Chlorine in PDB 8r5h: Ubiquitin Ligation to Neosubstrate By A Cullin-Ring E3 Ligase & CDC34: NEDD8-CUL2-RBX1-Elob/C-Vhl-MZ1 with Trapped UBE2R2~Donor Ub-BRD4 BD2

Enzymatic activity of Ubiquitin Ligation to Neosubstrate By A Cullin-Ring E3 Ligase & CDC34: NEDD8-CUL2-RBX1-Elob/C-Vhl-MZ1 with Trapped UBE2R2~Donor Ub-BRD4 BD2

All present enzymatic activity of Ubiquitin Ligation to Neosubstrate By A Cullin-Ring E3 Ligase & CDC34: NEDD8-CUL2-RBX1-Elob/C-Vhl-MZ1 with Trapped UBE2R2~Donor Ub-BRD4 BD2:
2.3.2.23;

Other elements in 8r5h:

The structure of Ubiquitin Ligation to Neosubstrate By A Cullin-Ring E3 Ligase & CDC34: NEDD8-CUL2-RBX1-Elob/C-Vhl-MZ1 with Trapped UBE2R2~Donor Ub-BRD4 BD2 also contains other interesting chemical elements:

Zinc

(Zn)

3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Ubiquitin Ligation to Neosubstrate By A Cullin-Ring E3 Ligase & CDC34: NEDD8-CUL2-RBX1-Elob/C-Vhl-MZ1 with Trapped UBE2R2~Donor Ub-BRD4 BD2 (pdb code 8r5h). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Ubiquitin Ligation to Neosubstrate By A Cullin-Ring E3 Ligase & CDC34: NEDD8-CUL2-RBX1-Elob/C-Vhl-MZ1 with Trapped UBE2R2~Donor Ub-BRD4 BD2, PDB code: 8r5h:

Chlorine binding site 1 out of 1 in 8r5h

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Chlorine Binding Sites List in 8r5h

Chlorine binding site 1 out of 1 in the Ubiquitin Ligation to Neosubstrate By A Cullin-Ring E3 Ligase & CDC34: NEDD8-CUL2-RBX1-Elob/C-Vhl-MZ1 with Trapped UBE2R2~Donor Ub-BRD4 BD2

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Ubiquitin Ligation to Neosubstrate By A Cullin-Ring E3 Ligase & CDC34: NEDD8-CUL2-RBX1-Elob/C-Vhl-MZ1 with Trapped UBE2R2~Donor Ub-BRD4 BD2 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
H:Cl301 b:57.0 occ:1.00	CL1	H:759301	0.0	57.0	1.0
	CBY	H:759301	1.7	57.0	1.0
	CAO	H:759301	2.7	57.0	1.0
	CAN	H:759301	2.7	57.0	1.0
	CE	F:MET442	3.9	60.9	1.0
	CAS	H:759301	4.0	57.0	1.0
	CAR	H:759301	4.0	57.0	1.0
	CB	F:GLU438	4.2	64.6	1.0
	CZ2	F:TRP374	4.4	57.1	1.0
	CCE	H:759301	4.5	57.0	1.0
	OH	H:TYR112	4.5	54.1	1.0
	CG	F:GLU438	4.9	64.6	1.0

Reference:

J.Liwocha, J.R.Prabu, G.Kleiger, B.A.Schulman. Cullin-Ring Ligases Target Substrates with Geometrically Optimized Catalytic Partners Mol.Cell 2024.
ISSN: ISSN 1097-2765
DOI: 10.1016/J.MOLCEL.2024.01.022

Page generated: Tue Jul 30 12:07:33 2024

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