Chlorine in PDB 8qm5: Potential Drug Binding Sites For Translation Initiation Factor EIF4E

The structure of Potential Drug Binding Sites For Translation Initiation Factor EIF4E, PDB code: 8qm5 was solved by A.Cleasby, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.72 / 1.89
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	47.124, 68.877, 63.729, 90, 96.57, 90
R / Rfree (%)	19.4 / 22

The binding sites of Chlorine atom in the Potential Drug Binding Sites For Translation Initiation Factor EIF4E (pdb code 8qm5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Potential Drug Binding Sites For Translation Initiation Factor EIF4E, PDB code: 8qm5:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Potential Drug Binding Sites For Translation Initiation Factor EIF4E


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Potential Drug Binding Sites For Translation Initiation Factor EIF4E within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:44.8 occ:0.69 CL13 A:W4U301 0.0 44.8 0.7 C12 A:W4U301 1.7 43.5 0.7 C14 A:W4U301 2.7 42.9 0.7 C11 A:W4U301 2.7 43.0 0.7 H26 A:W4U301 2.8 42.9 0.7 H25 A:W4U301 2.8 43.0 0.7 CD2 A:LEU45 3.8 35.4 1.0 CA A:TYR76 3.9 36.5 1.0 C15 A:W4U301 4.0 42.8 0.7 C10 A:W4U301 4.0 43.0 0.7 CD1 A:TYR76 4.0 37.4 1.0 CB A:ILE79 4.1 48.4 1.0 CG1 A:ILE79 4.2 49.0 1.0 CG2 A:ILE79 4.2 48.5 1.0 CD1 A:LEU45 4.2 30.3 1.0 CB A:TYR76 4.4 36.4 1.0 CD1 A:LEU134 4.4 32.8 1.0 C9 A:W4U301 4.5 43.5 0.7 NE1 A:TRP130 4.5 29.4 1.0 N A:TYR76 4.6 35.6 1.0 CG A:TYR76 4.6 36.2 1.0 CG A:LEU45 4.6 31.8 1.0 H27 A:W4U301 4.7 42.8 0.7 H24 A:W4U301 4.7 43.0 0.7 O A:TYR76 4.7 38.4 1.0 O A:LEU75 4.8 34.0 1.0 CE1 A:TYR76 4.9 37.5 1.0 C A:TYR76 4.9 38.4 1.0 C A:LEU75 4.9 35.1 1.0

Chlorine binding site 2 out of 2 in the Potential Drug Binding Sites For Translation Initiation Factor EIF4E


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Potential Drug Binding Sites For Translation Initiation Factor EIF4E within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl302 b:45.6 occ:0.76 CL13 B:W4U302 0.0 45.6 0.8 C12 B:W4U302 1.7 42.9 0.8 C14 B:W4U302 2.7 41.7 0.8 C11 B:W4U302 2.7 41.4 0.8 H26 B:W4U302 2.8 41.7 0.8 H25 B:W4U302 2.8 41.4 0.8 CD2 B:LEU45 3.6 35.8 1.0 C15 B:W4U302 4.0 41.4 0.8 C10 B:W4U302 4.0 41.0 0.8 CB B:ILE79 4.0 42.8 1.0 CD1 B:LEU45 4.0 33.6 1.0 CG1 B:ILE79 4.0 43.2 1.0 CA B:TYR76 4.0 34.9 1.0 CD1 B:TYR76 4.2 37.8 1.0 CG2 B:ILE79 4.2 43.5 1.0 NE1 B:TRP130 4.4 37.3 1.0 CD1 B:LEU134 4.4 34.0 1.0 CG B:LEU45 4.5 33.9 1.0 C9 B:W4U302 4.5 42.4 0.8 CB B:TYR76 4.6 36.4 1.0 N B:TYR76 4.7 33.3 1.0 H27 B:W4U302 4.7 41.4 0.8 H24 B:W4U302 4.7 41.0 0.8 CG B:TYR76 4.8 36.9 1.0 O B:LEU75 4.8 34.8 1.0 O B:TYR76 4.8 36.0 1.0 C B:LEU75 5.0 34.3 1.0 C B:TYR76 5.0 36.0 1.0

Y.S.Sharp, M.Martella, C.I.Milton, G.Ward, A.J.Woodhead, C.J.Richardson, M.G.Carr, E.Chiarparin, B.D.Cons, J.Coyle, S.D'agostino, C.E.East, S.D.Hiscock, C.Martinez-Fleites, P.N.Mortenson, N.Palmer, P.Pathuri, M.V.Powers, S.M.Saalau, J.D.St.Denis, K.Swabey, M.Vinkovic, G.Williams, P.A.Clarke. Integrating Fragment-Based Screening with Targeted Protein Degradation and Genetic Rescue to Explore EIF4E Function Nat Commun 2025.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-024-54356-1