Chlorine in PDB 8w7c: Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality
Enzymatic activity of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality
All present enzymatic activity of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality:
3.4.21.92;
Protein crystallography data
The structure of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality, PDB code: 8w7c
was solved by
J.-X.Jiang,
H.Ding,
M.-L.Lu,
M.-R.Chen,
H.-Y.Sun,
Y.-B.Xiao,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
46.20 /
3.00
|
Space group
|
C 1 2 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
142.245,
153.591,
104.617,
90,
117.96,
90
|
R / Rfree (%)
|
24 /
26
|
Other elements in 8w7c:
The structure of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality
(pdb code 8w7c). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 7 binding sites of Chlorine where determined in the
Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality, PDB code: 8w7c:
Jump to Chlorine binding site number:
1;
2;
3;
4;
5;
6;
7;
Chlorine binding site 1 out
of 7 in 8w7c
Go back to
Chlorine Binding Sites List in 8w7c
Chlorine binding site 1 out
of 7 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl301
b:72.7
occ:1.00
|
CL19
|
A:R89301
|
0.0
|
72.7
|
1.0
|
C13
|
A:R89301
|
1.8
|
66.5
|
1.0
|
C18
|
A:R89301
|
2.9
|
66.6
|
1.0
|
C14
|
A:R89301
|
2.9
|
69.2
|
1.0
|
CG2
|
F:ILE100
|
3.3
|
52.4
|
1.0
|
CG1
|
A:VAL148
|
3.5
|
65.6
|
1.0
|
CD2
|
A:TYR118
|
3.6
|
55.7
|
1.0
|
CE2
|
A:TYR118
|
3.8
|
56.0
|
1.0
|
CG
|
A:TYR118
|
3.9
|
56.3
|
1.0
|
CB
|
A:VAL148
|
4.1
|
67.5
|
1.0
|
CD1
|
F:ILE100
|
4.2
|
52.5
|
1.0
|
C17
|
A:R89301
|
4.3
|
68.5
|
1.0
|
C15
|
A:R89301
|
4.3
|
68.6
|
1.0
|
CZ
|
A:TYR118
|
4.3
|
56.6
|
1.0
|
CD1
|
A:TYR118
|
4.4
|
55.6
|
1.0
|
CB
|
A:TYR118
|
4.4
|
54.4
|
1.0
|
CB
|
F:ILE100
|
4.5
|
53.4
|
1.0
|
CD1
|
F:LEU104
|
4.5
|
51.1
|
1.0
|
CE1
|
A:TYR118
|
4.5
|
56.0
|
1.0
|
CG2
|
A:VAL148
|
4.6
|
69.7
|
1.0
|
CG1
|
F:ILE100
|
4.7
|
53.3
|
1.0
|
C16
|
A:R89301
|
4.8
|
67.7
|
1.0
|
OG1
|
F:THR135
|
4.9
|
44.8
|
1.0
|
CE
|
A:MET88
|
5.0
|
79.1
|
1.0
|
|
Chlorine binding site 2 out
of 7 in 8w7c
Go back to
Chlorine Binding Sites List in 8w7c
Chlorine binding site 2 out
of 7 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl301
b:62.2
occ:1.00
|
CL19
|
B:R89301
|
0.0
|
62.2
|
1.0
|
C13
|
B:R89301
|
1.8
|
60.5
|
1.0
|
C18
|
B:R89301
|
2.9
|
60.2
|
1.0
|
C14
|
B:R89301
|
2.9
|
61.5
|
1.0
|
CG1
|
B:VAL148
|
3.4
|
59.9
|
1.0
|
CD2
|
B:TYR118
|
3.7
|
52.0
|
1.0
|
CB
|
B:VAL148
|
3.8
|
60.2
|
1.0
|
CE2
|
B:TYR118
|
3.9
|
52.2
|
1.0
|
CE
|
B:MET88
|
4.1
|
82.7
|
1.0
|
C15
|
B:R89301
|
4.3
|
61.2
|
1.0
|
CG2
|
B:VAL148
|
4.3
|
61.4
|
1.0
|
C17
|
B:R89301
|
4.3
|
59.9
|
1.0
|
CG
|
B:TYR118
|
4.3
|
53.2
|
1.0
|
CZ
|
B:TYR118
|
4.6
|
52.5
|
1.0
|
C16
|
B:R89301
|
4.8
|
60.5
|
1.0
|
CB
|
B:TYR118
|
4.9
|
52.2
|
1.0
|
CD1
|
B:TYR118
|
4.9
|
52.6
|
1.0
|
|
Chlorine binding site 3 out
of 7 in 8w7c
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Chlorine Binding Sites List in 8w7c
Chlorine binding site 3 out
of 7 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Cl301
b:63.8
occ:1.00
|
CL19
|
C:R89301
|
0.0
|
63.8
|
1.0
|
C13
|
C:R89301
|
1.8
|
61.4
|
1.0
|
C14
|
C:R89301
|
2.8
|
61.4
|
1.0
|
C18
|
C:R89301
|
2.9
|
61.0
|
1.0
|
CG1
|
C:VAL148
|
3.4
|
67.7
|
1.0
|
CB
|
C:VAL148
|
3.6
|
68.8
|
1.0
|
CD2
|
C:TYR118
|
3.7
|
50.1
|
1.0
|
CE2
|
C:TYR118
|
3.9
|
50.6
|
1.0
|
CG
|
C:TYR118
|
3.9
|
51.6
|
1.0
|
CG2
|
D:ILE100
|
4.0
|
44.1
|
1.0
|
CG2
|
C:VAL148
|
4.1
|
70.1
|
1.0
|
C15
|
C:R89301
|
4.3
|
60.6
|
1.0
|
C17
|
C:R89301
|
4.3
|
60.8
|
1.0
|
CZ
|
C:TYR118
|
4.3
|
51.7
|
1.0
|
CD1
|
C:TYR118
|
4.3
|
51.4
|
1.0
|
CB
|
C:TYR118
|
4.5
|
50.7
|
1.0
|
CE1
|
C:TYR118
|
4.5
|
51.3
|
1.0
|
CD1
|
D:LEU104
|
4.7
|
49.0
|
1.0
|
C16
|
C:R89301
|
4.8
|
60.8
|
1.0
|
CD1
|
D:ILE100
|
5.0
|
45.6
|
1.0
|
|
Chlorine binding site 4 out
of 7 in 8w7c
Go back to
Chlorine Binding Sites List in 8w7c
Chlorine binding site 4 out
of 7 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Cl301
b:64.4
occ:1.00
|
CL19
|
D:R89301
|
0.0
|
64.4
|
1.0
|
C13
|
D:R89301
|
1.8
|
59.8
|
1.0
|
C18
|
D:R89301
|
2.9
|
60.1
|
1.0
|
C14
|
D:R89301
|
2.9
|
59.2
|
1.0
|
CG1
|
D:VAL148
|
3.4
|
67.3
|
1.0
|
CD2
|
D:TYR118
|
3.6
|
47.9
|
1.0
|
CG
|
D:TYR118
|
3.7
|
48.7
|
1.0
|
CB
|
D:VAL148
|
3.7
|
68.3
|
1.0
|
CE2
|
D:TYR118
|
4.0
|
47.0
|
1.0
|
CB
|
D:TYR118
|
4.1
|
49.2
|
1.0
|
CD1
|
D:TYR118
|
4.1
|
48.1
|
1.0
|
CG2
|
A:ILE100
|
4.2
|
42.4
|
1.0
|
CE
|
D:MET88
|
4.3
|
73.0
|
1.0
|
C17
|
D:R89301
|
4.3
|
60.1
|
1.0
|
C15
|
D:R89301
|
4.3
|
60.4
|
1.0
|
CG2
|
D:VAL148
|
4.3
|
69.3
|
1.0
|
CZ
|
D:TYR118
|
4.4
|
47.6
|
1.0
|
CE1
|
D:TYR118
|
4.5
|
48.2
|
1.0
|
C16
|
D:R89301
|
4.8
|
60.9
|
1.0
|
CD1
|
A:ILE100
|
4.8
|
42.5
|
1.0
|
CA
|
D:TYR118
|
5.0
|
48.2
|
1.0
|
CA
|
D:VAL148
|
5.0
|
68.3
|
1.0
|
|
Chlorine binding site 5 out
of 7 in 8w7c
Go back to
Chlorine Binding Sites List in 8w7c
Chlorine binding site 5 out
of 7 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Cl301
b:83.7
occ:1.00
|
CL19
|
E:R89301
|
0.0
|
83.7
|
1.0
|
C13
|
E:R89301
|
1.8
|
73.6
|
1.0
|
C14
|
E:R89301
|
2.9
|
73.7
|
1.0
|
C18
|
E:R89301
|
2.9
|
72.3
|
1.0
|
CA
|
C:THR135
|
3.3
|
45.0
|
1.0
|
CB
|
C:TYR138
|
3.4
|
62.6
|
1.0
|
CD1
|
E:LEU170
|
3.4
|
44.5
|
1.0
|
OG1
|
C:THR135
|
3.6
|
45.1
|
1.0
|
CG
|
C:TYR138
|
3.7
|
63.2
|
1.0
|
CG2
|
C:THR135
|
3.7
|
44.3
|
1.0
|
CB
|
C:THR135
|
3.7
|
44.6
|
1.0
|
O
|
C:ASP134
|
3.9
|
59.8
|
1.0
|
N
|
C:THR135
|
3.9
|
45.7
|
1.0
|
CD2
|
E:LEU170
|
4.0
|
44.9
|
1.0
|
CD1
|
C:TYR138
|
4.1
|
62.2
|
1.0
|
C
|
C:ASP134
|
4.2
|
59.8
|
1.0
|
C15
|
E:R89301
|
4.3
|
71.1
|
1.0
|
C17
|
E:R89301
|
4.3
|
73.0
|
1.0
|
CD2
|
C:TYR138
|
4.3
|
65.1
|
1.0
|
CG
|
E:LEU170
|
4.3
|
44.8
|
1.0
|
C
|
C:THR135
|
4.4
|
45.9
|
1.0
|
O
|
C:THR135
|
4.4
|
45.3
|
1.0
|
CD1
|
C:LEU104
|
4.8
|
49.8
|
1.0
|
C16
|
E:R89301
|
4.8
|
72.5
|
1.0
|
CA
|
C:TYR138
|
4.8
|
62.2
|
1.0
|
CE1
|
C:TYR138
|
5.0
|
62.6
|
1.0
|
|
Chlorine binding site 6 out
of 7 in 8w7c
Go back to
Chlorine Binding Sites List in 8w7c
Chlorine binding site 6 out
of 7 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:Cl301
b:68.1
occ:1.00
|
CL19
|
F:R89301
|
0.0
|
68.1
|
1.0
|
C13
|
F:R89301
|
1.8
|
64.6
|
1.0
|
C14
|
F:R89301
|
2.9
|
65.1
|
1.0
|
C18
|
F:R89301
|
2.9
|
64.8
|
1.0
|
CD2
|
F:TYR118
|
3.3
|
56.0
|
1.0
|
CG1
|
F:VAL148
|
3.4
|
62.8
|
1.0
|
CG
|
F:TYR118
|
3.4
|
56.7
|
1.0
|
CE2
|
F:TYR118
|
3.6
|
56.5
|
1.0
|
CD1
|
F:TYR118
|
3.8
|
55.6
|
1.0
|
CE
|
F:MET88
|
3.8
|
86.3
|
1.0
|
CB
|
F:TYR118
|
4.0
|
56.3
|
1.0
|
CZ
|
F:TYR118
|
4.0
|
56.6
|
1.0
|
CB
|
F:VAL148
|
4.0
|
64.1
|
1.0
|
CE1
|
F:TYR118
|
4.0
|
55.5
|
1.0
|
CG2
|
G:ILE100
|
4.2
|
51.1
|
1.0
|
C15
|
F:R89301
|
4.3
|
64.1
|
1.0
|
C17
|
F:R89301
|
4.3
|
65.8
|
1.0
|
CG2
|
F:VAL148
|
4.7
|
65.0
|
1.0
|
C16
|
F:R89301
|
4.8
|
65.0
|
1.0
|
OH
|
F:TYR118
|
4.9
|
56.7
|
1.0
|
CA
|
F:TYR118
|
4.9
|
55.7
|
1.0
|
CD1
|
G:LEU104
|
5.0
|
58.1
|
1.0
|
|
Chlorine binding site 7 out
of 7 in 8w7c
Go back to
Chlorine Binding Sites List in 8w7c
Chlorine binding site 7 out
of 7 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 7 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
G:Cl301
b:76.0
occ:1.00
|
CL19
|
G:R89301
|
0.0
|
76.0
|
1.0
|
C13
|
G:R89301
|
1.8
|
72.3
|
1.0
|
C14
|
G:R89301
|
2.9
|
71.1
|
1.0
|
C18
|
G:R89301
|
2.9
|
73.2
|
1.0
|
CG1
|
G:VAL148
|
3.4
|
79.3
|
1.0
|
CD2
|
G:TYR118
|
3.5
|
49.9
|
1.0
|
CE2
|
G:TYR118
|
3.6
|
50.8
|
1.0
|
CG2
|
G:VAL148
|
3.6
|
77.1
|
1.0
|
CG
|
G:TYR118
|
3.8
|
50.8
|
1.0
|
CZ
|
G:TYR118
|
4.0
|
51.7
|
1.0
|
CB
|
G:VAL148
|
4.1
|
77.5
|
1.0
|
CD1
|
G:TYR118
|
4.1
|
52.2
|
1.0
|
CE
|
G:MET88
|
4.2
|
86.3
|
1.0
|
CE1
|
G:TYR118
|
4.2
|
52.3
|
1.0
|
C15
|
G:R89301
|
4.3
|
71.5
|
1.0
|
C17
|
G:R89301
|
4.3
|
73.3
|
1.0
|
CB
|
G:TYR118
|
4.5
|
50.4
|
1.0
|
OH
|
G:TYR118
|
4.7
|
50.6
|
1.0
|
C16
|
G:R89301
|
4.8
|
73.5
|
1.0
|
|
Reference:
J.-X.Jiang,
H.Ding,
M.-L.Lu,
M.-R.Chen,
H.-Y.Sun,
Y.-B.Xiao.
Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality To Be Published.
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