Chlorine in PDB 8bhk: Gaba-A Receptor A5 Homomer - A5V3 - Diazepam

The binding sites of Chlorine atom in the Gaba-A Receptor A5 Homomer - A5V3 - Diazepam (pdb code 8bhk). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Gaba-A Receptor A5 Homomer - A5V3 - Diazepam, PDB code: 8bhk:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the Gaba-A Receptor A5 Homomer - A5V3 - Diazepam


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Gaba-A Receptor A5 Homomer - A5V3 - Diazepam within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl502 b:57.4 occ:1.00 CL A:DZP502 0.0 57.4 1.0 C9 A:DZP502 1.7 46.4 1.0 C14 A:DZP502 2.7 41.9 1.0 C8 A:DZP502 2.7 48.5 1.0 H8 A:DZP502 2.8 48.2 1.0 H14 A:DZP502 2.8 46.5 1.0 HB3 A:HIS105 2.8 32.9 1.0 HD1 A:HIS105 2.9 35.5 1.0 HD22 E:ASN51 3.5 43.2 1.0 HZ E:PHE68 3.5 34.6 1.0 ND1 A:HIS105 3.7 37.8 1.0 HE1 E:PHE68 3.7 34.5 1.0 CB A:HIS105 3.7 28.9 1.0 ND2 E:ASN51 3.7 46.1 1.0 OD1 E:ASN51 3.9 47.4 1.0 CG E:ASN51 4.0 45.5 1.0 C7 A:DZP502 4.0 48.5 1.0 C13 A:DZP502 4.0 45.0 1.0 HA A:HIS105 4.0 33.8 1.0 CZ E:PHE68 4.1 34.3 1.0 HD21 E:ASN51 4.2 42.5 1.0 CE1 E:PHE68 4.2 34.3 1.0 CG A:HIS105 4.2 32.4 1.0 O A:HIS105 4.2 38.1 1.0 CA A:HIS105 4.3 31.8 1.0 HB2 A:HIS105 4.4 33.9 1.0 C6 A:DZP502 4.5 46.4 1.0 C A:HIS105 4.6 31.4 1.0 HB2 E:ASN51 4.6 42.1 1.0 H7 A:DZP502 4.8 48.4 1.0 CE1 A:HIS105 4.9 35.8 1.0 CB E:ASN51 4.9 39.5 1.0 H4 A:DZP502 5.0 47.5 1.0 HE2 A:PHE103 5.0 29.3 1.0

Chlorine binding site 2 out of 5 in the Gaba-A Receptor A5 Homomer - A5V3 - Diazepam


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Gaba-A Receptor A5 Homomer - A5V3 - Diazepam within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl502 b:57.4 occ:1.00 CL B:DZP502 0.0 57.4 1.0 C9 B:DZP502 1.7 46.4 1.0 C14 B:DZP502 2.7 41.9 1.0 C8 B:DZP502 2.7 48.5 1.0 H8 B:DZP502 2.8 48.2 1.0 H14 B:DZP502 2.8 46.5 1.0 HB3 B:HIS105 2.8 32.9 1.0 HD1 B:HIS105 2.9 35.5 1.0 HZ A:PHE68 3.5 34.6 1.0 HD22 A:ASN51 3.5 43.2 1.0 ND1 B:HIS105 3.7 37.8 1.0 HE1 A:PHE68 3.7 34.5 1.0 CB B:HIS105 3.7 28.9 1.0 ND2 A:ASN51 3.7 46.1 1.0 OD1 A:ASN51 3.9 47.4 1.0 CG A:ASN51 4.0 45.5 1.0 C7 B:DZP502 4.0 48.5 1.0 C13 B:DZP502 4.0 45.0 1.0 HA B:HIS105 4.0 33.8 1.0 CZ A:PHE68 4.1 34.3 1.0 HD21 A:ASN51 4.1 42.5 1.0 CE1 A:PHE68 4.2 34.3 1.0 CG B:HIS105 4.2 32.4 1.0 O B:HIS105 4.2 38.1 1.0 CA B:HIS105 4.3 31.8 1.0 HB2 B:HIS105 4.4 33.9 1.0 C6 B:DZP502 4.5 46.4 1.0 C B:HIS105 4.6 31.4 1.0 HB2 A:ASN51 4.6 42.1 1.0 H7 B:DZP502 4.8 48.4 1.0 CE1 B:HIS105 4.9 35.8 1.0 CB A:ASN51 4.9 39.5 1.0 H4 B:DZP502 5.0 47.5 1.0 HE2 B:PHE103 5.0 29.3 1.0

Chlorine binding site 3 out of 5 in the Gaba-A Receptor A5 Homomer - A5V3 - Diazepam


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Gaba-A Receptor A5 Homomer - A5V3 - Diazepam within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl502 b:57.4 occ:1.00 CL C:DZP502 0.0 57.4 1.0 C9 C:DZP502 1.7 46.4 1.0 C14 C:DZP502 2.7 41.9 1.0 C8 C:DZP502 2.7 48.5 1.0 H8 C:DZP502 2.8 48.2 1.0 H14 C:DZP502 2.8 46.5 1.0 HB3 C:HIS105 2.8 32.9 1.0 HD1 C:HIS105 2.9 35.5 1.0 HD22 B:ASN51 3.5 43.2 1.0 HZ B:PHE68 3.5 34.6 1.0 ND1 C:HIS105 3.7 37.8 1.0 HE1 B:PHE68 3.7 34.5 1.0 CB C:HIS105 3.7 28.9 1.0 ND2 B:ASN51 3.8 46.1 1.0 OD1 B:ASN51 4.0 47.4 1.0 CG B:ASN51 4.0 45.5 1.0 C7 C:DZP502 4.0 48.5 1.0 C13 C:DZP502 4.0 45.0 1.0 HA C:HIS105 4.0 33.8 1.0 CZ B:PHE68 4.1 34.3 1.0 HD21 B:ASN51 4.2 42.5 1.0 CG C:HIS105 4.2 32.4 1.0 CE1 B:PHE68 4.2 34.3 1.0 O C:HIS105 4.2 38.1 1.0 CA C:HIS105 4.3 31.8 1.0 HB2 C:HIS105 4.4 33.9 1.0 C6 C:DZP502 4.5 46.4 1.0 C C:HIS105 4.6 31.4 1.0 HB2 B:ASN51 4.6 42.1 1.0 H7 C:DZP502 4.8 48.4 1.0 CE1 C:HIS105 4.9 35.8 1.0 CB B:ASN51 4.9 39.5 1.0 H4 C:DZP502 5.0 47.5 1.0 HE2 C:PHE103 5.0 29.3 1.0

Chlorine binding site 4 out of 5 in the Gaba-A Receptor A5 Homomer - A5V3 - Diazepam


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Gaba-A Receptor A5 Homomer - A5V3 - Diazepam within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl502 b:57.4 occ:1.00 CL D:DZP502 0.0 57.4 1.0 C9 D:DZP502 1.7 46.4 1.0 C14 D:DZP502 2.7 41.9 1.0 C8 D:DZP502 2.7 48.5 1.0 H8 D:DZP502 2.8 48.2 1.0 H14 D:DZP502 2.8 46.5 1.0 HB3 D:HIS105 2.8 32.9 1.0 HD1 D:HIS105 2.9 35.5 1.0 HD22 C:ASN51 3.5 43.2 1.0 HZ C:PHE68 3.5 34.6 1.0 ND1 D:HIS105 3.7 37.8 1.0 HE1 C:PHE68 3.7 34.5 1.0 CB D:HIS105 3.7 28.9 1.0 ND2 C:ASN51 3.7 46.1 1.0 OD1 C:ASN51 4.0 47.4 1.0 CG C:ASN51 4.0 45.5 1.0 C7 D:DZP502 4.0 48.5 1.0 C13 D:DZP502 4.0 45.0 1.0 HA D:HIS105 4.0 33.8 1.0 CZ C:PHE68 4.1 34.3 1.0 HD21 C:ASN51 4.2 42.5 1.0 CE1 C:PHE68 4.2 34.3 1.0 CG D:HIS105 4.2 32.4 1.0 O D:HIS105 4.2 38.1 1.0 CA D:HIS105 4.3 31.8 1.0 HB2 D:HIS105 4.4 33.9 1.0 C6 D:DZP502 4.5 46.4 1.0 C D:HIS105 4.6 31.4 1.0 HB2 C:ASN51 4.6 42.1 1.0 H7 D:DZP502 4.8 48.4 1.0 CE1 D:HIS105 4.9 35.8 1.0 CB C:ASN51 4.9 39.5 1.0 H4 D:DZP502 5.0 47.5 1.0 HE2 D:PHE103 5.0 29.3 1.0

Chlorine binding site 5 out of 5 in the Gaba-A Receptor A5 Homomer - A5V3 - Diazepam


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Gaba-A Receptor A5 Homomer - A5V3 - Diazepam within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl502 b:57.4 occ:1.00 CL E:DZP502 0.0 57.4 1.0 C9 E:DZP502 1.7 46.4 1.0 C14 E:DZP502 2.7 41.9 1.0 C8 E:DZP502 2.7 48.5 1.0 H8 E:DZP502 2.8 48.2 1.0 H14 E:DZP502 2.8 46.5 1.0 HB3 E:HIS105 2.8 32.9 1.0 HD1 E:HIS105 2.9 35.5 1.0 HD22 D:ASN51 3.5 43.2 1.0 HZ D:PHE68 3.5 34.6 1.0 ND1 E:HIS105 3.7 37.8 1.0 HE1 D:PHE68 3.7 34.5 1.0 CB E:HIS105 3.7 28.9 1.0 ND2 D:ASN51 3.7 46.1 1.0 OD1 D:ASN51 3.9 47.4 1.0 CG D:ASN51 4.0 45.5 1.0 C7 E:DZP502 4.0 48.5 1.0 C13 E:DZP502 4.0 45.0 1.0 HA E:HIS105 4.0 33.8 1.0 CZ D:PHE68 4.1 34.3 1.0 HD21 D:ASN51 4.2 42.5 1.0 CE1 D:PHE68 4.2 34.3 1.0 CG E:HIS105 4.2 32.4 1.0 O E:HIS105 4.2 38.1 1.0 CA E:HIS105 4.3 31.8 1.0 HB2 E:HIS105 4.4 33.9 1.0 C6 E:DZP502 4.5 46.4 1.0 C E:HIS105 4.6 31.4 1.0 HB2 D:ASN51 4.6 42.1 1.0 H7 E:DZP502 4.8 48.4 1.0 CE1 E:HIS105 4.9 35.8 1.0 CB D:ASN51 4.9 39.5 1.0 H4 E:DZP502 5.0 47.5 1.0 HE2 E:PHE103 5.0 29.3 1.0

V.B.Kasaragod, T.M.Malinauskas, A.A.Wahid, J.Lengyel, F.Knoflach, S.W.Hardwick, C.F.Jones, W.N.Chen, X.Lucas, K.E.Omari, D.Y.Chirgadze, A.R.Aricescu, G.Cecere, M.C.Hernandez, P.S.Miller. The Molecular Basis of Drug Selectivity For ALPHA5 Subunit-Containing Gabaa Receptors Nat.Struct.Mol.Biol. 2023.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-023-01133-1