Chlorine in PDB 8bzn: Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I

The structure of Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I, PDB code: 8bzn was solved by H.Wang, S.R.A.Rizvi, D.Dong, J.Lou, Q.Wang, W.Sopipong, F.Najar, P.K.Agarwal, F.Kozielski, S.Haider, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	52.43 / 2.19
Space group	I 21 3
Cell size a, b, c (Å), α, β, γ (°)	104.867, 104.867, 104.867, 90, 90, 90
R / Rfree (%)	18 / 23.5

The structure of Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I (pdb code 8bzn). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I, PDB code: 8bzn:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl203 b:55.2 occ:1.00 O A:HOH361 3.0 52.3 1.0 N A:GLY127 3.0 60.0 1.0 O A:HOH312 3.1 47.4 1.0 NE2 A:GLN65 3.2 35.3 1.0 CA A:GLY127 3.4 59.7 1.0 CB A:TYR126 3.6 46.7 1.0 CG A:PRO100 3.7 42.9 1.0 CD1 A:TRP123 3.8 44.1 1.0 CB A:TRP123 3.9 49.9 1.0 C A:TYR126 4.1 59.5 1.0 CG A:TRP123 4.3 41.1 1.0 CD A:GLN65 4.3 43.2 1.0 CD A:PRO100 4.3 34.1 1.0 N A:TRP123 4.4 52.7 1.0 CG A:GLN65 4.4 42.1 1.0 CA A:TYR126 4.5 58.2 1.0 CA A:TRP123 4.7 51.9 1.0 CB A:PRO100 4.7 47.0 1.0 C A:GLY127 4.7 62.6 1.0 O A:TRP123 4.8 56.1 1.0 CG A:TYR126 4.8 49.8 1.0 O A:HOH369 4.8 50.9 1.0 O A:GLY52 4.8 44.2 1.0 CE A:MET122 4.9 49.3 1.0 N A:PRO100 4.9 38.6 1.0 NE1 A:TRP123 5.0 38.2 1.0

Chlorine binding site 2 out of 3 in the Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl204 b:42.8 occ:1.00 O A:HOH370 4.4 47.0 1.0 O A:HOH346 4.6 45.1 1.0

Chlorine binding site 3 out of 3 in the Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl205 b:55.1 occ:1.00 OG1 A:THR12 3.2 37.2 1.0 CA A:GLY9 3.3 44.8 1.0 N A:THR12 3.5 28.1 1.0 C A:GLY9 3.6 37.4 1.0 O A:MET8 3.6 53.2 1.0 N A:SER11 3.7 27.6 1.0 CB A:SER11 3.8 27.8 1.0 O A:GLY9 3.9 39.8 1.0 CB A:THR12 4.0 39.6 1.0 CA A:SER11 4.1 33.5 1.0 N A:ASN10 4.1 33.5 1.0 C A:SER11 4.2 34.7 1.0 CA A:THR12 4.3 33.3 1.0 N A:GLY9 4.4 48.2 1.0 C A:MET8 4.4 63.3 1.0 C A:ASN10 4.7 29.5 1.0 OG A:SER11 4.8 40.5 1.0 O A:HOH357 5.0 36.0 1.0

H.Wang, S.R.A.Rizvi, D.Dong, J.Lou, Q.Wang, W.Sopipong, F.Najar, P.K.Agarwal, F.Kozielski, S.Haider. Emerging Variants of Sars-Cov-2 NSP10 Highlight Strong Functional Conservation of Its Binding to Two Non-Structural Proteins, NSP14 and NSP16 To Be Published.