous Retrovirus (Herv-K) Reverse Transcriptase Ternary Complex with Dsdna Template Primer and Dntp within 5.0Å range: probe atom residue distance (Å) B Occ F:Cl620 b:85.8 occ:1.00 NH2 F:ARG296 4.0 70.2 1.0 O F:HIS365 4.1 69.3 1.0 O F:ILE532 4.1 52.6 1.0 CB F:TYR534 4.4 71.4 1.0 N F:TYR534 4.4 67.8 1.0 NE2 F:HIS365 4.5 60.1 1.0 CE1 F:HIS365 4.6 57.0 1.0 CD1 F:LEU531 4.7 44.4 1.0 NE2 F:HIS345 4.9 58.8 1.0 CA F:TYR534 4.9 71.0 1.0 CD2 F:HIS345 5.0 51.5 1.0 CD2 F:HIS365 5.0 57.5 1.0

Chlorine binding site 2 out of 2 in the Human Endogenous Retrovirus (Herv-K) Reverse Transcriptase Ternary Complex with Dsdna Template Primer and Dntp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Endogenous Retrovirus (Herv-K) Reverse Transcriptase Ternary Complex with Dsdna Template Primer and Dntp within 5.0Å range: probe atom residue distance (Å) B Occ G:Cl608 b:71.3 occ:1.00 N G:LYS258 3.5 71.7 1.0 CB G:LYS258 3.9 66.6 1.0 CG2 G:ILE449 4.0 69.7 1.0 CA G:ARG257 4.2 73.1 1.0 O G:ILE256 4.2 88.8 1.0 CA G:LYS258 4.2 69.3 1.0 OE1 G:GLU255 4.3 67.8 1.0 C G:ARG257 4.3 64.6 1.0 NZ G:LYS258 4.4 73.1 1.0 CG G:LYS258 4.5 65.0 1.0 N G:ASP259 4.5 71.0 1.0 CD G:LYS258 4.8 64.1 1.0 C G:LYS258 4.8 63.5 1.0 CG G:ARG257 4.9 88.2 1.0

E.T.Baldwin, M.Gotte, E.P.Tchesnokov, E.Arnold, M.Hagel, C.Nichols, P.Dossang, M.Lamers, P.Wan, S.Steinbacher, D.L.Romero. Human Endogenous Retrovirus-K (Herv-K) Reverse Transcriptase (Rt) Structure and Biochemistry Reveals Remarkable Similarities to Hiv-1 Rt and Opportunities For Herv-K-Specific Inhibition. Proc.Natl.Acad.Sci.Usa V. 119 60119 2022.
ISSN: ESSN 1091-6490
PubMed: 35771941
DOI: 10.1073/PNAS.2200260119