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Chlorine in PDB 1cjk: Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5'-(Alpha Thio)-Triphosphate (Rp), Mg, and Mn

Enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5'-(Alpha Thio)-Triphosphate (Rp), Mg, and Mn

All present enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5'-(Alpha Thio)-Triphosphate (Rp), Mg, and Mn:
4.6.1.1;

Protein crystallography data

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5'-(Alpha Thio)-Triphosphate (Rp), Mg, and Mn, PDB code: 1cjk was solved by J.J.G.Tesmer, S.R.Sprang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 3.00
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 118.900, 134.900, 72.200, 90.00, 90.00, 90.00
R / Rfree (%) 22 / 26.6

Other elements in 1cjk:

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5'-(Alpha Thio)-Triphosphate (Rp), Mg, and Mn also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Manganese (Mn) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5'-(Alpha Thio)-Triphosphate (Rp), Mg, and Mn (pdb code 1cjk). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5'-(Alpha Thio)-Triphosphate (Rp), Mg, and Mn, PDB code: 1cjk:

Chlorine binding site 1 out of 1 in 1cjk

Go back to Chlorine Binding Sites List in 1cjk
Chlorine binding site 1 out of 1 in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5'-(Alpha Thio)-Triphosphate (Rp), Mg, and Mn


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5'-(Alpha Thio)-Triphosphate (Rp), Mg, and Mn within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl404

b:46.7
occ:1.00
 O C:HOH406 3.0 6.2 1.0
O C:HOH413 3.2 33.9 1.0
O C:HOH408 3.3 26.0 1.0
N C:ALA249 3.3 24.7 1.0
CB C:ALA249 3.6 26.2 1.0
CB C:SER51 3.7 21.9 1.0
CB C:ALA48 3.7 22.4 1.0
CA C:ALA249 4.1 26.1 1.0
CB C:ALA269 4.2 26.3 1.0
CA C:VAL248 4.2 20.3 1.0
C C:VAL248 4.2 22.9 1.0
CG1 C:VAL248 4.4 20.3 1.0
CA C:SER51 4.4 21.6 1.0
O C:ARG265 4.5 31.7 1.0
CA C:ALA48 4.6 24.2 1.0
N C:ALA48 4.6 23.0 1.0
OG C:SER51 4.7 23.1 1.0
O C:VAL247 4.8 22.2 1.0
C C:ALA48 4.8 25.2 1.0
O C:GLY49 4.9 26.4 1.0
N C:SER51 4.9 24.1 1.0
O C:ALA48 4.9 26.1 1.0
O C:ALA249 4.9 27.7 1.0
CB C:VAL248 4.9 18.6 1.0
C C:ALA249 5.0 27.1 1.0
CA C:ALA269 5.0 25.6 1.0

Reference:

J.J.Tesmer, R.K.Sunahara, R.A.Johnson, G.Gosselin, A.G.Gilman, S.R.Sprang. Two-Metal-Ion Catalysis in Adenylyl Cyclase. Science V. 285 756 1999.
ISSN: ISSN 0036-8075
PubMed: 10427002
DOI: 10.1126/SCIENCE.285.5428.756
Page generated: Fri Jul 19 21:21:24 2024

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