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Chlorine in PDB 9hc0: Dark Structure of the Human Metabotropic Glutamate Receptor 5 Transmembrane Domain Bound to Photoswitchable Ligand Alloswitch-1

Enzymatic activity of Dark Structure of the Human Metabotropic Glutamate Receptor 5 Transmembrane Domain Bound to Photoswitchable Ligand Alloswitch-1

All present enzymatic activity of Dark Structure of the Human Metabotropic Glutamate Receptor 5 Transmembrane Domain Bound to Photoswitchable Ligand Alloswitch-1:
3.2.1.17;

Protein crystallography data

The structure of Dark Structure of the Human Metabotropic Glutamate Receptor 5 Transmembrane Domain Bound to Photoswitchable Ligand Alloswitch-1, PDB code: 9hc0 was solved by Y.Kondo, C.Hatton, R.Cheng, M.Trabuco, H.Glover, Q.Bertrand, F.Stierli, H.P.Seidel, T.Mason, S.Sarma, F.Tellkamp, M.Kepa, F.Dworkowski, P.Mehrabi, M.Hennig, J.Standfuss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.31 / 2.33
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 143.221, 43.363, 82.642, 90, 99.86, 90
R / Rfree (%) 22.9 / 27.1

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Dark Structure of the Human Metabotropic Glutamate Receptor 5 Transmembrane Domain Bound to Photoswitchable Ligand Alloswitch-1 (pdb code 9hc0). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Dark Structure of the Human Metabotropic Glutamate Receptor 5 Transmembrane Domain Bound to Photoswitchable Ligand Alloswitch-1, PDB code: 9hc0:

Chlorine binding site 1 out of 1 in 9hc0

Go back to Chlorine Binding Sites List in 9hc0
Chlorine binding site 1 out of 1 in the Dark Structure of the Human Metabotropic Glutamate Receptor 5 Transmembrane Domain Bound to Photoswitchable Ligand Alloswitch-1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Dark Structure of the Human Metabotropic Glutamate Receptor 5 Transmembrane Domain Bound to Photoswitchable Ligand Alloswitch-1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1206

b:93.0
occ:1.00
 CL A:4YI1206 0.0 93.0 1.0
C A:4YI1206 1.7 45.0 1.0
C1 A:4YI1206 2.7 46.5 1.0
C5 A:4YI1206 2.7 40.6 1.0
N A:4YI1206 2.8 40.9 1.0
C6 A:4YI1206 3.1 33.9 1.0
O1 A:4YI1206 3.4 30.2 1.0
CE3 A:TRP785 3.7 31.4 1.0
CD1 A:LEU744 3.8 47.8 1.0
O A:TRP785 3.8 33.0 1.0
C7 A:4YI1206 3.9 30.9 1.0
C2 A:4YI1206 4.0 40.7 1.0
C4 A:4YI1206 4.0 35.6 1.0
CD2 A:TRP785 4.1 25.2 1.0
C17 A:4YI1206 4.1 33.3 1.0
O A:4YI1206 4.2 40.7 1.0
CA A:TRP785 4.2 30.6 1.0
CZ3 A:TRP785 4.3 32.2 1.0
CB A:PHE788 4.3 36.0 1.0
C18 A:4YI1206 4.3 33.8 1.0
CB A:TRP785 4.4 35.5 1.0
CG A:TRP785 4.4 27.2 1.0
C A:TRP785 4.5 28.2 1.0
C3 A:4YI1206 4.5 38.7 1.0
O A:PHE788 4.6 51.9 1.0
C A:PHE788 4.6 41.0 1.0
CG2 A:VAL789 4.8 38.6 1.0
CD2 A:LEU744 4.8 41.1 1.0
CG A:LEU744 4.9 41.5 1.0
CE2 A:TRP785 5.0 38.6 1.0
N A:VAL789 5.0 44.1 1.0

Reference:

Y.Kondo, C.Hatton, R.Cheng, M.Trabuco, H.Glover, Q.Bertrand, F.Stierli, H.P.Seidel, T.Mason, S.Sarma, F.Tellkamp, M.Kepa, F.Dworkowski, P.Mehrabi, M.Hennig, J.Standfuss. Apo-State Structure of the Metabotropic Glutamate Receptor 5 Transmembrane Domain Obtained Using A Photoswitchable Ligand. Protein Sci. V. 34 70104 2025.
ISSN: ESSN 1469-896X
PubMed: 40521617
DOI: 10.1002/PRO.70104
Page generated: Sun Jul 13 17:00:07 2025

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