Chlorine in PDB 9cp5: Cryo-Em Structure of Human GAT3, Apo State, Inward-Open Conformation

The binding sites of Chlorine atom in the Cryo-Em Structure of Human GAT3, Apo State, Inward-Open Conformation (pdb code 9cp5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Cryo-Em Structure of Human GAT3, Apo State, Inward-Open Conformation, PDB code: 9cp5:

Chlorine binding site 1 out of 1 in the Cryo-Em Structure of Human GAT3, Apo State, Inward-Open Conformation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Human GAT3, Apo State, Inward-Open Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl800 b:86.2 occ:1.00 OG A:SER345 2.5 78.0 1.0 OH A:TYR92 2.7 71.0 1.0 OG A:SER309 2.9 81.2 1.0 CB A:SER309 3.1 81.2 1.0 NE2 A:GLN305 3.2 72.5 1.0 CB A:SER345 3.2 78.0 1.0 OD1 A:ASN72 3.6 77.4 1.0 CZ A:TYR92 3.9 71.0 1.0 O A:GLY71 4.2 76.5 1.0 CD A:GLN305 4.3 72.5 1.0 CE1 A:TYR92 4.3 71.0 1.0 O A:ASN341 4.4 87.4 1.0 CG A:GLN305 4.5 72.5 1.0 CB A:PHE76 4.5 67.3 1.0 O A:GLN305 4.5 72.5 1.0 CD1 A:PHE76 4.6 67.3 1.0 CA A:SER309 4.7 81.2 1.0 CG A:ASN72 4.7 77.4 1.0 CA A:SER345 4.7 78.0 1.0 CG A:PHE76 4.7 67.3 1.0 CA A:ASN72 4.9 77.4 1.0 C A:GLY71 4.9 76.5 1.0 CE1 A:TYR310 5.0 88.9 1.0

R.Yadav, G.W.Han, C.Gati. Molecular Basis of Human Gaba Transporter 3 Inhibition. Nat Commun V. 16 3830 2025.
ISSN: ESSN 2041-1723
PubMed: 40268946
DOI: 10.1038/S41467-025-59066-W