Chlorine in PDB 8up4: Crystal Structure of LSD18 (A Flavin-Dependent Monooxygenase)

The structure of Crystal Structure of LSD18 (A Flavin-Dependent Monooxygenase), PDB code: 8up4 was solved by Q.Wang, X.Chen, C.Y.Kim, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.75 / 1.51
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	46.354, 61.79, 75.355, 74.64, 81.7, 77.11
R / Rfree (%)	14 / 17.9

The binding sites of Chlorine atom in the Crystal Structure of LSD18 (A Flavin-Dependent Monooxygenase) (pdb code 8up4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of LSD18 (A Flavin-Dependent Monooxygenase), PDB code: 8up4:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of LSD18 (A Flavin-Dependent Monooxygenase)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of LSD18 (A Flavin-Dependent Monooxygenase) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl502 b:22.1 occ:1.00 OG A:SER309 3.0 20.2 1.0 O A:HOH826 3.2 29.7 1.0 O A:HOH884 3.4 37.5 1.0 CA A:GLN66 3.5 16.6 1.0 CB A:SER309 3.5 17.8 1.0 N A:GLN66 3.6 17.1 1.0 CB A:GLN66 3.8 16.7 1.0 C A:PRO65 3.8 18.2 1.0 O A:PRO65 4.0 18.4 1.0 C8M A:FAD501 4.0 17.0 1.0 CB A:PRO65 4.1 20.9 1.0 CD2 A:HIS69 4.1 14.8 1.0 OG A:SER311 4.2 23.6 1.0 CG A:PRO65 4.3 20.5 1.0 NE2 A:HIS69 4.3 15.7 1.0 CB A:SER311 4.4 19.6 1.0 C7M A:FAD501 4.5 15.9 1.0 CA A:SER309 4.6 18.3 1.0 CA A:PRO65 4.6 18.2 1.0 O A:HOH602 4.6 38.6 1.0 C A:GLN66 4.8 15.2 1.0 O B:HOH806 4.9 27.1 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of LSD18 (A Flavin-Dependent Monooxygenase)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of LSD18 (A Flavin-Dependent Monooxygenase) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl502 b:25.5 occ:1.00 OG B:SER309 3.1 20.0 1.0 O B:HOH888 3.1 39.0 1.0 O B:HOH855 3.3 38.5 1.0 CA B:GLN66 3.5 17.2 1.0 CB B:SER309 3.6 20.1 1.0 N B:GLN66 3.7 18.1 1.0 CB B:GLN66 3.8 16.2 1.0 C B:PRO65 3.9 19.8 1.0 O B:PRO65 3.9 22.2 1.0 C8M B:FAD501 4.0 18.9 1.0 CD2 B:HIS69 4.1 18.8 1.0 OG B:SER311 4.2 25.9 1.0 NE2 B:HIS69 4.3 19.3 1.0 CB B:PRO65 4.3 21.1 1.0 CB B:SER311 4.3 22.6 1.0 CG B:PRO65 4.4 21.8 1.0 C7M B:FAD501 4.5 19.1 1.0 CA B:SER309 4.6 19.6 1.0 CA B:PRO65 4.7 20.5 1.0 O B:HOH813 4.8 34.8 1.0 C B:GLN66 4.8 17.5 1.0

Q.Wang, X.Chen, C.Y.Kim. Structural Basis For the Stereoselective Epoxidation Catalyzed By LSD18 in the Polyether Lasalocid Biosynthesis To Be Published.