Chlorine in PDB 8wcr: Cryo-Em Structure of Nanodisc (Pe:Ps:Pc) Reconstituted Glic at pH 4 in Open State

The binding sites of Chlorine atom in the Cryo-Em Structure of Nanodisc (Pe:Ps:Pc) Reconstituted Glic at pH 4 in Open State (pdb code 8wcr). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Cryo-Em Structure of Nanodisc (Pe:Ps:Pc) Reconstituted Glic at pH 4 in Open State, PDB code: 8wcr:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the Cryo-Em Structure of Nanodisc (Pe:Ps:Pc) Reconstituted Glic at pH 4 in Open State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Nanodisc (Pe:Ps:Pc) Reconstituted Glic at pH 4 in Open State within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl401 b:53.7 occ:1.00 NH1 E:ARG85 3.4 53.4 1.0 N E:PHE78 3.5 38.3 1.0 O D:HOH517 3.5 53.4 1.0 N E:ARG85 3.8 63.7 1.0 CD2 E:PHE78 4.0 41.1 1.0 CA E:ARG77 4.0 44.0 1.0 CG E:ARG85 4.0 47.9 1.0 CA E:ALA84 4.1 56.6 1.0 CB E:PHE78 4.2 37.0 1.0 CD E:ARG85 4.2 52.4 1.0 C E:ARG77 4.3 41.2 1.0 CG E:ARG77 4.3 48.6 1.0 CB E:ARG85 4.3 53.4 1.0 CA E:PHE78 4.4 36.9 1.0 CB E:ARG77 4.4 43.4 1.0 CB E:ALA84 4.4 56.1 1.0 O E:PHE78 4.5 52.3 1.0 C E:ALA84 4.5 66.6 1.0 CZ E:ARG85 4.5 57.8 1.0 CG E:PHE78 4.6 42.4 1.0 CG2 E:VAL81 4.6 39.0 1.0 CA E:ARG85 4.7 55.4 1.0 NE E:ARG85 4.8 58.1 1.0 O E:ILE76 4.8 56.0 1.0 C E:PHE78 4.9 42.3 1.0

Chlorine binding site 2 out of 5 in the Cryo-Em Structure of Nanodisc (Pe:Ps:Pc) Reconstituted Glic at pH 4 in Open State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of Nanodisc (Pe:Ps:Pc) Reconstituted Glic at pH 4 in Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl402 b:53.7 occ:1.00 NH1 A:ARG85 3.4 53.4 1.0 N A:PHE78 3.5 38.3 1.0 O E:HOH517 3.5 53.4 1.0 N A:ARG85 3.8 63.7 1.0 CD2 A:PHE78 4.0 41.1 1.0 CA A:ARG77 4.0 44.0 1.0 CG A:ARG85 4.0 47.9 1.0 CA A:ALA84 4.1 56.6 1.0 CB A:PHE78 4.2 37.0 1.0 CD A:ARG85 4.2 52.4 1.0 C A:ARG77 4.3 41.2 1.0 CB A:ARG85 4.3 53.4 1.0 CG A:ARG77 4.3 48.6 1.0 CA A:PHE78 4.4 36.9 1.0 CB A:ARG77 4.4 43.4 1.0 CB A:ALA84 4.4 56.1 1.0 O A:PHE78 4.5 52.3 1.0 C A:ALA84 4.5 66.6 1.0 CZ A:ARG85 4.5 57.8 1.0 CG A:PHE78 4.6 42.4 1.0 CG2 A:VAL81 4.6 39.0 1.0 CA A:ARG85 4.7 55.4 1.0 NE A:ARG85 4.8 58.1 1.0 O A:ILE76 4.8 56.0 1.0 C A:PHE78 4.9 42.3 1.0

Chlorine binding site 3 out of 5 in the Cryo-Em Structure of Nanodisc (Pe:Ps:Pc) Reconstituted Glic at pH 4 in Open State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cryo-Em Structure of Nanodisc (Pe:Ps:Pc) Reconstituted Glic at pH 4 in Open State within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl402 b:53.7 occ:1.00 NH1 B:ARG85 3.4 53.4 1.0 N B:PHE78 3.5 38.3 1.0 O A:HOH517 3.5 53.4 1.0 N B:ARG85 3.8 63.7 1.0 CD2 B:PHE78 4.0 41.1 1.0 CA B:ARG77 4.0 44.0 1.0 CG B:ARG85 4.0 47.9 1.0 CA B:ALA84 4.1 56.6 1.0 CB B:PHE78 4.2 37.0 1.0 CD B:ARG85 4.2 52.4 1.0 C B:ARG77 4.3 41.2 1.0 CG B:ARG77 4.3 48.6 1.0 CB B:ARG85 4.3 53.4 1.0 CA B:PHE78 4.4 36.9 1.0 CB B:ARG77 4.4 43.4 1.0 CB B:ALA84 4.4 56.1 1.0 O B:PHE78 4.5 52.3 1.0 C B:ALA84 4.5 66.6 1.0 CZ B:ARG85 4.5 57.8 1.0 CG B:PHE78 4.6 42.4 1.0 CG2 B:VAL81 4.6 39.0 1.0 CA B:ARG85 4.7 55.4 1.0 NE B:ARG85 4.8 58.1 1.0 O B:ILE76 4.8 56.0 1.0 C B:PHE78 4.9 42.3 1.0

Chlorine binding site 4 out of 5 in the Cryo-Em Structure of Nanodisc (Pe:Ps:Pc) Reconstituted Glic at pH 4 in Open State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Cryo-Em Structure of Nanodisc (Pe:Ps:Pc) Reconstituted Glic at pH 4 in Open State within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl402 b:53.7 occ:1.00 NH1 C:ARG85 3.4 53.4 1.0 N C:PHE78 3.5 38.3 1.0 O B:HOH517 3.5 53.4 1.0 N C:ARG85 3.8 63.7 1.0 CD2 C:PHE78 4.0 41.1 1.0 CA C:ARG77 4.0 44.0 1.0 CG C:ARG85 4.0 47.9 1.0 CA C:ALA84 4.1 56.6 1.0 CB C:PHE78 4.2 37.0 1.0 CD C:ARG85 4.2 52.4 1.0 C C:ARG77 4.3 41.2 1.0 CG C:ARG77 4.3 48.6 1.0 CB C:ARG85 4.3 53.4 1.0 CA C:PHE78 4.4 36.9 1.0 CB C:ARG77 4.4 43.4 1.0 CB C:ALA84 4.4 56.1 1.0 O C:PHE78 4.5 52.3 1.0 C C:ALA84 4.5 66.6 1.0 CZ C:ARG85 4.5 57.8 1.0 CG C:PHE78 4.6 42.4 1.0 CG2 C:VAL81 4.6 39.0 1.0 CA C:ARG85 4.7 55.4 1.0 NE C:ARG85 4.8 58.1 1.0 O C:ILE76 4.8 56.0 1.0 C C:PHE78 4.9 42.3 1.0

Chlorine binding site 5 out of 5 in the Cryo-Em Structure of Nanodisc (Pe:Ps:Pc) Reconstituted Glic at pH 4 in Open State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Cryo-Em Structure of Nanodisc (Pe:Ps:Pc) Reconstituted Glic at pH 4 in Open State within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl402 b:53.7 occ:1.00 NH1 D:ARG85 3.4 53.4 1.0 N D:PHE78 3.5 38.3 1.0 O C:HOH517 3.5 53.4 1.0 N D:ARG85 3.8 63.7 1.0 CD2 D:PHE78 4.0 41.1 1.0 CA D:ARG77 4.0 44.0 1.0 CG D:ARG85 4.0 47.9 1.0 CA D:ALA84 4.1 56.6 1.0 CB D:PHE78 4.2 37.0 1.0 CD D:ARG85 4.2 52.4 1.0 C D:ARG77 4.3 41.2 1.0 CG D:ARG77 4.3 48.6 1.0 CB D:ARG85 4.3 53.4 1.0 CA D:PHE78 4.4 36.9 1.0 CB D:ARG77 4.4 43.4 1.0 CB D:ALA84 4.4 56.1 1.0 O D:PHE78 4.5 52.3 1.0 C D:ALA84 4.5 66.6 1.0 CZ D:ARG85 4.5 57.8 1.0 CG D:PHE78 4.6 42.4 1.0 CG2 D:VAL81 4.6 39.0 1.0 CA D:ARG85 4.7 55.4 1.0 NE D:ARG85 4.8 58.1 1.0 O D:ILE76 4.8 56.0 1.0 C D:PHE78 4.9 42.3 1.0

N.Bharambe, Z.Li, D.Seiferth, A.M.Balakrishna, P.C.Biggin, S.Basak. Cryo-Em Structures of Prokaryotic Ligand-Gated Ion Channel Glic Provide Insights Into Gating in A Lipid Environment. Nat Commun V. 15 2967 2024.
ISSN: ESSN 2041-1723
PubMed: 38580666
DOI: 10.1038/S41467-024-47370-W