Chlorine in PDB 8f7l: Human Nampt in Complex with Substrate Nam and Small Molecule Activator Zn-29-S

Enzymatic activity of Human Nampt in Complex with Substrate Nam and Small Molecule Activator Zn-29-S

All present enzymatic activity of Human Nampt in Complex with Substrate Nam and Small Molecule Activator Zn-29-S:
2.4.2.12;

Protein crystallography data

The structure of Human Nampt in Complex with Substrate Nam and Small Molecule Activator Zn-29-S, PDB code: 8f7l was solved by K.Ratia, R.Xiong, Z.Shen, G.R.Thatcher, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	65.58 / 2.20
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	60.888, 106.997, 83.603, 90, 96.88, 90
*R / R_free (%)*	22.6 / 26.4

Other elements in 8f7l:

The structure of Human Nampt in Complex with Substrate Nam and Small Molecule Activator Zn-29-S also contains other interesting chemical elements:

Fluorine

(F)

2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human Nampt in Complex with Substrate Nam and Small Molecule Activator Zn-29-S (pdb code 8f7l). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Nampt in Complex with Substrate Nam and Small Molecule Activator Zn-29-S, PDB code: 8f7l:

Chlorine binding site 1 out of 1 in 8f7l

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Chlorine Binding Sites List in 8f7l

Chlorine binding site 1 out of 1 in the Human Nampt in Complex with Substrate Nam and Small Molecule Activator Zn-29-S

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Nampt in Complex with Substrate Nam and Small Molecule Activator Zn-29-S within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl1004 b:60.5 occ:1.00	N	A:LYS77	3.3	41.1	1.0
	CA	A:THR76	3.6	36.8	1.0
	CB	A:THR76	3.7	35.9	1.0
	CD1	A:LEU105	3.8	32.2	1.0
	C	A:THR76	3.9	41.3	1.0
	CD2	A:LEU105	4.0	40.6	1.0
	NZ	A:LYS73	4.1	45.2	1.0
	CE	A:LYS73	4.1	39.7	1.0
	CB	A:LYS77	4.2	46.6	1.0
	CG2	A:THR76	4.2	35.4	1.0
	CA	A:LYS77	4.3	43.5	1.0
	CG	A:LEU105	4.5	37.4	1.0
	OE1	A:GLU78	4.5	53.7	1.0
	O	A:VAL75	4.7	34.2	1.0
	N	A:THR76	4.9	34.5	1.0

Reference:

K.Ratia, R.Xiong, Z.Shen, G.R.Thatcher. Human Nampt in Complex with Substrate Nam and Small Molecule Activator Zn-29-S To Be Published.

Page generated: Tue Jul 30 09:22:46 2024

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