Chlorine in PDB 8zvy: Alpha-Synuclein with H2A-H2B Dimer Complex Structure.

The structure of Alpha-Synuclein with H2A-H2B Dimer Complex Structure., PDB code: 8zvy was solved by S.Padavattan, S.Jos, A.Kambaru, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.48 / 1.72
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	61.005, 68.24, 102.576, 90, 90, 90
R / Rfree (%)	19.1 / 22

The binding sites of Chlorine atom in the Alpha-Synuclein with H2A-H2B Dimer Complex Structure. (pdb code 8zvy). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Alpha-Synuclein with H2A-H2B Dimer Complex Structure., PDB code: 8zvy:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Alpha-Synuclein with H2A-H2B Dimer Complex Structure.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Alpha-Synuclein with H2A-H2B Dimer Complex Structure. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1201 b:59.1 occ:1.00 N A:GLY1047 2.9 36.2 1.0 C A:GLY1045 3.3 39.9 1.0 CA A:GLY1045 3.3 37.2 1.0 N A:ALA1046 3.4 40.5 1.0 CA A:GLY1047 3.5 36.1 1.0 CB A:THR91 3.6 34.5 1.0 O A:GLY1045 3.8 37.2 1.0 CG2 A:THR91 3.8 39.0 1.0 CA A:THR91 3.8 32.8 1.0 N A:ALA1048 4.0 32.3 1.0 C A:ALA1046 4.0 41.0 1.0 C A:GLY1047 4.2 33.4 1.0 CA A:ALA1046 4.2 41.0 1.0 N A:SER92 4.3 30.2 1.0 N A:GLY1045 4.4 35.0 1.0 O A:HOH1367 4.6 52.9 1.0 C A:THR91 4.6 32.8 1.0 O A:ILE90 4.7 33.5 1.0 OG1 A:THR91 4.9 36.5 1.0 N A:THR91 5.0 29.6 1.0

Chlorine binding site 2 out of 2 in the Alpha-Synuclein with H2A-H2B Dimer Complex Structure.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Alpha-Synuclein with H2A-H2B Dimer Complex Structure. within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1201 b:34.3 occ:1.00 N B:GLY1047 3.2 33.6 1.0 N B:SER92 3.3 28.7 1.0 O B:HOH1345 3.3 45.9 1.0 CA B:THR91 3.5 25.9 1.0 CB B:THR91 3.5 32.3 1.0 N B:ALA1048 3.6 27.9 1.0 CA B:GLY1047 3.6 33.5 1.0 C B:GLY1045 3.7 33.8 1.0 CA B:GLY1045 3.7 36.2 1.0 N B:ALA1046 3.8 35.5 1.0 OG B:SER92 3.8 31.6 0.4 C B:THR91 3.9 28.4 1.0 C B:GLY1047 4.0 32.5 1.0 O B:GLY1045 4.1 37.1 1.0 CG2 B:THR91 4.2 35.0 1.0 OG B:SER92 4.3 33.8 0.6 C B:ALA1046 4.3 38.3 1.0 CB B:SER92 4.4 31.5 0.4 CA B:SER92 4.4 27.9 0.4 CA B:SER92 4.4 28.2 0.6 CB B:SER92 4.4 31.6 0.6 CA B:ALA1048 4.6 26.1 1.0 CB B:ALA1048 4.6 26.9 1.0 N B:GLY1045 4.6 31.7 1.0 O B:ILE90 4.6 35.0 1.0 O B:HOH1364 4.6 50.6 1.0 CA B:ALA1046 4.7 39.9 1.0 OG1 B:THR91 4.7 35.5 1.0 N B:THR91 4.8 29.8 1.0

S.Jos, A.Kambaru, T.K.Prasad, S.Parthasarathi, N.Kamariah, S.Nath, B.Padmanabhan, S.Padavattan. Structural and Functional Insights Into the Nuclear Role of Parkinson'S Disease-Associated Alpha-Synuclein As A Histone Chaperone. Commun Biol V. 8 712 2025.
ISSN: ESSN 2399-3642
PubMed: 40341765
DOI: 10.1038/S42003-025-08138-0