Chlorine in PDB 9avb: FIS1 Wild Type

The structure of FIS1 Wild Type, PDB code: 9avb was solved by I.I.Mathews, S.Pokhrel, S.Wakatsuki, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.91 / 1.95
Space group	P 65
Cell size a, b, c (Å), α, β, γ (°)	58.33, 58.33, 156.29, 90, 90, 120
R / Rfree (%)	18.5 / 23.1

The binding sites of Chlorine atom in the FIS1 Wild Type (pdb code 9avb). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the FIS1 Wild Type, PDB code: 9avb:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the FIS1 Wild Type


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of FIS1 Wild Type within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl201 b:41.7 occ:1.00 O A:HOH358 2.5 36.2 1.0 N A:ASN104 3.6 31.4 1.0 C A:GLN103 3.7 28.8 1.0 CB A:GLN103 3.9 33.1 1.0 CA A:ASN104 4.0 31.8 1.0 CB A:ASN104 4.1 29.4 1.0 CA A:GLN103 4.1 30.8 1.0 O A:GLN103 4.1 30.9 1.0 CB A:GLU101 4.1 36.5 1.0 N A:GLN103 4.2 28.9 1.0 CA A:GLU101 4.5 32.9 1.0 C A:GLU101 4.5 32.0 1.0 O A:GLU101 4.5 29.9 1.0 CG A:GLU101 4.7 41.4 1.0 OE1 A:GLU101 4.8 35.7 1.0 CD A:GLU101 4.9 45.3 1.0

Chlorine binding site 2 out of 2 in the FIS1 Wild Type


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of FIS1 Wild Type within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl202 b:73.5 occ:1.00 O A:HOH301 3.4 47.3 0.5 CG A:LYS53 3.8 48.6 1.0 CG1 A:VAL56 3.9 31.4 1.0 O A:HOH301 4.1 47.6 0.5 CD A:LYS53 4.4 41.9 1.0 CB A:VAL56 4.5 30.4 1.0 O A:HOH371 4.5 57.8 1.0 O A:HOH302 4.6 66.5 1.0 CD2 A:LEU57 4.6 43.1 1.0 CB A:LYS53 4.7 34.9 1.0 CE A:LYS53 4.7 53.2 1.0 O A:LYS53 4.8 32.4 1.0 CA A:LYS53 4.8 32.1 1.0 CG A:LEU57 5.0 37.0 1.0

S.Pokhrel, G.Heo, I.Mathews, S.Yokoi, T.Matsui, A.Mitsutake, S.Wakatsuki, D.Mochly-Rosen. A Hidden Cysteine in FIS1 Targeted to Prevent Excessive Mitochondrial Fission and Dysfunction Under Oxidative Stress. Nat Commun V. 16 4187 2025.
ISSN: ESSN 2041-1723
PubMed: 40328741
DOI: 10.1038/S41467-025-59434-6