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Chlorine in PDB 8fq8: Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110)

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110) (pdb code 8fq8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110), PDB code: 8fq8:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 8fq8

Go back to Chlorine Binding Sites List in 8fq8
Chlorine binding site 1 out of 4 in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1302

b:73.3
occ:1.00
CL A:CYZ1302 0.0 73.3 1.0
C13 A:CYZ1302 1.8 44.3 1.0
C12 A:CYZ1302 2.8 39.5 1.0
C14 A:CYZ1302 2.8 41.3 1.0
O4 A:CYZ1302 3.1 62.2 1.0
N A:ASP760 3.2 33.9 1.0
S2 A:CYZ1302 3.2 61.6 1.0
N3 A:CYZ1302 3.4 49.8 1.0
CA A:ASP760 3.5 32.7 1.0
CB A:LEU759 3.6 32.6 1.0
CB A:ASP760 3.6 40.6 1.0
C A:LEU759 3.7 41.9 1.0
C11 A:CYZ1302 4.0 38.8 1.0
O A:HOH1401 4.0 0.0 1.0
C10 A:CYZ1302 4.1 36.6 1.0
CA A:LEU759 4.2 18.6 1.0
O A:LEU759 4.3 57.7 1.0
C9 A:CYZ1302 4.6 35.0 1.0
CG A:LEU759 4.8 37.2 1.0
O3 A:CYZ1302 4.8 36.1 1.0
CD1 A:LEU759 4.8 23.4 1.0
O A:PHE495 4.9 21.9 1.0
CG A:ASP760 4.9 49.8 1.0
N A:LEU759 4.9 30.5 1.0
CB D:SER729 5.0 47.1 1.0

Chlorine binding site 2 out of 4 in 8fq8

Go back to Chlorine Binding Sites List in 8fq8
Chlorine binding site 2 out of 4 in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1302

b:88.3
occ:1.00
CL B:CYZ1302 0.0 88.3 1.0
C13 B:CYZ1302 1.8 60.8 1.0
C12 B:CYZ1302 2.7 59.1 1.0
C14 B:CYZ1302 2.8 60.3 1.0
O4 B:CYZ1302 3.1 63.7 1.0
OD1 B:ASP760 3.2 72.7 1.0
S2 B:CYZ1302 3.2 70.5 1.0
CG B:ASP760 3.3 77.5 1.0
O B:HOH1402 3.3 50.2 1.0
N3 B:CYZ1302 3.4 62.9 1.0
N B:ASP760 3.5 68.6 1.0
OD2 B:ASP760 3.5 74.8 1.0
CA B:ASP760 3.6 69.6 1.0
C B:LEU759 3.7 64.6 1.0
CB B:LEU759 3.8 65.1 1.0
OG C:SER729 3.9 55.6 1.0
O B:LEU759 4.0 66.3 1.0
C11 B:CYZ1302 4.0 67.7 1.0
CB B:ASP760 4.1 73.6 1.0
C10 B:CYZ1302 4.1 63.0 1.0
CA B:LEU759 4.4 63.1 1.0
C9 B:CYZ1302 4.6 68.2 1.0
O3 B:CYZ1302 4.8 69.1 1.0
O B:PHE495 4.8 59.8 1.0
CD1 B:LEU759 5.0 57.1 1.0
CG B:LEU759 5.0 59.3 1.0

Chlorine binding site 3 out of 4 in 8fq8

Go back to Chlorine Binding Sites List in 8fq8
Chlorine binding site 3 out of 4 in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1302

b:79.2
occ:1.00
CL C:CYZ1302 0.0 79.2 1.0
C13 C:CYZ1302 1.8 46.0 1.0
C12 C:CYZ1302 2.7 41.4 1.0
C14 C:CYZ1302 2.8 43.8 1.0
O4 C:CYZ1302 3.0 59.6 1.0
S2 C:CYZ1302 3.2 62.0 1.0
N C:ASP760 3.3 34.4 1.0
N3 C:CYZ1302 3.4 45.7 1.0
CA C:ASP760 3.5 30.7 1.0
CB C:LEU759 3.6 31.1 1.0
CB C:ASP760 3.7 37.2 1.0
C C:LEU759 3.7 38.6 1.0
O C:HOH1401 4.0 6.1 1.0
C11 C:CYZ1302 4.0 38.8 1.0
C10 C:CYZ1302 4.1 40.9 1.0
O C:LEU759 4.3 54.8 1.0
CA C:LEU759 4.3 18.3 1.0
C9 C:CYZ1302 4.6 36.5 1.0
O3 C:CYZ1302 4.8 44.0 1.0
CG C:LEU759 4.8 34.9 1.0
CD1 C:LEU759 4.9 23.5 1.0
CB B:SER729 4.9 44.1 1.0
OG C:SER754 4.9 30.4 1.0
O C:PHE495 5.0 23.9 1.0
CG C:ASP760 5.0 45.6 1.0

Chlorine binding site 4 out of 4 in 8fq8

Go back to Chlorine Binding Sites List in 8fq8
Chlorine binding site 4 out of 4 in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110) within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1302

b:89.0
occ:1.00
CL D:CYZ1302 0.0 89.0 1.0
C13 D:CYZ1302 1.8 61.5 1.0
C12 D:CYZ1302 2.7 58.5 1.0
C14 D:CYZ1302 2.8 60.9 1.0
O4 D:CYZ1302 3.1 63.2 1.0
S2 D:CYZ1302 3.2 72.9 1.0
N3 D:CYZ1302 3.4 63.5 1.0
N D:ASP760 3.4 71.2 1.0
O D:HOH1403 3.4 55.5 1.0
CA D:ASP760 3.5 73.3 1.0
C D:LEU759 3.7 68.3 1.0
CB D:LEU759 3.8 67.1 1.0
OG A:SER729 3.9 55.2 1.0
CB D:ASP760 3.9 76.7 1.0
OD1 D:ASP760 3.9 77.5 1.0
C11 D:CYZ1302 4.0 66.1 1.0
O D:LEU759 4.1 71.3 1.0
C10 D:CYZ1302 4.1 61.8 1.0
CA D:LEU759 4.4 66.0 1.0
CG D:ASP760 4.4 80.2 1.0
C9 D:CYZ1302 4.6 66.5 1.0
O3 D:CYZ1302 4.8 70.3 1.0
O D:PHE495 4.9 58.1 1.0
C D:ASP760 5.0 76.2 1.0
CD1 D:LEU759 5.0 60.5 1.0

Reference:

T.Nakagawa, X.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3
Page generated: Sun Jul 13 11:36:21 2025

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