Chlorine in PDB 8thh: Cryo-Em Structure of NAV1.7 with Ltg

The binding sites of Chlorine atom in the Cryo-Em Structure of NAV1.7 with Ltg (pdb code 8thh). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Cryo-Em Structure of NAV1.7 with Ltg, PDB code: 8thh:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Cryo-Em Structure of NAV1.7 with Ltg


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of NAV1.7 with Ltg within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2003 b:104.8 occ:1.00 CL01 A:IYJ2003 0.0 104.8 1.0 C10 A:IYJ2003 1.8 101.8 1.0 C13 A:IYJ2003 2.7 101.6 1.0 C08 A:IYJ2003 2.8 98.0 1.0 C09 A:IYJ2003 3.1 106.3 1.0 CL02 A:IYJ2003 3.2 117.5 1.0 C12 A:IYJ2003 3.6 103.7 1.0 N03 A:IYJ2003 3.7 102.1 1.0 N05 A:IYJ2003 3.8 97.2 1.0 C15 A:IYJ2003 4.0 93.9 1.0 C11 A:IYJ2003 4.0 90.5 1.0 CG2 A:VAL1752 4.3 84.8 1.0 N04 A:IYJ2003 4.5 99.0 1.0 C14 A:IYJ2003 4.6 97.4 1.0 N06 A:IYJ2003 4.6 98.1 1.0 C16 A:IYJ2003 4.8 96.0 1.0

Chlorine binding site 2 out of 4 in the Cryo-Em Structure of NAV1.7 with Ltg


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of NAV1.7 with Ltg within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2003 b:117.5 occ:1.00 CL02 A:IYJ2003 0.0 117.5 1.0 C13 A:IYJ2003 1.8 101.6 1.0 C15 A:IYJ2003 2.7 93.9 1.0 C10 A:IYJ2003 2.7 101.8 1.0 CL01 A:IYJ2003 3.2 104.8 1.0 CG2 A:VAL1752 3.5 84.8 1.0 CE1 A:PHE391 3.7 85.4 1.0 CZ A:PHE391 3.8 87.4 1.0 CA A:THR1696 4.0 75.6 1.0 O A:THR1696 4.0 84.7 1.0 C14 A:IYJ2003 4.0 97.4 1.0 C08 A:IYJ2003 4.0 98.0 1.0 C A:THR1696 4.2 76.8 1.0 O A:THR1695 4.5 75.5 1.0 CB A:THR1696 4.5 74.5 1.0 C11 A:IYJ2003 4.5 90.5 1.0 NE2 A:GLN360 4.6 77.5 1.0

Chlorine binding site 3 out of 4 in the Cryo-Em Structure of NAV1.7 with Ltg


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cryo-Em Structure of NAV1.7 with Ltg within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2004 b:145.0 occ:1.00 CL01 A:IYJ2004 0.0 145.0 1.0 C10 A:IYJ2004 1.8 142.2 1.0 C08 A:IYJ2004 2.7 141.6 1.0 C13 A:IYJ2004 2.8 141.8 1.0 C09 A:IYJ2004 3.0 142.2 1.0 CL02 A:IYJ2004 3.2 144.5 1.0 N03 A:IYJ2004 3.3 139.4 1.0 C12 A:IYJ2004 3.7 142.7 1.0 CD2 A:LEU968 4.0 104.3 1.0 C11 A:IYJ2004 4.0 142.7 1.0 C15 A:IYJ2004 4.0 138.3 1.0 N05 A:IYJ2004 4.1 138.7 1.0 N06 A:IYJ2004 4.2 138.9 1.0 N04 A:IYJ2004 4.5 143.7 1.0 C14 A:IYJ2004 4.5 140.4 1.0 C16 A:IYJ2004 4.6 140.8 1.0 ND2 A:ASN1461 4.8 101.4 1.0

Chlorine binding site 4 out of 4 in the Cryo-Em Structure of NAV1.7 with Ltg


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Cryo-Em Structure of NAV1.7 with Ltg within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2004 b:144.5 occ:1.00 CL02 A:IYJ2004 0.0 144.5 1.0 C13 A:IYJ2004 1.8 141.8 1.0 C10 A:IYJ2004 2.8 142.2 1.0 C15 A:IYJ2004 2.8 138.3 1.0 CL01 A:IYJ2004 3.2 145.0 1.0 C08 A:IYJ2004 4.0 141.6 1.0 C14 A:IYJ2004 4.0 140.4 1.0 C11 A:IYJ2004 4.6 142.7 1.0 ND2 A:ASN1461 4.7 101.4 1.0

J.Huang, X.Fan, X.Jin, L.Teng, N.Yan. Dual-Pocket Inhibition of Na V Channels By the Antiepileptic Drug Lamotrigine. Proc.Natl.Acad.Sci.Usa V. 120 73120 2023.
ISSN: ESSN 1091-6490
PubMed: 37782796
DOI: 10.1073/PNAS.2309773120