Chlorine in PDB 8vz7: Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan

Enzymatic activity of Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan

All present enzymatic activity of Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan:
1.14.14.1; 1.14.14.51; 1.14.14.52; 1.14.14.53;

Protein crystallography data

The structure of Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan, PDB code: 8vz7 was solved by M.B.Shah, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.01 / 2.53
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 74.89, 142.17, 163.07, 90, 90, 90
R / Rfree (%) 15.1 / 21.5

Other elements in 8vz7:

The structure of Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan also contains other interesting chemical elements:

Potassium (K) 1 atom
Iron (Fe) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan (pdb code 8vz7). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan, PDB code: 8vz7:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 8vz7

Go back to Chlorine Binding Sites List in 8vz7
Chlorine binding site 1 out of 2 in the Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl502

b:56.3
occ:1.00
 CL A:LSN502 0.0 56.3 1.0
C17 A:LSN502 1.8 49.4 1.0
N6 A:LSN502 2.8 49.0 1.0
C15 A:LSN502 2.9 49.7 1.0
C16 A:LSN502 3.4 51.8 1.0
ND2 A:ASN204 3.7 47.7 1.0
CG2 A:VAL237 3.8 61.6 1.0
CB A:LEU233 3.8 50.1 1.0
CB A:ALA106 3.8 57.6 1.0
C18 A:LSN502 4.0 49.4 1.0
N5 A:LSN502 4.0 47.7 1.0
O A:ALA106 4.0 60.1 1.0
CD2 A:LEU233 4.1 46.6 1.0
CG A:LEU233 4.3 52.2 1.0
CD1 A:LEU233 4.4 52.0 1.0
O A:LEU233 4.4 47.3 1.0
C A:LEU233 4.5 51.4 1.0
CD1 A:LEU208 4.5 47.1 1.0
CA A:LEU233 4.6 49.4 1.0
CG A:ASN204 4.6 46.0 1.0
CA A:ALA106 4.7 57.7 1.0
O A:HOH631 4.7 56.4 1.0
CD2 A:LEU208 4.8 47.3 1.0
C A:ALA106 4.8 56.1 1.0
O A:LSN502 4.8 53.8 1.0
CB A:ASN204 5.0 40.9 1.0
CG A:LEU208 5.0 49.1 1.0

Chlorine binding site 2 out of 2 in 8vz7

Go back to Chlorine Binding Sites List in 8vz7
Chlorine binding site 2 out of 2 in the Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl503

b:88.3
occ:1.00
 CL A:LSN503 0.0 88.3 1.0
C17 A:LSN503 1.8 65.0 1.0
N6 A:LSN503 2.7 66.4 1.0
C15 A:LSN503 2.9 53.7 1.0
NZ A:LYS235 3.2 92.7 1.0
CD A:LYS232 3.5 60.2 1.0
C16 A:LSN503 3.6 67.2 1.0
NZ A:LYS232 3.8 63.7 1.0
C18 A:LSN503 3.9 64.5 1.0
CE A:LYS232 4.0 61.2 1.0
N5 A:LSN503 4.0 59.1 1.0
CD A:LYS235 4.0 90.2 1.0
CE A:LYS235 4.2 94.9 1.0
CB A:LYS232 4.4 47.2 1.0
CG A:LYS232 4.5 53.8 1.0
CA A:LYS232 4.5 47.5 1.0
CG A:LYS235 4.8 79.6 1.0
O A:LSN503 4.9 60.8 1.0

Reference:

S.J.Parikh, S.Edara, S.Deodhar, A.K.Singh, K.Maekawa, Q.Zhang, K.C.Glass, M.B.Shah. Structural and Biophysical Analysis of Cytochrome P450 2C9*14 and *27 Variants in Complex with Losartan J.Inorg.Biochem. 2024.
ISSN: ISSN 0162-0134
DOI: 10.1016/J.JINORGBIO.2024.112622
Page generated: Tue Jul 30 13:44:19 2024

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