Chlorine in PDB 8aym: Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118

The structure of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 also contains other interesting chemical elements:

Fluorine

(F)

18 atoms

The binding sites of Chlorine atom in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 (pdb code 8aym). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118, PDB code: 8aym:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 within 5.0Å range: probe atom residue distance (Å) B Occ I:Cl501 b:12.3 occ:1.00 CL1 I:XVD501 0.0 12.3 1.0 C1 I:XVD501 1.8 12.3 1.0 C2 I:XVD501 2.7 12.3 1.0 C6 I:XVD501 2.8 12.3 1.0 C7 I:XVD501 3.1 12.3 1.0 CZ C:PHE527 3.5 9.8 1.0 CA I:GLY209 3.7 12.8 1.0 C12 I:XVD501 3.7 12.3 1.0 C8 I:XVD501 3.8 12.3 1.0 C3 I:XVD501 4.0 12.3 1.0 C5 I:XVD501 4.0 12.3 1.0 CE2 C:PHE527 4.2 9.8 1.0 CD2 I:TYR206 4.3 13.6 1.0 CE1 C:PHE527 4.4 9.8 1.0 CA I:TYR206 4.4 13.6 1.0 C I:GLY209 4.5 12.8 1.0 C4 I:XVD501 4.5 12.3 1.0 N I:GLY209 4.6 12.8 1.0 O I:TYR206 4.7 13.6 1.0 C9 I:XVD501 4.7 12.3 1.0 C11 I:XVD501 4.7 12.3 1.0 CB I:TYR206 4.8 13.6 1.0 C7 C:PLM906 4.9 11.6 1.0 O I:GLY209 5.0 12.8 1.0 CG I:TYR206 5.0 13.6 1.0

Chlorine binding site 2 out of 2 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 within 5.0Å range: probe atom residue distance (Å) B Occ J:Cl1702 b:12.3 occ:1.00 CL1 J:XVD1702 0.0 12.3 1.0 C1 J:XVD1702 1.8 12.3 1.0 C2 J:XVD1702 2.7 12.3 1.0 C6 J:XVD1702 2.8 12.3 1.0 C7 J:XVD1702 3.1 12.3 1.0 CZ A:PHE527 3.5 9.8 1.0 CA J:GLY209 3.7 12.9 1.0 C12 J:XVD1702 3.7 12.3 1.0 C8 J:XVD1702 3.8 12.3 1.0 C3 J:XVD1702 4.0 12.3 1.0 C5 J:XVD1702 4.0 12.3 1.0 CE2 A:PHE527 4.2 9.8 1.0 CD2 J:TYR206 4.3 13.6 1.0 CE1 A:PHE527 4.4 9.8 1.0 CA J:TYR206 4.4 13.6 1.0 C J:GLY209 4.5 12.9 1.0 C4 J:XVD1702 4.6 12.3 1.0 N J:GLY209 4.6 12.9 1.0 O J:TYR206 4.7 13.6 1.0 C9 J:XVD1702 4.7 12.3 1.0 C11 J:XVD1702 4.7 12.3 1.0 CB J:TYR206 4.8 13.6 1.0 C7 A:PLM906 4.9 11.6 1.0 O J:GLY209 5.0 12.9 1.0 CG J:TYR206 5.0 13.6 1.0

D.Zhang, R.Lape, S.A.Shaikh, B.K.Kohegyi, J.F.Watson, O.Cais, T.Nakagawa, I.H.Greger. Modulatory Mechanisms of Tarp Gamma 8-Selective Ampa Receptor Therapeutics. Nat Commun V. 14 1659 2023.
ISSN: ESSN 2041-1723
PubMed: 36966141
DOI: 10.1038/S41467-023-37259-5