Chlorine in PDB 8fpk: Lbd Conformation 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)

The binding sites of Chlorine atom in the Lbd Conformation 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) (pdb code 8fpk). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Lbd Conformation 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg), PDB code: 8fpk:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Lbd Conformation 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Lbd Conformation 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl902 b:90.6 occ:1.00 CL B:CYZ902 0.0 90.6 1.0 C13 B:CYZ902 1.8 76.2 1.0 C12 B:CYZ902 2.7 76.0 1.0 C14 B:CYZ902 2.8 75.4 1.0 OD1 B:ASP760 2.9 64.4 1.0 O4 B:CYZ902 2.9 80.3 1.0 S2 B:CYZ902 3.1 93.2 1.0 C B:LEU759 3.3 49.1 1.0 N B:ASP760 3.4 54.3 1.0 CB B:LEU759 3.4 49.0 1.0 N3 B:CYZ902 3.4 78.8 1.0 O B:LEU759 3.4 49.0 1.0 CA B:ASP760 3.8 49.7 1.0 CG B:ASP760 4.0 62.1 1.0 CA B:LEU759 4.0 45.6 1.0 C11 B:CYZ902 4.0 75.4 1.0 C10 B:CYZ902 4.1 74.6 1.0 O B:PHE495 4.2 54.4 1.0 CB B:ASP760 4.5 53.6 1.0 C9 B:CYZ902 4.6 75.2 1.0 CG B:LEU759 4.7 50.1 1.0 O3 B:CYZ902 4.7 81.2 1.0 CD1 B:LEU759 4.8 47.3 1.0 OD2 B:ASP760 5.0 61.7 1.0

Chlorine binding site 2 out of 4 in the Lbd Conformation 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Lbd Conformation 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl902 b:77.3 occ:1.00 CL C:CYZ902 0.0 77.3 1.0 C13 C:CYZ902 1.8 59.0 1.0 C12 C:CYZ902 2.7 57.5 1.0 C14 C:CYZ902 2.8 51.9 1.0 O4 C:CYZ902 2.8 70.9 1.0 OD1 C:ASP760 2.9 57.8 1.0 S2 C:CYZ902 3.2 80.5 1.0 C C:LEU759 3.4 39.1 1.0 N C:ASP760 3.4 41.1 1.0 O C:LEU759 3.5 46.7 1.0 CB C:LEU759 3.5 40.1 1.0 N3 C:CYZ902 3.6 57.0 1.0 CA C:ASP760 3.7 34.1 1.0 CG C:ASP760 3.8 57.1 1.0 C11 C:CYZ902 4.0 52.9 1.0 C10 C:CYZ902 4.1 56.0 1.0 CA C:LEU759 4.1 32.0 1.0 O C:PHE495 4.2 41.2 1.0 CB C:ASP760 4.3 41.0 1.0 C9 C:CYZ902 4.6 56.3 1.0 OD2 C:ASP760 4.6 59.3 1.0 O3 C:CYZ902 4.7 54.3 1.0 CG C:LEU759 4.8 35.5 1.0 CB C:LYS763 4.9 33.5 1.0 CD1 C:LEU759 4.9 32.4 1.0 C C:ASP760 5.0 38.9 1.0

Chlorine binding site 3 out of 4 in the Lbd Conformation 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Lbd Conformation 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl902 b:75.9 occ:1.00 CL A:CYZ902 0.0 75.9 1.0 C13 A:CYZ902 1.8 58.7 1.0 C12 A:CYZ902 2.7 57.2 1.0 C14 A:CYZ902 2.8 49.4 1.0 O4 A:CYZ902 2.9 68.7 1.0 OD1 A:ASP760 3.0 62.6 1.0 S2 A:CYZ902 3.2 81.0 1.0 N A:ASP760 3.3 43.1 1.0 C A:LEU759 3.4 39.7 1.0 CB A:LEU759 3.5 38.9 1.0 N3 A:CYZ902 3.6 53.9 1.0 CG A:ASP760 3.6 61.3 1.0 CA A:ASP760 3.6 35.8 1.0 O A:LEU759 3.6 46.4 1.0 C11 A:CYZ902 4.0 50.9 1.0 C10 A:CYZ902 4.1 53.5 1.0 CA A:LEU759 4.1 33.0 1.0 CB A:ASP760 4.1 44.8 1.0 OD2 A:ASP760 4.3 61.4 1.0 O A:PHE495 4.3 42.0 1.0 C9 A:CYZ902 4.6 55.4 1.0 O3 A:CYZ902 4.7 53.6 1.0 CG A:LEU759 4.9 38.2 1.0 C A:ASP760 4.9 42.1 1.0 CD1 A:LEU759 4.9 35.1 1.0

Chlorine binding site 4 out of 4 in the Lbd Conformation 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Lbd Conformation 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl902 b:94.2 occ:1.00 CL D:CYZ902 0.0 94.2 1.0 C13 D:CYZ902 1.8 74.3 1.0 O3 D:CYZ902 2.7 74.0 1.0 C12 D:CYZ902 2.7 74.4 1.0 C14 D:CYZ902 2.8 71.8 1.0 OD1 D:ASP760 2.8 65.8 1.0 S2 D:CYZ902 3.1 90.2 1.0 N D:ASP760 3.3 60.1 1.0 C D:LEU759 3.3 48.0 1.0 CB D:LEU759 3.4 45.3 1.0 O D:LEU759 3.5 45.6 1.0 N3 D:CYZ902 3.7 77.3 1.0 CA D:ASP760 3.7 54.7 1.0 CG D:ASP760 3.9 64.1 1.0 CA D:LEU759 4.0 43.2 1.0 C11 D:CYZ902 4.0 73.4 1.0 C10 D:CYZ902 4.1 72.3 1.0 CB D:ASP760 4.4 58.9 1.0 C9 D:CYZ902 4.6 74.4 1.0 O D:PHE495 4.6 38.8 1.0 O4 D:CYZ902 4.6 77.5 1.0 CG D:LEU759 4.7 48.4 1.0 CD1 D:LEU759 4.8 41.7 1.0 N D:LEU759 4.9 49.6 1.0

T.Nakagawa, X.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3