Chlorine in PDB 8wfk: Human Glycine Transporter 1 in Complex with SSR504734 in Outward Facing Conformation

The structure of Human Glycine Transporter 1 in Complex with SSR504734 in Outward Facing Conformation also contains other interesting chemical elements:

Sodium	(Na)	2 atoms
Fluorine	(F)	3 atoms

The binding sites of Chlorine atom in the Human Glycine Transporter 1 in Complex with SSR504734 in Outward Facing Conformation (pdb code 8wfk). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human Glycine Transporter 1 in Complex with SSR504734 in Outward Facing Conformation, PDB code: 8wfk:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Human Glycine Transporter 1 in Complex with SSR504734 in Outward Facing Conformation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Glycine Transporter 1 in Complex with SSR504734 in Outward Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl701 b:97.0 occ:1.00 CL27 A:W5O701 0.0 97.0 1.0 C18 A:W5O701 1.8 75.1 1.0 F25 A:W5O701 2.7 76.5 1.0 C19 A:W5O701 2.8 66.9 1.0 C17 A:W5O701 2.8 72.4 1.0 C23 A:W5O701 3.0 68.9 1.0 C15 A:W5O701 3.1 73.8 1.0 F26 A:W5O701 3.2 68.9 1.0 O16 A:W5O701 3.3 75.2 1.0 N14 A:W5O701 3.9 76.1 1.0 CE1 A:TYR141 4.0 71.6 1.0 C20 A:W5O701 4.0 67.1 1.0 OD1 A:ASP474 4.0 82.9 1.0 C22 A:W5O701 4.0 75.5 1.0 CG A:ASP474 4.2 81.8 1.0 OD2 A:ASP474 4.3 92.0 1.0 F24 A:W5O701 4.4 76.5 1.0 CZ2 A:TRP70 4.4 64.6 1.0 C21 A:W5O701 4.6 76.9 1.0 OH A:TYR141 4.6 75.8 1.0 CE1 A:TYR142 4.8 71.3 1.0 CZ A:TYR141 4.8 73.5 1.0 CB A:ASP474 4.8 71.5 1.0 C07 A:W5O701 4.9 74.5 1.0 CD1 A:TYR141 4.9 68.8 1.0 C13 A:W5O701 4.9 76.3 1.0 CG2 A:VAL145 5.0 55.1 1.0 CH2 A:TRP70 5.0 61.6 1.0

Chlorine binding site 2 out of 2 in the Human Glycine Transporter 1 in Complex with SSR504734 in Outward Facing Conformation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Glycine Transporter 1 in Complex with SSR504734 in Outward Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl702 b:30.0 occ:1.00 NE2 A:GLN313 2.5 65.8 1.0 OH A:TYR88 3.0 76.8 1.0 OG A:SER317 3.1 62.8 1.0 CB A:SER317 3.4 56.7 1.0 OG A:SER353 3.6 62.8 1.0 CD A:GLN313 3.6 69.6 1.0 CG A:GLN313 3.9 65.1 1.0 ND2 A:ASN68 4.0 68.9 1.0 CZ A:TYR88 4.2 71.1 1.0 O A:GLY67 4.5 73.5 1.0 CB A:SER353 4.5 57.0 1.0 CD1 A:PHE72 4.6 61.9 1.0 O A:GLN313 4.6 68.6 1.0 CG A:ASN68 4.6 73.9 1.0 CE1 A:TYR88 4.6 68.7 1.0 OE1 A:GLN313 4.7 65.3 1.0 CB A:PHE72 4.7 65.1 1.0 CA A:ASN68 4.8 63.1 1.0 CA A:SER317 4.9 57.5 1.0 CG A:PHE72 4.9 61.9 1.0 CB A:ASN68 4.9 68.5 1.0

Y.Wei, R.Li, Y.Meng, T.Hu, J.Zhao, Y.Gao, Q.Bai, N.Li, Y.Zhao. Transport Mechanism and Pharmacology of the Human GLYT1. Cell 2024.
ISSN: ISSN 1097-4172
PubMed: 38513663
DOI: 10.1016/J.CELL.2024.02.026