Chlorine in PDB 8au5: C-Met F1200I Mutant in Complex with Tepotinib

All present enzymatic activity of C-Met F1200I Mutant in Complex with Tepotinib:
2.7.10.1;

The structure of C-Met F1200I Mutant in Complex with Tepotinib, PDB code: 8au5 was solved by U.Graedler, A.Lammens, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	88.76 / 2.72
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	38.484, 43.173, 88.794, 90, 91.67, 90
R / Rfree (%)	23.4 / 27.8

The binding sites of Chlorine atom in the C-Met F1200I Mutant in Complex with Tepotinib (pdb code 8au5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the C-Met F1200I Mutant in Complex with Tepotinib, PDB code: 8au5:

Chlorine binding site 1 out of 1 in the C-Met F1200I Mutant in Complex with Tepotinib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of C-Met F1200I Mutant in Complex with Tepotinib within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1404 b:92.2 occ:1.00 CG A:GLN1187 4.2 58.3 1.0 O A:GLY1183 4.2 54.2 1.0 CZ A:PHE1341 4.3 52.4 1.0 CD2 A:LEU1186 4.3 49.5 1.0 NE2 A:GLN1187 4.5 56.5 1.0 CE2 A:PHE1341 4.5 49.2 1.0 CA A:GLY1183 4.6 52.0 1.0 CD A:GLN1187 4.6 62.1 1.0 CE1 A:PHE1341 4.7 48.3 1.0 C A:GLY1183 4.7 51.5 1.0 CG A:LEU1186 4.8 50.0 1.0 NZ A:LYS1190 4.8 53.0 1.0

U.Graedler, A.Lammens. Biophysical and Structural Characterization of the Impact of C-Met Phosphorylation on Tepotinib Binding To Be Published.