Chlorine in PDB 8w7c: Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality

Enzymatic activity of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality

All present enzymatic activity of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality:
3.4.21.92;

Protein crystallography data

The structure of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality, PDB code: 8w7c was solved by J.-X.Jiang, H.Ding, M.-L.Lu, M.-R.Chen, H.-Y.Sun, Y.-B.Xiao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.20 / 3.00
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 142.245, 153.591, 104.617, 90, 117.96, 90
R / Rfree (%) 24 / 26

Other elements in 8w7c:

The structure of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality also contains other interesting chemical elements:

Fluorine (F) 21 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality (pdb code 8w7c). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 7 binding sites of Chlorine where determined in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality, PDB code: 8w7c:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7;

Chlorine binding site 1 out of 7 in 8w7c

Go back to Chlorine Binding Sites List in 8w7c
Chlorine binding site 1 out of 7 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl301

b:72.7
occ:1.00
CL19 A:R89301 0.0 72.7 1.0
C13 A:R89301 1.8 66.5 1.0
C18 A:R89301 2.9 66.6 1.0
C14 A:R89301 2.9 69.2 1.0
CG2 F:ILE100 3.3 52.4 1.0
CG1 A:VAL148 3.5 65.6 1.0
CD2 A:TYR118 3.6 55.7 1.0
CE2 A:TYR118 3.8 56.0 1.0
CG A:TYR118 3.9 56.3 1.0
CB A:VAL148 4.1 67.5 1.0
CD1 F:ILE100 4.2 52.5 1.0
C17 A:R89301 4.3 68.5 1.0
C15 A:R89301 4.3 68.6 1.0
CZ A:TYR118 4.3 56.6 1.0
CD1 A:TYR118 4.4 55.6 1.0
CB A:TYR118 4.4 54.4 1.0
CB F:ILE100 4.5 53.4 1.0
CD1 F:LEU104 4.5 51.1 1.0
CE1 A:TYR118 4.5 56.0 1.0
CG2 A:VAL148 4.6 69.7 1.0
CG1 F:ILE100 4.7 53.3 1.0
C16 A:R89301 4.8 67.7 1.0
OG1 F:THR135 4.9 44.8 1.0
CE A:MET88 5.0 79.1 1.0

Chlorine binding site 2 out of 7 in 8w7c

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Chlorine binding site 2 out of 7 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl301

b:62.2
occ:1.00
CL19 B:R89301 0.0 62.2 1.0
C13 B:R89301 1.8 60.5 1.0
C18 B:R89301 2.9 60.2 1.0
C14 B:R89301 2.9 61.5 1.0
CG1 B:VAL148 3.4 59.9 1.0
CD2 B:TYR118 3.7 52.0 1.0
CB B:VAL148 3.8 60.2 1.0
CE2 B:TYR118 3.9 52.2 1.0
CE B:MET88 4.1 82.7 1.0
C15 B:R89301 4.3 61.2 1.0
CG2 B:VAL148 4.3 61.4 1.0
C17 B:R89301 4.3 59.9 1.0
CG B:TYR118 4.3 53.2 1.0
CZ B:TYR118 4.6 52.5 1.0
C16 B:R89301 4.8 60.5 1.0
CB B:TYR118 4.9 52.2 1.0
CD1 B:TYR118 4.9 52.6 1.0

Chlorine binding site 3 out of 7 in 8w7c

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Chlorine binding site 3 out of 7 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl301

b:63.8
occ:1.00
CL19 C:R89301 0.0 63.8 1.0
C13 C:R89301 1.8 61.4 1.0
C14 C:R89301 2.8 61.4 1.0
C18 C:R89301 2.9 61.0 1.0
CG1 C:VAL148 3.4 67.7 1.0
CB C:VAL148 3.6 68.8 1.0
CD2 C:TYR118 3.7 50.1 1.0
CE2 C:TYR118 3.9 50.6 1.0
CG C:TYR118 3.9 51.6 1.0
CG2 D:ILE100 4.0 44.1 1.0
CG2 C:VAL148 4.1 70.1 1.0
C15 C:R89301 4.3 60.6 1.0
C17 C:R89301 4.3 60.8 1.0
CZ C:TYR118 4.3 51.7 1.0
CD1 C:TYR118 4.3 51.4 1.0
CB C:TYR118 4.5 50.7 1.0
CE1 C:TYR118 4.5 51.3 1.0
CD1 D:LEU104 4.7 49.0 1.0
C16 C:R89301 4.8 60.8 1.0
CD1 D:ILE100 5.0 45.6 1.0

Chlorine binding site 4 out of 7 in 8w7c

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Chlorine binding site 4 out of 7 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl301

b:64.4
occ:1.00
CL19 D:R89301 0.0 64.4 1.0
C13 D:R89301 1.8 59.8 1.0
C18 D:R89301 2.9 60.1 1.0
C14 D:R89301 2.9 59.2 1.0
CG1 D:VAL148 3.4 67.3 1.0
CD2 D:TYR118 3.6 47.9 1.0
CG D:TYR118 3.7 48.7 1.0
CB D:VAL148 3.7 68.3 1.0
CE2 D:TYR118 4.0 47.0 1.0
CB D:TYR118 4.1 49.2 1.0
CD1 D:TYR118 4.1 48.1 1.0
CG2 A:ILE100 4.2 42.4 1.0
CE D:MET88 4.3 73.0 1.0
C17 D:R89301 4.3 60.1 1.0
C15 D:R89301 4.3 60.4 1.0
CG2 D:VAL148 4.3 69.3 1.0
CZ D:TYR118 4.4 47.6 1.0
CE1 D:TYR118 4.5 48.2 1.0
C16 D:R89301 4.8 60.9 1.0
CD1 A:ILE100 4.8 42.5 1.0
CA D:TYR118 5.0 48.2 1.0
CA D:VAL148 5.0 68.3 1.0

Chlorine binding site 5 out of 7 in 8w7c

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Chlorine binding site 5 out of 7 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl301

b:83.7
occ:1.00
CL19 E:R89301 0.0 83.7 1.0
C13 E:R89301 1.8 73.6 1.0
C14 E:R89301 2.9 73.7 1.0
C18 E:R89301 2.9 72.3 1.0
CA C:THR135 3.3 45.0 1.0
CB C:TYR138 3.4 62.6 1.0
CD1 E:LEU170 3.4 44.5 1.0
OG1 C:THR135 3.6 45.1 1.0
CG C:TYR138 3.7 63.2 1.0
CG2 C:THR135 3.7 44.3 1.0
CB C:THR135 3.7 44.6 1.0
O C:ASP134 3.9 59.8 1.0
N C:THR135 3.9 45.7 1.0
CD2 E:LEU170 4.0 44.9 1.0
CD1 C:TYR138 4.1 62.2 1.0
C C:ASP134 4.2 59.8 1.0
C15 E:R89301 4.3 71.1 1.0
C17 E:R89301 4.3 73.0 1.0
CD2 C:TYR138 4.3 65.1 1.0
CG E:LEU170 4.3 44.8 1.0
C C:THR135 4.4 45.9 1.0
O C:THR135 4.4 45.3 1.0
CD1 C:LEU104 4.8 49.8 1.0
C16 E:R89301 4.8 72.5 1.0
CA C:TYR138 4.8 62.2 1.0
CE1 C:TYR138 5.0 62.6 1.0

Chlorine binding site 6 out of 7 in 8w7c

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Chlorine binding site 6 out of 7 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl301

b:68.1
occ:1.00
CL19 F:R89301 0.0 68.1 1.0
C13 F:R89301 1.8 64.6 1.0
C14 F:R89301 2.9 65.1 1.0
C18 F:R89301 2.9 64.8 1.0
CD2 F:TYR118 3.3 56.0 1.0
CG1 F:VAL148 3.4 62.8 1.0
CG F:TYR118 3.4 56.7 1.0
CE2 F:TYR118 3.6 56.5 1.0
CD1 F:TYR118 3.8 55.6 1.0
CE F:MET88 3.8 86.3 1.0
CB F:TYR118 4.0 56.3 1.0
CZ F:TYR118 4.0 56.6 1.0
CB F:VAL148 4.0 64.1 1.0
CE1 F:TYR118 4.0 55.5 1.0
CG2 G:ILE100 4.2 51.1 1.0
C15 F:R89301 4.3 64.1 1.0
C17 F:R89301 4.3 65.8 1.0
CG2 F:VAL148 4.7 65.0 1.0
C16 F:R89301 4.8 65.0 1.0
OH F:TYR118 4.9 56.7 1.0
CA F:TYR118 4.9 55.7 1.0
CD1 G:LEU104 5.0 58.1 1.0

Chlorine binding site 7 out of 7 in 8w7c

Go back to Chlorine Binding Sites List in 8w7c
Chlorine binding site 7 out of 7 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Cl301

b:76.0
occ:1.00
CL19 G:R89301 0.0 76.0 1.0
C13 G:R89301 1.8 72.3 1.0
C14 G:R89301 2.9 71.1 1.0
C18 G:R89301 2.9 73.2 1.0
CG1 G:VAL148 3.4 79.3 1.0
CD2 G:TYR118 3.5 49.9 1.0
CE2 G:TYR118 3.6 50.8 1.0
CG2 G:VAL148 3.6 77.1 1.0
CG G:TYR118 3.8 50.8 1.0
CZ G:TYR118 4.0 51.7 1.0
CB G:VAL148 4.1 77.5 1.0
CD1 G:TYR118 4.1 52.2 1.0
CE G:MET88 4.2 86.3 1.0
CE1 G:TYR118 4.2 52.3 1.0
C15 G:R89301 4.3 71.5 1.0
C17 G:R89301 4.3 73.3 1.0
CB G:TYR118 4.5 50.4 1.0
OH G:TYR118 4.7 50.6 1.0
C16 G:R89301 4.8 73.5 1.0

Reference:

J.-X.Jiang, H.Ding, M.-L.Lu, M.-R.Chen, H.-Y.Sun, Y.-B.Xiao. Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality To Be Published.
Page generated: Sat Sep 28 19:37:58 2024

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