Chlorine in PDB 8t7o: Crystal Structure of the R132H Mutant of IDH1 Bound to Ag-120

All present enzymatic activity of Crystal Structure of the R132H Mutant of IDH1 Bound to Ag-120:
1.1.1.42;

The structure of Crystal Structure of the R132H Mutant of IDH1 Bound to Ag-120, PDB code: 8t7o was solved by J.Lu, P.Abeywickrema, M.R.Heo, G.Parthasarathy, M.Mccoy, S.M.Soisson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.37 / 2.05
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	79.445, 79.445, 305.312, 90, 90, 90
R / Rfree (%)	22.4 / 25.5

The structure of Crystal Structure of the R132H Mutant of IDH1 Bound to Ag-120 also contains other interesting chemical elements:

Fluorine

(F)

3 atoms

The binding sites of Chlorine atom in the Crystal Structure of the R132H Mutant of IDH1 Bound to Ag-120 (pdb code 8t7o). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the R132H Mutant of IDH1 Bound to Ag-120, PDB code: 8t7o:

Chlorine binding site 1 out of 1 in the Crystal Structure of the R132H Mutant of IDH1 Bound to Ag-120


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the R132H Mutant of IDH1 Bound to Ag-120 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl502 b:70.6 occ:1.00 CL A:IV3502 0.0 70.6 1.0 C10 A:IV3502 1.7 71.8 1.0 C9 A:IV3502 2.7 72.1 1.0 C5 A:IV3502 2.7 72.7 1.0 C4 A:IV3502 3.1 73.5 1.0 N1 A:IV3502 3.4 74.0 1.0 C15 A:IV3502 3.5 73.0 1.0 CH2 B:TRP267 3.7 47.4 1.0 C11 A:IV3502 3.8 73.3 1.0 CG1 A:VAL276 3.9 92.6 1.0 C8 A:IV3502 4.0 72.3 1.0 C16 A:IV3502 4.0 74.8 1.0 CG2 B:VAL255 4.0 62.2 1.0 C6 A:IV3502 4.0 72.7 1.0 O1 A:IV3502 4.0 74.5 1.0 CB A:SER280 4.0 79.7 1.0 O A:VAL276 4.1 89.2 1.0 CZ3 B:TRP267 4.1 47.2 1.0 C7 A:IV3502 4.5 72.5 1.0 C22 A:IV3502 4.5 77.7 1.0 N4 A:IV3502 4.5 77.5 1.0 CG1 B:VAL255 4.5 62.0 1.0 C3 A:IV3502 4.6 73.6 1.0 C14 A:IV3502 4.6 72.9 1.0 OG A:SER280 4.7 81.6 1.0 CB B:VAL255 4.7 61.6 1.0 CZ2 B:TRP267 4.7 47.4 1.0 C A:VAL276 4.8 89.3 1.0 F2 A:IV3502 4.9 72.9 1.0

M.A.Mccoy, J.Lu, R.Miller, S.M.Soisson, M.H.Lam, C.Fischer. Mechanistic and Biostructural Studies of Mutant IDH1 To Be Published.