Chlorine in PDB 8q4p: Crystal Structure of YTHDC1 in Complex with Compound 27 (ZA_309)

The structure of Crystal Structure of YTHDC1 in Complex with Compound 27 (ZA_309), PDB code: 8q4p was solved by R.K.Bedi, F.Zalesak, A.Caflisch, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.78 / 1.43
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	39.85, 103.51, 42.13, 90, 104.56, 90
R / Rfree (%)	20.5 / 23.3

The binding sites of Chlorine atom in the Crystal Structure of YTHDC1 in Complex with Compound 27 (ZA_309) (pdb code 8q4p). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of YTHDC1 in Complex with Compound 27 (ZA_309), PDB code: 8q4p:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of YTHDC1 in Complex with Compound 27 (ZA_309)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of YTHDC1 in Complex with Compound 27 (ZA_309) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl605 b:51.6 occ:1.00 CL01 A:JII605 0.0 51.6 1.0 C02 A:JII605 1.8 42.0 1.0 ND2 A:ASN364 2.7 38.3 1.0 ND2 A:ASN367 2.8 33.6 1.0 N21 A:JII605 2.8 43.3 1.0 N03 A:JII605 2.8 38.3 1.0 N A:ASN363 3.3 30.3 1.0 CG A:ASN364 3.3 35.1 1.0 CB A:ASN363 3.4 38.8 1.0 N A:ASN364 3.5 26.5 1.0 CA A:ASN363 3.7 33.7 1.0 OG A:SER362 3.7 29.7 1.0 O A:VAL429 3.7 45.6 1.0 OD1 A:ASN364 3.7 33.2 1.0 C A:ASN363 3.9 32.6 1.0 CG A:ASN367 3.9 31.8 1.0 CD A:PRO431 4.0 53.9 1.0 C04 A:JII605 4.1 36.5 1.0 C08 A:JII605 4.2 42.4 1.0 CB A:ASN364 4.3 31.9 1.0 C A:SER362 4.3 25.7 1.0 CA A:ASN364 4.4 28.9 1.0 CB A:ASN367 4.4 26.6 1.0 CG A:PRO431 4.5 55.6 1.0 CG A:ASN363 4.6 42.1 1.0 CA A:SER362 4.6 28.6 1.0 C07 A:JII605 4.7 40.5 1.0 O A:ASN364 4.7 28.0 1.0 CB A:SER362 4.7 29.2 1.0 OD1 A:ASN367 4.8 30.9 1.0 C A:VAL429 4.9 45.8 1.0 O A:ASN363 4.9 33.8 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of YTHDC1 in Complex with Compound 27 (ZA_309)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of YTHDC1 in Complex with Compound 27 (ZA_309) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl605 b:47.0 occ:1.00 CL01 B:JII605 0.0 47.0 1.0 C02 B:JII605 1.8 33.5 1.0 N21 B:JII605 2.8 34.9 1.0 N03 B:JII605 2.8 35.7 1.0 ND2 B:ASN367 3.1 29.8 1.0 ND2 B:ASN364 3.3 39.7 1.0 CG B:ASN364 3.4 31.9 1.0 N B:ASN363 3.4 26.6 1.0 OD1 B:ASN364 3.4 34.4 1.0 OG B:SER362 3.5 28.0 1.0 N B:ASN364 3.5 25.5 1.0 CB B:ASN363 3.7 36.3 1.0 CD B:PRO431 3.8 50.0 1.0 CA B:ASN363 3.8 28.4 1.0 CG B:ASN367 3.9 27.3 1.0 C B:ASN363 4.0 26.5 1.0 C04 B:JII605 4.1 30.8 1.0 CB B:ASN367 4.1 23.0 1.0 C08 B:JII605 4.2 34.8 1.0 O B:VAL429 4.2 35.3 1.0 CB B:ASN364 4.3 31.8 1.0 CG B:PRO431 4.3 51.2 1.0 C B:SER362 4.3 26.3 1.0 CA B:ASN364 4.3 30.5 1.0 O B:ASN364 4.5 27.6 1.0 CB B:SER362 4.6 25.4 1.0 CA B:SER362 4.6 26.0 1.0 C07 B:JII605 4.7 31.8 1.0 C B:ASN364 4.9 23.6 1.0 OD1 B:ASN367 4.9 26.9 1.0

R.K.Bedi, F.Zalesak, A.Caflisch. Crystal Structure of YTHDC1 in Complex with Compound 27 (ZA_309) To Be Published.