Chlorine in PDB 8jv6: Cryo-Em Structures of the Zebrafish P2X4 Receptor in Complex with Bay- 1797

The binding sites of Chlorine atom in the Cryo-Em Structures of the Zebrafish P2X4 Receptor in Complex with Bay- 1797 (pdb code 8jv6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Cryo-Em Structures of the Zebrafish P2X4 Receptor in Complex with Bay- 1797, PDB code: 8jv6:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Cryo-Em Structures of the Zebrafish P2X4 Receptor in Complex with Bay- 1797


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structures of the Zebrafish P2X4 Receptor in Complex with Bay- 1797 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl404 b:79.2 occ:1.00 CL A:P6E404 0.0 79.2 1.0 C24 A:P6E404 1.8 59.4 1.0 C23 A:P6E404 2.7 56.7 1.0 C26 A:P6E404 2.8 57.5 1.0 CG C:PRO96 3.2 53.2 1.0 CG2 A:ILE94 3.3 47.4 1.0 CB A:PHE299 3.4 25.6 1.0 CG A:PHE299 3.4 31.3 1.0 CD2 A:PHE299 3.7 33.7 1.0 CD1 A:PHE299 3.9 35.7 1.0 CB C:PRO96 3.9 43.8 1.0 C22 A:P6E404 4.0 62.5 1.0 C27 A:P6E404 4.0 63.9 1.0 CD C:PRO96 4.4 45.9 1.0 CE2 A:PHE299 4.4 36.5 1.0 CE2 A:PHE297 4.5 29.3 1.0 C28 A:P6E404 4.5 65.3 1.0 CE1 A:PHE299 4.6 33.2 1.0 O17 C:P6E405 4.7 57.0 1.0 O19 C:P6E405 4.7 44.3 1.0 CZ A:PHE299 4.8 34.0 1.0 CB A:ILE94 4.8 41.3 1.0 C28 C:P6E405 4.9 62.9 1.0 CA A:PHE299 4.9 30.6 1.0 O A:ILE94 4.9 61.0 1.0

Chlorine binding site 2 out of 3 in the Cryo-Em Structures of the Zebrafish P2X4 Receptor in Complex with Bay- 1797


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structures of the Zebrafish P2X4 Receptor in Complex with Bay- 1797 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl406 b:76.4 occ:1.00 CL B:P6E406 0.0 76.4 1.0 C24 B:P6E406 1.8 56.5 1.0 C23 B:P6E406 2.7 54.0 1.0 C26 B:P6E406 2.8 55.8 1.0 CG A:PRO96 3.2 49.5 1.0 CG2 B:ILE94 3.4 46.9 1.0 CB B:PHE299 3.4 26.1 1.0 CG B:PHE299 3.5 29.7 1.0 CD2 B:PHE299 3.7 34.9 1.0 CB A:PRO96 4.0 40.6 1.0 CD1 B:PHE299 4.0 33.0 1.0 C22 B:P6E406 4.0 61.6 1.0 C27 B:P6E406 4.0 60.8 1.0 CD A:PRO96 4.3 42.0 1.0 CE2 B:PHE299 4.5 36.9 1.0 C28 B:P6E406 4.5 63.5 1.0 CE2 B:PHE297 4.5 29.1 1.0 O19 A:P6E404 4.6 46.3 1.0 O17 A:P6E404 4.7 62.0 1.0 C28 A:P6E404 4.7 65.3 1.0 CE1 B:PHE299 4.7 35.2 1.0 O B:ILE94 4.8 60.3 1.0 CB B:ILE94 4.9 39.4 1.0 CA B:PHE299 4.9 32.0 1.0 CZ B:PHE299 5.0 34.3 1.0

Chlorine binding site 3 out of 3 in the Cryo-Em Structures of the Zebrafish P2X4 Receptor in Complex with Bay- 1797


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cryo-Em Structures of the Zebrafish P2X4 Receptor in Complex with Bay- 1797 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl405 b:76.3 occ:1.00 CL C:P6E405 0.0 76.3 1.0 C24 C:P6E405 1.8 57.6 1.0 C23 C:P6E405 2.7 55.7 1.0 C26 C:P6E405 2.8 54.4 1.0 CG B:PRO96 3.2 52.2 1.0 CG2 C:ILE94 3.3 46.3 1.0 CB C:PHE299 3.4 26.9 1.0 CG C:PHE299 3.4 30.6 1.0 CD2 C:PHE299 3.7 34.3 1.0 CB B:PRO96 3.8 44.6 1.0 CD1 C:PHE299 3.9 33.5 1.0 C22 C:P6E405 4.0 60.5 1.0 C27 C:P6E405 4.0 60.9 1.0 CE2 C:PHE299 4.4 37.9 1.0 CD B:PRO96 4.5 44.8 1.0 CE2 C:PHE297 4.5 29.4 1.0 C28 C:P6E405 4.5 62.9 1.0 CE1 C:PHE299 4.6 33.6 1.0 O17 B:P6E406 4.7 56.0 1.0 CB C:ILE94 4.8 39.8 1.0 CZ C:PHE299 4.8 36.3 1.0 O C:ILE94 4.8 61.3 1.0 C28 B:P6E406 4.9 63.5 1.0 O19 B:P6E406 4.9 45.5 1.0 CA C:PHE299 4.9 33.7 1.0

M.Hattori, C.Shen. Structural Insights Into the Allosteric Inhibition of P2X4 Receptors Nat Commun 2023.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-023-42164-Y