Chlorine in PDB 9do0: Human Clc-3

The binding sites of Chlorine atom in the Human Clc-3 (pdb code 9do0). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Human Clc-3, PDB code: 9do0:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Human Clc-3


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Clc-3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl901 b:18.9 occ:1.00 H A:ILE528 2.5 24.9 1.0 H A:GLY283 2.6 26.6 1.0 H A:GLU282 2.7 27.3 1.0 HB2 A:PHE527 2.7 27.4 1.0 HA3 A:GLY280 2.8 21.4 1.0 HA3 A:GLY525 2.8 21.3 1.0 HG12 A:ILE528 2.8 27.1 1.0 H A:PHE527 2.9 24.6 1.0 HB2 A:GLU282 3.0 27.2 1.0 N A:ILE528 3.4 17.9 1.0 N A:PHE527 3.4 14.7 1.0 CA A:GLY280 3.5 14.3 1.0 N A:GLY283 3.5 24.3 1.0 N A:GLU282 3.5 18.4 1.0 HB A:ILE528 3.5 26.2 1.0 C A:GLY280 3.5 22.1 1.0 CG1 A:ILE528 3.6 29.3 1.0 CA A:GLY525 3.6 15.2 1.0 C A:GLY525 3.6 18.2 1.0 CB A:PHE527 3.6 24.2 1.0 HD3 A:PRO284 3.6 25.7 1.0 HG13 A:ILE528 3.6 26.4 1.0 H A:GLY280 3.7 23.6 1.0 HD2 A:PRO284 3.8 25.5 1.0 CB A:GLU282 3.9 24.2 1.0 N A:LYS281 3.9 29.8 1.0 N A:LEU526 3.9 15.6 1.0 O A:GLY280 3.9 19.7 1.0 CA A:PHE527 3.9 22.1 1.0 CB A:ILE528 3.9 27.3 1.0 H A:LEU526 4.0 22.6 1.0 H A:LYS281 4.0 27.9 1.0 HD2 A:PHE527 4.0 26.3 1.0 O A:GLY525 4.0 26.9 1.0 N A:GLY280 4.0 23.0 1.0 HB3 A:PHE527 4.0 26.0 1.0 CA A:GLU282 4.1 23.4 1.0 HA3 A:GLY283 4.1 24.7 1.0 HA2 A:GLY525 4.1 22.6 1.0 HD3 A:PRO529 4.1 21.1 1.0 C A:PHE527 4.1 23.3 1.0 CD A:PRO284 4.2 25.1 1.0 HB3 A:GLU282 4.2 28.1 1.0 OE1 A:GLU282 4.2 33.5 1.0 CA A:ILE528 4.3 21.4 1.0 HA2 A:GLY280 4.3 21.8 1.0 C A:GLU282 4.3 22.7 1.0 HD2 A:PRO529 4.3 23.6 1.0 CA A:GLY283 4.4 19.6 1.0 C A:LEU526 4.4 19.4 1.0 H A:GLY525 4.5 24.0 1.0 C A:LYS281 4.5 24.0 1.0 N A:GLY525 4.6 26.2 1.0 CD A:PRO529 4.6 18.9 1.0 CG A:PHE527 4.7 33.0 1.0 CA A:LYS281 4.7 24.6 1.0 CD2 A:PHE527 4.7 25.0 1.0 CA A:LEU526 4.7 18.3 1.0 HA A:LYS281 4.8 28.5 1.0 HA A:ILE528 4.8 25.2 1.0 CD1 A:ILE528 4.8 21.7 1.0 HA A:PHE527 4.8 26.7 1.0 HD11 A:ILE528 4.9 26.5 1.0 CL A:CL902 5.0 33.2 1.0 HA2 A:GLY283 5.0 25.4 1.0 HA A:GLU282 5.0 28.9 1.0

Chlorine binding site 2 out of 4 in the Human Clc-3


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Clc-3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl902 b:33.2 occ:1.00 H A:LEU526 2.4 22.6 1.0 HH A:TYR630 2.4 26.4 1.0 HA3 A:GLY283 3.0 24.7 1.0 HB2 A:SER239 3.0 27.7 1.0 HG A:SER239 3.0 27.8 1.0 HD2 A:PHE527 3.0 26.3 1.0 HA2 A:GLY525 3.1 22.6 1.0 HD12 A:ILE241 3.1 26.4 1.0 OG A:SER239 3.1 36.9 1.0 OH A:TYR630 3.2 25.8 1.0 N A:LEU526 3.2 15.6 1.0 HE1 A:TYR630 3.4 24.3 1.0 CB A:SER239 3.5 28.6 1.0 H A:PHE527 3.6 24.6 1.0 HE2 A:PHE527 3.7 27.1 1.0 HB3 A:LEU526 3.7 22.5 1.0 CD2 A:PHE527 3.7 25.0 1.0 HD11 A:ILE241 3.7 25.0 1.0 CA A:GLY525 3.8 15.2 1.0 HD3 A:PRO284 3.8 25.7 1.0 CD1 A:ILE241 3.9 23.2 1.0 CA A:GLY283 3.9 19.6 1.0 HA3 A:GLY525 3.9 21.3 1.0 HB3 A:SER239 4.0 25.2 1.0 C A:GLY525 4.0 18.2 1.0 CE2 A:PHE527 4.0 23.2 1.0 HB2 A:LEU526 4.0 23.0 1.0 CE1 A:TYR630 4.1 22.9 1.0 CZ A:TYR630 4.1 27.5 1.0 HE1 A:PHE518 4.2 24.3 1.0 CA A:LEU526 4.2 18.3 1.0 CB A:LEU526 4.2 23.6 1.0 N A:PHE527 4.2 14.7 1.0 HA2 A:GLY283 4.3 25.4 1.0 HD13 A:ILE241 4.5 25.0 1.0 H A:GLY283 4.5 26.6 1.0 C A:GLY283 4.5 27.1 1.0 HZ A:PHE518 4.6 25.4 1.0 C A:LEU526 4.6 19.4 1.0 HG13 A:ILE241 4.6 24.1 1.0 HA A:SER239 4.7 25.3 1.0 CD A:PRO284 4.7 25.1 1.0 N A:GLY283 4.8 24.3 1.0 HB2 A:PHE527 4.8 27.4 1.0 CA A:SER239 4.8 21.0 1.0 CE1 A:PHE518 4.8 25.9 1.0 CG A:PHE527 4.8 33.0 1.0 O A:SER524 4.8 21.9 1.0 HB A:ILE241 4.8 26.1 1.0 CG1 A:ILE241 4.8 17.9 1.0 N A:PRO284 4.8 29.2 1.0 O A:HOH1047 4.9 35.3 1.0 CL A:CL901 5.0 18.9 1.0

Chlorine binding site 3 out of 4 in the Human Clc-3


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Human Clc-3 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl901 b:19.4 occ:1.00 H B:ILE528 2.5 25.2 1.0 H B:GLY283 2.6 26.4 1.0 H B:GLU282 2.7 27.4 1.0 HB2 B:PHE527 2.7 27.2 1.0 HA3 B:GLY280 2.8 21.9 1.0 HA3 B:GLY525 2.8 22.1 1.0 HG12 B:ILE528 2.9 27.1 1.0 H B:PHE527 2.9 24.7 1.0 HB2 B:GLU282 3.0 27.5 1.0 N B:ILE528 3.3 19.0 1.0 HB B:ILE528 3.4 26.3 1.0 N B:PHE527 3.5 15.4 1.0 CA B:GLY280 3.5 15.3 1.0 N B:GLY283 3.5 23.8 1.0 N B:GLU282 3.5 18.1 1.0 C B:GLY280 3.5 22.7 1.0 CG1 B:ILE528 3.6 28.3 1.0 CA B:GLY525 3.6 16.9 1.0 CB B:PHE527 3.6 23.6 1.0 C B:GLY525 3.6 18.7 1.0 HD3 B:PRO284 3.6 25.8 1.0 HG13 B:ILE528 3.7 26.4 1.0 H B:GLY280 3.7 23.7 1.0 N B:LYS281 3.8 29.6 1.0 CB B:GLU282 3.8 25.2 1.0 HD2 B:PRO284 3.9 25.7 1.0 CB B:ILE528 3.9 27.5 1.0 CA B:PHE527 3.9 22.5 1.0 O B:GLY280 3.9 20.3 1.0 N B:LEU526 3.9 14.4 1.0 H B:LYS281 4.0 28.1 1.0 N B:GLY280 4.0 22.9 1.0 O B:GLY525 4.0 28.3 1.0 HB3 B:PHE527 4.0 26.0 1.0 HD2 B:PHE527 4.0 26.4 1.0 H B:LEU526 4.0 22.6 1.0 CA B:GLU282 4.0 23.4 1.0 HA3 B:GLY283 4.1 24.2 1.0 HD3 B:PRO529 4.1 21.2 1.0 HA2 B:GLY525 4.1 23.1 1.0 C B:PHE527 4.1 23.6 1.0 OE1 B:GLU282 4.2 34.2 1.0 CD B:PRO284 4.2 25.2 1.0 HB3 B:GLU282 4.2 28.5 1.0 CA B:ILE528 4.2 22.0 1.0 C B:GLU282 4.3 22.7 1.0 HA2 B:GLY280 4.3 22.1 1.0 HD2 B:PRO529 4.3 23.7 1.0 CA B:GLY283 4.4 19.0 1.0 C B:LEU526 4.4 20.4 1.0 C B:LYS281 4.5 24.2 1.0 H B:GLY525 4.5 24.4 1.0 N B:GLY525 4.6 27.4 1.0 CA B:LYS281 4.6 24.7 1.0 CD B:PRO529 4.7 19.2 1.0 CG B:PHE527 4.7 31.8 1.0 CD2 B:PHE527 4.7 24.4 1.0 CA B:LEU526 4.7 18.7 1.0 HA B:LYS281 4.7 28.8 1.0 HA B:ILE528 4.8 25.2 1.0 HA B:PHE527 4.9 26.9 1.0 CD1 B:ILE528 4.9 22.5 1.0 CG B:GLU282 5.0 34.6 1.0 HA B:GLU282 5.0 29.0 1.0 HD11 B:ILE528 5.0 26.6 1.0 CL B:CL902 5.0 33.0 1.0 HA2 B:GLY283 5.0 25.2 1.0

Chlorine binding site 4 out of 4 in the Human Clc-3


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Human Clc-3 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl902 b:33.0 occ:1.00 H B:LEU526 2.4 22.6 1.0 HH B:TYR630 2.4 26.5 1.0 HA3 B:GLY283 2.9 24.2 1.0 HG B:SER239 3.0 27.7 1.0 HD2 B:PHE527 3.0 26.4 1.0 HB2 B:SER239 3.0 27.7 1.0 HD12 B:ILE241 3.1 26.3 1.0 HA2 B:GLY525 3.1 23.1 1.0 OG B:SER239 3.1 36.1 1.0 OH B:TYR630 3.2 25.8 1.0 N B:LEU526 3.2 14.4 1.0 HE1 B:TYR630 3.4 24.4 1.0 CB B:SER239 3.5 28.5 1.0 H B:PHE527 3.6 24.7 1.0 HE2 B:PHE527 3.7 27.3 1.0 HB3 B:LEU526 3.7 22.4 1.0 CD2 B:PHE527 3.7 24.4 1.0 HD11 B:ILE241 3.8 24.9 1.0 CA B:GLY525 3.8 16.9 1.0 HD3 B:PRO284 3.8 25.8 1.0 CD1 B:ILE241 3.9 23.3 1.0 CA B:GLY283 3.9 19.0 1.0 HA3 B:GLY525 3.9 22.1 1.0 HB3 B:SER239 4.0 25.0 1.0 CE2 B:PHE527 4.0 23.9 1.0 C B:GLY525 4.0 18.7 1.0 HB2 B:LEU526 4.1 23.1 1.0 CE1 B:TYR630 4.1 23.5 1.0 CZ B:TYR630 4.1 27.7 1.0 HE1 B:PHE518 4.1 24.2 1.0 CA B:LEU526 4.2 18.7 1.0 CB B:LEU526 4.2 23.3 1.0 N B:PHE527 4.2 15.4 1.0 HA2 B:GLY283 4.3 25.2 1.0 HD13 B:ILE241 4.5 25.0 1.0 H B:GLY283 4.5 26.4 1.0 C B:GLY283 4.5 26.8 1.0 HZ B:PHE518 4.6 25.2 1.0 C B:LEU526 4.6 20.4 1.0 HG13 B:ILE241 4.7 24.2 1.0 HA B:SER239 4.7 25.2 1.0 CD B:PRO284 4.7 25.2 1.0 HB2 B:PHE527 4.7 27.2 1.0 N B:GLY283 4.7 23.8 1.0 CG B:PHE527 4.8 31.8 1.0 CE1 B:PHE518 4.8 25.8 1.0 CA B:SER239 4.8 20.8 1.0 HB B:ILE241 4.8 26.1 1.0 O B:SER524 4.8 21.5 1.0 CG1 B:ILE241 4.8 18.2 1.0 N B:PRO284 4.8 28.8 1.0 O B:HOH1048 4.9 34.6 1.0 CL B:CL901 5.0 19.4 1.0

M.Schrecker, Y.Son, R.Planells-Cases, S.Kar, V.Vorobeva, U.Schulte, B.Fakler, T.J.Jentsch, R.K.Hite. Structural Basis of Clc-3 Inhibition By TMEM9 and Pi(3,5)P 2. Biorxiv 2025.
ISSN: ISSN 2692-8205
PubMed: 40093093
DOI: 10.1101/2025.02.28.640562