Chlorine in PDB 7wai: Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers)

All present enzymatic activity of Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers):
6.1.1.17;

The structure of Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers), PDB code: 7wai was solved by V.Sharma, Y.Manickam, K.Harlos, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.37 / 2.11
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	157.46, 47.363, 94.449, 90, 109.1, 90
R / Rfree (%)	19.4 / 24.1

The binding sites of Chlorine atom in the Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) (pdb code 7wai). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers), PDB code: 7wai:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1001 b:78.4 occ:1.00 O A:HOH1127 3.4 54.2 1.0 O A:HOH1165 3.6 61.9 1.0 NH2 A:ARG577 3.6 51.0 1.0 NH1 A:ARG577 3.8 49.8 1.0 CZ A:ARG577 4.2 58.8 1.0 OD2 A:ASP562 4.3 104.7 1.0 OG A:SER563 4.6 69.8 1.0 CB A:ASP562 4.7 91.1 1.0 NZ A:LYS766 4.7 61.8 1.0 CG A:ASP562 4.9 103.1 1.0

Chlorine binding site 2 out of 5 in the Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1002 b:70.4 occ:1.00 OG A:SER538 3.2 80.5 1.0 N A:SER538 3.5 69.3 1.0 OH A:TYR535 3.7 122.2 1.0 CA A:PHE537 3.9 64.6 1.0 CB A:PHE537 4.1 56.9 1.0 CB A:SER538 4.2 77.9 1.0 CB A:PRO594 4.2 64.1 1.0 C A:PHE537 4.2 66.4 1.0 CA A:PRO594 4.3 65.5 1.0 CA A:SER538 4.5 72.2 1.0 NZ A:LYS329 4.5 64.5 1.0 CZ A:TYR535 4.8 107.7 1.0 N A:PRO594 4.9 72.8 1.0

Chlorine binding site 3 out of 5 in the Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1003 b:88.0 occ:1.00 N A:SER548 3.1 79.7 1.0 CB A:SER548 3.2 87.0 1.0 NZ A:LYS551 3.6 103.3 1.0 N A:MET547 3.7 72.2 1.0 CA A:SER548 3.7 82.5 1.0 CE A:LYS551 3.8 103.7 1.0 C A:MET547 4.1 69.3 1.0 CD A:LYS551 4.3 97.2 1.0 CG1 A:VAL546 4.3 70.5 1.0 CA A:MET547 4.3 71.5 1.0 CA A:VAL546 4.4 71.4 1.0 OG A:SER548 4.5 94.0 1.0 C A:VAL546 4.5 76.8 1.0 CB A:MET547 4.7 77.6 1.0 CD2 A:PHE749 4.8 100.5 1.0 CB A:VAL546 4.9 69.2 1.0

Chlorine binding site 4 out of 5 in the Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1004 b:93.7 occ:1.00 NH2 A:ARG790 3.6 73.2 1.0 NE A:ARG790 3.9 65.0 1.0 CZ A:ARG790 4.2 72.2 1.0

Chlorine binding site 5 out of 5 in the Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1005 b:96.0 occ:1.00 O A:HOH1175 3.1 74.0 1.0 NH2 A:ARG471 3.4 69.6 1.0 NH2 A:ARG413 3.5 128.4 1.0 NH1 A:ARG416 3.7 87.5 1.0 NE A:ARG413 3.9 123.2 1.0 CZ A:ARG413 4.2 128.2 1.0 CG2 A:VAL468 4.3 51.4 1.0 NH2 A:ARG416 4.4 87.2 1.0 CZ A:ARG471 4.5 68.7 1.0 CZ A:ARG416 4.5 90.9 1.0 NH1 A:ARG471 4.7 64.2 1.0

V.K.Sharma, J.Chhibber-Goel, M.Yogavel, A.Sharma. Structural Characterization of Glutamyl-Trna Synthetase (Glurs) From Plasmodium Falciparum. Mol.Biochem.Parasitol. V. 253 11530 2022.
ISSN: ISSN 0166-6851
PubMed: 36370911
DOI: 10.1016/J.MOLBIOPARA.2022.111530