Atomistry » Chlorine » PDB 7uje-7ux4 » 7uvn
Atomistry »
  Chlorine »
    PDB 7uje-7ux4 »
      7uvn »

Chlorine in PDB 7uvn: Crystal Structure of Human Clpp Protease in Complex with Tr-57

Enzymatic activity of Crystal Structure of Human Clpp Protease in Complex with Tr-57

All present enzymatic activity of Crystal Structure of Human Clpp Protease in Complex with Tr-57:
3.4.21.92;

Protein crystallography data

The structure of Crystal Structure of Human Clpp Protease in Complex with Tr-57, PDB code: 7uvn was solved by M.F.Mabanglo, W.A.Houry, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.25 / 3.11
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 142.098, 153.04, 104.696, 90, 117.92, 90
R / Rfree (%) 22.9 / 28.3

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Clpp Protease in Complex with Tr-57 (pdb code 7uvn). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 7 binding sites of Chlorine where determined in the Crystal Structure of Human Clpp Protease in Complex with Tr-57, PDB code: 7uvn:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7;

Chlorine binding site 1 out of 7 in 7uvn

Go back to Chlorine Binding Sites List in 7uvn
Chlorine binding site 1 out of 7 in the Crystal Structure of Human Clpp Protease in Complex with Tr-57


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Clpp Protease in Complex with Tr-57 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl301

b:70.7
occ:1.00
 CL01 A:P3O301 0.0 70.7 1.0
C02 A:P3O301 1.8 56.6 1.0
C03 A:P3O301 2.8 52.1 1.0
C30 A:P3O301 2.8 53.1 1.0
CG A:ARG78 3.4 54.5 1.0
CB G:PHE105 3.5 46.1 1.0
CD1 G:PHE105 3.5 50.0 1.0
CD2 A:LEU79 3.6 45.9 1.0
CA G:PHE105 3.8 46.4 1.0
CG G:PHE105 4.0 52.0 1.0
C04 A:P3O301 4.0 51.6 1.0
C29 A:P3O301 4.1 52.3 1.0
O A:ARG78 4.1 52.7 1.0
C A:ARG78 4.2 54.8 1.0
NH1 A:ARG78 4.2 52.1 1.0
CB A:ARG78 4.2 54.0 1.0
N A:LEU79 4.3 59.6 1.0
N G:PHE105 4.4 48.6 1.0
CZ A:ARG78 4.4 58.1 1.0
CA A:LEU79 4.4 54.7 1.0
NE A:ARG78 4.5 60.4 1.0
CD A:ARG78 4.5 56.9 1.0
C05 A:P3O301 4.6 50.1 1.0
CG A:LEU79 4.6 45.1 1.0
CE1 G:PHE105 4.7 49.7 1.0
O G:ALA101 4.7 42.1 1.0
CG A:GLU82 4.8 57.4 1.0
O A:ILE75 4.8 45.2 1.0
CG1 A:ILE75 4.9 38.4 1.0
CA A:ARG78 4.9 57.8 1.0
C G:LEU104 5.0 47.4 1.0

Chlorine binding site 2 out of 7 in 7uvn

Go back to Chlorine Binding Sites List in 7uvn
Chlorine binding site 2 out of 7 in the Crystal Structure of Human Clpp Protease in Complex with Tr-57


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Clpp Protease in Complex with Tr-57 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl301

b:72.0
occ:1.00
 CL01 B:P3O301 0.0 72.0 1.0
C02 B:P3O301 1.8 55.5 1.0
C03 B:P3O301 2.8 54.9 1.0
C30 B:P3O301 2.8 52.9 1.0
CG B:ARG78 3.3 48.2 1.0
CD2 B:LEU79 3.4 43.9 1.0
CD1 A:PHE105 3.7 45.3 1.0
CB A:PHE105 3.7 45.7 1.0
CA A:PHE105 4.0 47.5 1.0
C04 B:P3O301 4.0 52.3 1.0
C29 B:P3O301 4.1 56.6 1.0
NH1 B:ARG78 4.1 58.9 1.0
CG A:PHE105 4.1 47.6 1.0
CB B:ARG78 4.2 49.9 1.0
O B:ARG78 4.3 52.5 1.0
C B:ARG78 4.3 52.3 1.0
N B:LEU79 4.4 50.9 1.0
CZ B:ARG78 4.4 65.2 1.0
CD B:ARG78 4.5 57.1 1.0
C05 B:P3O301 4.6 51.4 1.0
N A:PHE105 4.6 49.2 1.0
NE B:ARG78 4.6 63.4 1.0
CG B:LEU79 4.7 46.8 1.0
CA B:LEU79 4.7 49.5 1.0
CE1 A:PHE105 4.7 51.4 1.0
CG B:GLU82 4.8 47.0 1.0
O A:ALA101 4.8 41.7 1.0
O B:ILE75 4.8 49.0 1.0
CA B:ARG78 4.9 54.0 1.0
CG1 B:ILE75 5.0 31.9 1.0
OG A:SER108 5.0 50.6 1.0

Chlorine binding site 3 out of 7 in 7uvn

Go back to Chlorine Binding Sites List in 7uvn
Chlorine binding site 3 out of 7 in the Crystal Structure of Human Clpp Protease in Complex with Tr-57


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human Clpp Protease in Complex with Tr-57 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl301

b:70.5
occ:1.00
 CL01 C:P3O301 0.0 70.5 1.0
C02 C:P3O301 1.8 54.2 1.0
C03 C:P3O301 2.8 51.7 1.0
C30 C:P3O301 2.8 46.1 1.0
CG C:ARG78 3.4 52.1 1.0
CD2 C:LEU79 3.5 46.8 1.0
CD1 B:PHE105 3.7 44.5 1.0
CB B:PHE105 3.8 42.3 1.0
C04 C:P3O301 4.0 49.0 1.0
CA B:PHE105 4.1 38.5 1.0
C29 C:P3O301 4.1 45.5 1.0
O C:ARG78 4.2 56.5 1.0
CG B:PHE105 4.2 46.4 1.0
CZ C:ARG78 4.2 59.0 1.0
C C:ARG78 4.2 55.0 1.0
NH1 C:ARG78 4.3 63.1 1.0
N C:LEU79 4.3 54.0 1.0
CB C:ARG78 4.3 54.2 1.0
NE C:ARG78 4.3 52.7 1.0
CA C:LEU79 4.4 52.3 1.0
CD C:ARG78 4.4 51.8 1.0
C05 C:P3O301 4.6 44.6 1.0
CD1 C:ILE75 4.6 36.9 1.0
CG C:LEU79 4.6 50.4 1.0
N B:PHE105 4.6 37.5 1.0
NH2 C:ARG78 4.8 60.4 1.0
O B:ALA101 4.8 41.2 1.0
CE1 B:PHE105 4.8 46.7 1.0
O C:ILE75 4.8 51.1 1.0
CA C:ARG78 4.9 56.5 1.0

Chlorine binding site 4 out of 7 in 7uvn

Go back to Chlorine Binding Sites List in 7uvn
Chlorine binding site 4 out of 7 in the Crystal Structure of Human Clpp Protease in Complex with Tr-57


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human Clpp Protease in Complex with Tr-57 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl301

b:69.7
occ:1.00
 CL01 D:P3O301 0.0 69.7 1.0
C02 D:P3O301 1.8 59.4 1.0
C03 D:P3O301 2.8 57.6 1.0
C30 D:P3O301 2.8 58.4 1.0
CB C:PHE105 3.5 50.1 1.0
CD2 D:LEU79 3.6 44.8 1.0
CG D:ARG78 3.7 54.4 1.0
CA C:PHE105 3.7 51.9 1.0
CD1 C:PHE105 3.8 49.5 1.0
C04 D:P3O301 4.0 53.3 1.0
C29 D:P3O301 4.1 56.3 1.0
CG C:PHE105 4.1 47.9 1.0
N C:PHE105 4.2 49.7 1.0
O D:ARG78 4.4 53.8 1.0
CB D:ARG78 4.5 48.6 1.0
C D:ARG78 4.6 54.7 1.0
C05 D:P3O301 4.6 52.1 1.0
CG D:LEU79 4.6 51.9 1.0
O C:ALA101 4.6 43.6 1.0
N D:LEU79 4.7 53.6 1.0
CD D:ARG78 4.8 57.7 1.0
CA D:LEU79 4.8 48.4 1.0
NE D:ARG78 4.8 61.1 1.0
CG D:GLU82 4.8 50.8 1.0
CG1 D:ILE75 4.9 37.9 1.0
CE1 C:PHE105 4.9 49.8 1.0
O D:ILE75 5.0 51.5 1.0
C C:LEU104 5.0 51.5 1.0

Chlorine binding site 5 out of 7 in 7uvn

Go back to Chlorine Binding Sites List in 7uvn
Chlorine binding site 5 out of 7 in the Crystal Structure of Human Clpp Protease in Complex with Tr-57


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Human Clpp Protease in Complex with Tr-57 within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl301

b:71.1
occ:1.00
 CL01 E:P3O301 0.0 71.1 1.0
C02 E:P3O301 1.8 54.7 1.0
C03 E:P3O301 2.8 51.9 1.0
C30 E:P3O301 2.8 50.2 1.0
CD2 E:LEU79 3.5 44.0 1.0
CB D:PHE105 3.5 44.2 1.0
CG E:ARG78 3.5 54.2 1.0
CA D:PHE105 3.8 50.9 1.0
CD1 D:PHE105 3.9 48.2 1.0
C04 E:P3O301 4.0 49.7 1.0
C29 E:P3O301 4.1 53.3 1.0
CG D:PHE105 4.1 50.6 1.0
NH1 E:ARG78 4.3 60.8 1.0
CB E:ARG78 4.4 55.9 1.0
N D:PHE105 4.4 51.2 1.0
CG E:LEU79 4.4 51.0 1.0
CZ E:ARG78 4.4 56.8 1.0
N E:LEU79 4.4 55.1 1.0
C E:ARG78 4.4 54.5 1.0
O E:ARG78 4.4 56.4 1.0
NE E:ARG78 4.5 51.2 1.0
CD E:ARG78 4.5 48.7 1.0
CA E:LEU79 4.5 53.7 1.0
C05 E:P3O301 4.6 49.3 1.0
O D:ALA101 4.6 47.8 1.0
OG D:SER108 4.8 50.7 1.0
O E:ILE75 4.8 50.2 1.0
CD1 E:ILE75 4.9 46.8 1.0

Chlorine binding site 6 out of 7 in 7uvn

Go back to Chlorine Binding Sites List in 7uvn
Chlorine binding site 6 out of 7 in the Crystal Structure of Human Clpp Protease in Complex with Tr-57


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of Human Clpp Protease in Complex with Tr-57 within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl301

b:73.4
occ:1.00
 CL01 F:P3O301 0.0 73.4 1.0
C02 F:P3O301 1.8 66.9 1.0
C03 F:P3O301 2.8 61.9 1.0
C30 F:P3O301 2.8 65.0 1.0
CB E:PHE105 3.4 50.4 1.0
CG F:ARG78 3.5 63.4 1.0
CD2 F:LEU79 3.6 62.5 1.0
CA E:PHE105 3.8 50.0 1.0
CD1 E:PHE105 3.9 54.6 1.0
C04 F:P3O301 4.0 59.8 1.0
C29 F:P3O301 4.1 61.7 1.0
CG E:PHE105 4.1 53.1 1.0
O F:ARG78 4.2 58.3 1.0
C F:ARG78 4.3 60.8 1.0
N E:PHE105 4.3 52.9 1.0
CB F:ARG78 4.3 61.6 1.0
N F:LEU79 4.3 58.8 1.0
CA F:LEU79 4.4 53.4 1.0
CG F:LEU79 4.5 65.7 1.0
O E:ALA101 4.5 48.7 1.0
C05 F:P3O301 4.6 63.6 1.0
CD F:ARG78 4.6 67.9 1.0
NE F:ARG78 4.6 73.5 1.0
CD1 F:ILE75 4.7 54.0 1.0
CZ F:ARG78 4.8 76.9 1.0
O F:ILE75 4.8 59.8 1.0
CG F:GLU82 4.8 59.3 1.0
NH1 F:ARG78 4.9 76.9 1.0
CA F:ARG78 5.0 62.2 1.0
C E:LEU104 5.0 56.3 1.0

Chlorine binding site 7 out of 7 in 7uvn

Go back to Chlorine Binding Sites List in 7uvn
Chlorine binding site 7 out of 7 in the Crystal Structure of Human Clpp Protease in Complex with Tr-57


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Crystal Structure of Human Clpp Protease in Complex with Tr-57 within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Cl301

b:69.5
occ:1.00
 CL01 G:P3O301 0.0 69.5 1.0
C02 G:P3O301 1.8 59.0 1.0
C03 G:P3O301 2.8 53.2 1.0
C30 G:P3O301 2.8 56.7 1.0
CD2 G:LEU79 3.5 44.9 1.0
CG G:ARG78 3.6 48.7 1.0
CB F:PHE105 3.6 51.7 1.0
CA F:PHE105 3.9 45.8 1.0
CD1 F:PHE105 4.0 53.2 1.0
C04 G:P3O301 4.0 52.2 1.0
C29 G:P3O301 4.1 55.8 1.0
CG F:PHE105 4.3 52.8 1.0
N G:LEU79 4.4 46.0 1.0
N F:PHE105 4.4 43.9 1.0
CG G:LEU79 4.4 45.8 1.0
CB G:ARG78 4.4 44.4 1.0
C G:ARG78 4.4 45.4 1.0
O G:ARG78 4.4 45.0 1.0
CA G:LEU79 4.5 45.0 1.0
C05 G:P3O301 4.6 47.2 1.0
O F:ALA101 4.6 46.7 1.0
NH1 G:ARG78 4.7 54.2 1.0
CZ G:ARG78 4.8 65.6 1.0
CD G:ARG78 4.8 60.9 1.0
O G:ILE75 4.8 47.1 1.0
NE G:ARG78 4.8 64.8 1.0
CG1 G:ILE75 4.9 42.7 1.0

Reference:

M.F.Mabanglo, K.S.Wong, M.M.Barghash, E.Leung, S.H.W.Chuang, A.Ardalan, E.M.Majaesic, C.J.Wong, S.Zhang, H.Lang, D.S.Karanewsky, A.A.Iwanowicz, L.M.Graves, E.J.Iwanowicz, A.C.Gingras, W.A.Houry. Potent Clpp Agonists with Anticancer Properties Bind with Improved Structural Complementarity and Alter the Mitochondrial N-Terminome. Structure 2022.
ISSN: ISSN 0969-2126
PubMed: 36586405
DOI: 10.1016/J.STR.2022.12.002
Page generated: Tue Jul 30 05:11:37 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy