Chlorine in PDB 8hfl: Cryo-Em Structure of Human Norepinephrine Transporter Net in the Presence of the Antidepressant Bupropion in An Inward-Open State at Resolution of 3.0 Angstrom.

The binding sites of Chlorine atom in the Cryo-Em Structure of Human Norepinephrine Transporter Net in the Presence of the Antidepressant Bupropion in An Inward-Open State at Resolution of 3.0 Angstrom. (pdb code 8hfl). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Cryo-Em Structure of Human Norepinephrine Transporter Net in the Presence of the Antidepressant Bupropion in An Inward-Open State at Resolution of 3.0 Angstrom., PDB code: 8hfl:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Cryo-Em Structure of Human Norepinephrine Transporter Net in the Presence of the Antidepressant Bupropion in An Inward-Open State at Resolution of 3.0 Angstrom.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Human Norepinephrine Transporter Net in the Presence of the Antidepressant Bupropion in An Inward-Open State at Resolution of 3.0 Angstrom. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl701 b:76.6 occ:1.00 CL1 A:1XR701 0.0 76.6 1.0 C6 A:1XR701 1.7 59.8 1.0 C7 A:1XR701 2.7 61.5 1.0 C5 A:1XR701 2.7 55.0 1.0 CA A:GLY149 3.5 47.5 1.0 OG A:SER420 3.6 54.5 1.0 CA A:SER420 3.7 51.1 1.0 CB A:TYR152 3.9 46.3 1.0 C8 A:1XR701 4.0 61.7 1.0 C4 A:1XR701 4.0 58.8 1.0 O A:SER420 4.1 56.8 1.0 O A:VAL148 4.1 55.2 1.0 CB A:SER420 4.2 53.8 1.0 N A:GLY149 4.3 47.4 1.0 CG A:TYR152 4.3 50.2 1.0 C A:SER420 4.4 53.7 1.0 O A:HOH803 4.4 62.9 1.0 C A:VAL148 4.5 44.7 1.0 C9 A:1XR701 4.5 61.6 1.0 O A:SER419 4.5 62.5 1.0 C A:GLY149 4.6 48.1 1.0 CA A:GLY423 4.6 55.1 1.0 CD1 A:TYR152 4.6 55.2 1.0 N A:SER420 4.7 48.9 1.0 O A:GLY149 4.7 54.9 1.0 CD2 A:TYR152 4.8 51.3 1.0 N A:MET424 4.9 56.2 1.0 C A:SER419 5.0 55.4 1.0 C A:GLY423 5.0 53.5 1.0

Chlorine binding site 2 out of 2 in the Cryo-Em Structure of Human Norepinephrine Transporter Net in the Presence of the Antidepressant Bupropion in An Inward-Open State at Resolution of 3.0 Angstrom.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of Human Norepinephrine Transporter Net in the Presence of the Antidepressant Bupropion in An Inward-Open State at Resolution of 3.0 Angstrom. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl702 b:78.0 occ:1.00 OH A:TYR98 2.6 56.7 1.0 NE2 A:GLN314 2.9 50.9 1.0 ND2 A:ASN78 3.0 61.7 1.0 CB A:SER318 3.2 54.5 1.0 OG A:SER318 3.3 58.2 1.0 OG A:SER354 3.3 52.3 1.0 CZ A:TYR98 3.5 57.1 1.0 CG A:ASN78 3.6 59.2 1.0 CD1 A:PHE82 3.8 46.5 1.0 CD A:GLN314 3.9 48.2 1.0 CE1 A:TYR98 3.9 54.2 1.0 CG A:GLN314 4.0 49.0 1.0 OD1 A:ASN350 4.1 69.8 1.0 OD1 A:ASN78 4.2 57.9 1.0 CA A:ASN78 4.2 48.5 1.0 CB A:PHE82 4.2 43.2 1.0 CG A:PHE82 4.3 47.0 1.0 CB A:ASN78 4.4 53.4 1.0 ND2 A:ASN350 4.4 68.1 1.0 O A:GLN314 4.5 58.2 1.0 CE1 A:PHE82 4.5 47.8 1.0 CB A:SER354 4.5 56.3 1.0 CE2 A:TYR98 4.6 53.4 1.0 N A:ASN78 4.7 49.9 1.0 CG A:ASN350 4.7 67.2 1.0 CA A:SER318 4.7 55.6 1.0 OE1 A:GLN314 5.0 52.4 1.0

J.Tan, Y.Xiao, F.Kong, J.Lei, Y.Yuan, C.Yan. Molecular Basis For the Reuptake and Inhibition of Human Norepinephrine Transporter To Be Published.