Chlorine in PDB 8tf3: Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Chlorine atom in the Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole (pdb code 8tf3). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 12 binding sites of Chlorine where determined in the Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole, PDB code: 8tf3:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 12 in the Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl804 b:89.4 occ:1.00 CL4 A:ECN804 0.0 89.4 1.0 C14 A:ECN804 1.7 78.5 1.0 C15 A:ECN804 2.7 75.8 1.0 C5 A:ECN804 2.7 74.1 1.0 C20 A:ECN804 3.1 76.1 1.0 CZ A:PHE472 3.5 61.2 1.0 C16 A:ECN804 4.0 80.5 1.0 C21 A:ECN804 4.0 71.6 1.0 C8 A:ECN804 4.0 76.2 1.0 OG A:SER334 4.0 67.7 1.0 O A:CYS330 4.1 63.8 1.0 O20 A:ECN804 4.1 78.0 1.0 C19 A:ECN804 4.1 75.2 1.0 CB A:ALA333 4.2 48.9 1.0 CE1 A:PHE472 4.2 64.5 1.0 CE2 A:PHE472 4.3 60.3 1.0 CA A:CYS330 4.4 57.1 1.0 C17 A:ECN804 4.5 74.6 1.0 CB A:CYS330 4.5 56.9 1.0 C A:CYS330 4.7 53.6 1.0 SG A:CYS330 4.8 83.7 1.0 N A:SER334 4.8 52.2 1.0

Chlorine binding site 2 out of 12 in the Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl804 b:88.1 occ:1.00 CL2 A:ECN804 0.0 88.1 1.0 C11 A:ECN804 1.7 71.1 1.0 C13 A:ECN804 2.7 73.2 1.0 C9 A:ECN804 2.7 71.6 1.0 CG D:LEU496 3.6 52.1 1.0 CG A:MET466 3.7 46.4 1.0 CA A:MET466 3.7 53.6 1.0 CG2 D:VAL499 3.8 47.6 1.0 CA D:LEU496 3.9 53.5 1.0 C2 A:ECN804 4.0 74.3 1.0 C10 A:ECN804 4.0 70.9 1.0 CD1 D:LEU496 4.1 59.2 1.0 CG1 D:VAL499 4.1 52.5 1.0 N A:MET466 4.1 46.9 1.0 O D:TRP495 4.1 61.4 1.0 CB A:MET466 4.1 43.9 1.0 CB D:LEU496 4.2 53.0 1.0 O A:VAL465 4.3 66.7 1.0 C A:VAL465 4.4 52.1 1.0 N D:LEU496 4.4 55.5 1.0 C1 A:ECN804 4.5 74.5 1.0 C D:TRP495 4.5 57.9 1.0 CB A:ALA469 4.5 44.2 1.0 CB D:VAL499 4.6 47.7 1.0 CD2 D:LEU496 4.6 55.9 1.0 CG1 A:VAL465 4.9 52.4 1.0 SD A:MET466 4.9 75.8 1.0 C A:MET466 4.9 62.4 1.0

Chlorine binding site 3 out of 12 in the Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl804 b:90.8 occ:1.00 CL8 A:ECN804 0.0 90.8 1.0 C16 A:ECN804 1.7 80.5 1.0 C15 A:ECN804 2.7 75.8 1.0 C17 A:ECN804 2.7 74.6 1.0 C14 A:ECN804 4.0 78.5 1.0 C21 A:ECN804 4.0 71.6 1.0 CG2 A:ILE337 4.0 48.4 1.0 CA A:SER334 4.2 53.3 1.0 OG A:SER334 4.2 67.7 1.0 CB A:ILE337 4.3 53.7 1.0 CB A:SER334 4.3 57.5 1.0 CD1 A:ILE337 4.4 48.9 1.0 C5 A:ECN804 4.5 74.1 1.0 O A:SER334 4.6 66.7 1.0 C A:SER334 4.9 58.2 1.0 CG1 A:ILE337 5.0 47.8 1.0

Chlorine binding site 4 out of 12 in the Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl805 b:89.4 occ:1.00 CL4 B:ECN805 0.0 89.4 1.0 C14 B:ECN805 1.7 78.5 1.0 C15 B:ECN805 2.7 75.8 1.0 C5 B:ECN805 2.7 74.1 1.0 C20 B:ECN805 3.1 76.1 1.0 CZ B:PHE472 3.5 61.2 1.0 C16 B:ECN805 4.0 80.5 1.0 C21 B:ECN805 4.0 71.6 1.0 C8 B:ECN805 4.0 76.2 1.0 OG B:SER334 4.0 67.7 1.0 O B:CYS330 4.1 63.8 1.0 O20 B:ECN805 4.1 78.0 1.0 C19 B:ECN805 4.1 75.2 1.0 CB B:ALA333 4.2 48.9 1.0 CE1 B:PHE472 4.2 64.5 1.0 CE2 B:PHE472 4.3 60.3 1.0 CA B:CYS330 4.4 57.1 1.0 C17 B:ECN805 4.5 74.6 1.0 CB B:CYS330 4.5 56.9 1.0 C B:CYS330 4.7 53.6 1.0 SG B:CYS330 4.8 83.7 1.0 N B:SER334 4.8 52.2 1.0

Chlorine binding site 5 out of 12 in the Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl805 b:88.1 occ:1.00 CL2 B:ECN805 0.0 88.1 1.0 C11 B:ECN805 1.7 71.1 1.0 C13 B:ECN805 2.7 73.2 1.0 C9 B:ECN805 2.7 71.6 1.0 CG A:LEU496 3.6 52.1 1.0 CG B:MET466 3.7 46.4 1.0 CA B:MET466 3.7 53.6 1.0 CG2 A:VAL499 3.8 47.6 1.0 CA A:LEU496 3.9 53.5 1.0 C2 B:ECN805 4.0 74.3 1.0 C10 B:ECN805 4.0 70.9 1.0 CD1 A:LEU496 4.1 59.2 1.0 CG1 A:VAL499 4.1 52.5 1.0 N B:MET466 4.1 46.9 1.0 O A:TRP495 4.1 61.4 1.0 CB B:MET466 4.1 43.9 1.0 CB A:LEU496 4.2 53.0 1.0 O B:VAL465 4.3 66.7 1.0 C B:VAL465 4.4 52.1 1.0 N A:LEU496 4.4 55.5 1.0 C1 B:ECN805 4.5 74.5 1.0 C A:TRP495 4.5 57.9 1.0 CB B:ALA469 4.5 44.2 1.0 CB A:VAL499 4.6 47.7 1.0 CD2 A:LEU496 4.6 55.9 1.0 CG1 B:VAL465 4.9 52.4 1.0 SD B:MET466 4.9 75.8 1.0 C B:MET466 4.9 62.4 1.0

Chlorine binding site 6 out of 12 in the Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl805 b:90.8 occ:1.00 CL8 B:ECN805 0.0 90.8 1.0 C16 B:ECN805 1.7 80.5 1.0 C15 B:ECN805 2.7 75.8 1.0 C17 B:ECN805 2.7 74.6 1.0 C14 B:ECN805 4.0 78.5 1.0 C21 B:ECN805 4.0 71.6 1.0 CG2 B:ILE337 4.0 48.4 1.0 CA B:SER334 4.2 53.3 1.0 OG B:SER334 4.2 67.7 1.0 CB B:ILE337 4.3 53.7 1.0 CB B:SER334 4.3 57.5 1.0 CD1 B:ILE337 4.4 48.9 1.0 C5 B:ECN805 4.5 74.1 1.0 O B:SER334 4.6 66.7 1.0 C B:SER334 4.9 58.2 1.0 CG1 B:ILE337 5.0 47.8 1.0

Chlorine binding site 7 out of 12 in the Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl805 b:89.4 occ:1.00 CL4 C:ECN805 0.0 89.4 1.0 C14 C:ECN805 1.7 78.5 1.0 C15 C:ECN805 2.7 75.8 1.0 C5 C:ECN805 2.7 74.1 1.0 C20 C:ECN805 3.1 76.1 1.0 CZ C:PHE472 3.5 61.2 1.0 C16 C:ECN805 4.0 80.5 1.0 C21 C:ECN805 4.0 71.6 1.0 C8 C:ECN805 4.0 76.2 1.0 OG C:SER334 4.0 67.7 1.0 O C:CYS330 4.1 63.8 1.0 O20 C:ECN805 4.1 78.0 1.0 C19 C:ECN805 4.1 75.2 1.0 CB C:ALA333 4.2 48.9 1.0 CE1 C:PHE472 4.2 64.5 1.0 CE2 C:PHE472 4.3 60.3 1.0 CA C:CYS330 4.4 57.1 1.0 C17 C:ECN805 4.5 74.6 1.0 CB C:CYS330 4.5 56.9 1.0 C C:CYS330 4.7 53.6 1.0 SG C:CYS330 4.8 83.7 1.0 N C:SER334 4.8 52.2 1.0

Chlorine binding site 8 out of 12 in the Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl805 b:88.1 occ:1.00 CL2 C:ECN805 0.0 88.1 1.0 C11 C:ECN805 1.7 71.1 1.0 C13 C:ECN805 2.7 73.2 1.0 C9 C:ECN805 2.7 71.6 1.0 CG B:LEU496 3.6 52.1 1.0 CG C:MET466 3.7 46.4 1.0 CA C:MET466 3.7 53.6 1.0 CG2 B:VAL499 3.8 47.6 1.0 CA B:LEU496 3.9 53.5 1.0 C2 C:ECN805 4.0 74.3 1.0 C10 C:ECN805 4.0 70.9 1.0 CD1 B:LEU496 4.1 59.2 1.0 CG1 B:VAL499 4.1 52.5 1.0 N C:MET466 4.1 46.9 1.0 O B:TRP495 4.1 61.4 1.0 CB C:MET466 4.1 43.9 1.0 CB B:LEU496 4.2 53.0 1.0 O C:VAL465 4.3 66.7 1.0 C C:VAL465 4.4 52.1 1.0 N B:LEU496 4.4 55.5 1.0 C1 C:ECN805 4.5 74.5 1.0 C B:TRP495 4.5 57.9 1.0 CB C:ALA469 4.5 44.2 1.0 CB B:VAL499 4.6 47.7 1.0 CD2 B:LEU496 4.6 55.9 1.0 CG1 C:VAL465 4.9 52.4 1.0 SD C:MET466 4.9 75.8 1.0 C C:MET466 4.9 62.4 1.0

Chlorine binding site 9 out of 12 in the Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl805 b:90.8 occ:1.00 CL8 C:ECN805 0.0 90.8 1.0 C16 C:ECN805 1.7 80.5 1.0 C15 C:ECN805 2.7 75.8 1.0 C17 C:ECN805 2.7 74.6 1.0 C14 C:ECN805 4.0 78.5 1.0 C21 C:ECN805 4.0 71.6 1.0 CG2 C:ILE337 4.0 48.4 1.0 CA C:SER334 4.2 53.3 1.0 OG C:SER334 4.2 67.7 1.0 CB C:ILE337 4.3 53.7 1.0 CB C:SER334 4.3 57.5 1.0 CD1 C:ILE337 4.4 48.9 1.0 C5 C:ECN805 4.5 74.1 1.0 O C:SER334 4.6 66.7 1.0 C C:SER334 4.9 58.2 1.0 CG1 C:ILE337 5.0 47.8 1.0

Chlorine binding site 10 out of 12 in the Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Wildtype Rabbit TRPV5 Into Nanodiscs in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl805 b:89.4 occ:1.00 CL4 D:ECN805 0.0 89.4 1.0 C14 D:ECN805 1.7 78.5 1.0 C15 D:ECN805 2.7 75.8 1.0 C5 D:ECN805 2.7 74.1 1.0 C20 D:ECN805 3.1 76.1 1.0 CZ D:PHE472 3.5 61.2 1.0 C16 D:ECN805 4.0 80.5 1.0 C21 D:ECN805 4.0 71.6 1.0 C8 D:ECN805 4.0 76.2 1.0 OG D:SER334 4.0 67.7 1.0 O D:CYS330 4.1 63.8 1.0 O20 D:ECN805 4.1 78.0 1.0 C19 D:ECN805 4.1 75.2 1.0 CB D:ALA333 4.2 48.9 1.0 CE1 D:PHE472 4.2 64.5 1.0 CE2 D:PHE472 4.3 60.3 1.0 CA D:CYS330 4.4 57.1 1.0 CB D:CYS330 4.5 56.9 1.0 C17 D:ECN805 4.5 74.6 1.0 C D:CYS330 4.7 53.6 1.0 SG D:CYS330 4.8 83.7 1.0 N D:SER334 4.8 52.2 1.0

J.J.De Jesus-Perez, M.Gabrielle, S.Raheem, E.C.Fluck, T.Rohacs, V.Y.Moiseenkova-Bell. Structural Mechanism of TRPV5 Inhibition By Econazole. Structure 2023.
ISSN: ISSN 0969-2126
PubMed: 38141613
DOI: 10.1016/J.STR.2023.11.012