Chlorine in PDB 1el5: Complex of Monomeric Sarcosine Oxidase with the Inhibitor Dimethylglycine

All present enzymatic activity of Complex of Monomeric Sarcosine Oxidase with the Inhibitor Dimethylglycine:
1.5.3.1;

The structure of Complex of Monomeric Sarcosine Oxidase with the Inhibitor Dimethylglycine, PDB code: 1el5 was solved by M.A.Wagner, P.Trickey, Z.-W.Chen, F.S.Mathews, M.S.Jorns, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	500.00 / 1.80
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	72.865, 69.503, 73.498, 90.00, 94.25, 90.00
R / Rfree (%)	16.5 / 20.8

The binding sites of Chlorine atom in the Complex of Monomeric Sarcosine Oxidase with the Inhibitor Dimethylglycine (pdb code 1el5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Complex of Monomeric Sarcosine Oxidase with the Inhibitor Dimethylglycine, PDB code: 1el5:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Complex of Monomeric Sarcosine Oxidase with the Inhibitor Dimethylglycine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Complex of Monomeric Sarcosine Oxidase with the Inhibitor Dimethylglycine within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl804 b:16.9 occ:1.00 O3' A:FAD400 3.0 11.4 1.0 O A:HOH842 3.1 19.0 1.0 N A:GLY344 3.1 10.7 1.0 N A:THR318 3.4 16.5 1.0 C3' A:FAD400 3.4 10.2 1.0 N A:SER343 3.6 13.2 1.0 CA A:TYR317 3.6 17.3 1.0 C A:PHE342 3.7 13.2 1.0 CB A:PHE342 3.8 15.4 1.0 CA A:GLY344 3.8 13.2 1.0 C A:TYR317 4.0 17.1 1.0 O A:HOH837 4.0 14.3 1.0 C A:SER343 4.1 14.4 1.0 CA A:PHE342 4.1 13.3 1.0 O A:MET316 4.1 14.0 1.0 CA A:SER343 4.2 13.7 1.0 O A:PHE342 4.2 15.5 1.0 C1' A:FAD400 4.3 10.8 1.0 C5' A:FAD400 4.3 13.2 1.0 CB A:TYR317 4.3 14.4 1.0 O A:THR318 4.4 15.3 1.0 N A:PHE342 4.4 13.1 1.0 CA A:THR318 4.5 17.6 1.0 C2' A:FAD400 4.6 11.9 1.0 OG A:SER43 4.6 18.0 1.0 CB A:THR318 4.6 18.0 1.0 C4' A:FAD400 4.6 12.0 1.0 N A:TYR317 4.7 13.9 1.0 CD1 A:TYR317 4.7 11.7 1.0 C A:GLY344 4.8 13.2 1.0 OG1 A:THR318 4.8 20.9 1.0 C A:THR318 4.8 17.7 1.0 CB A:SER43 4.8 13.8 1.0 C A:MET316 4.9 14.7 1.0 CG A:TYR317 4.9 16.3 1.0 N A:HIS345 4.9 12.8 1.0

Chlorine binding site 2 out of 2 in the Complex of Monomeric Sarcosine Oxidase with the Inhibitor Dimethylglycine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Complex of Monomeric Sarcosine Oxidase with the Inhibitor Dimethylglycine within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl814 b:18.1 occ:1.00 O B:HOH833 2.9 15.0 1.0 O3' B:FAD400 3.0 14.2 1.0 N B:GLY344 3.2 13.4 1.0 C3' B:FAD400 3.4 13.6 1.0 N B:THR318 3.4 15.4 1.0 CA B:TYR317 3.6 17.0 1.0 N B:SER343 3.6 12.8 1.0 C B:PHE342 3.8 14.8 1.0 CA B:GLY344 3.9 13.2 1.0 CB B:PHE342 3.9 14.8 1.0 C B:TYR317 3.9 17.7 1.0 O B:MET316 4.0 16.6 1.0 O B:HOH820 4.1 14.7 1.0 C B:SER343 4.1 14.5 1.0 CA B:PHE342 4.2 13.0 1.0 CA B:SER343 4.2 11.4 1.0 C1' B:FAD400 4.2 12.8 1.0 C5' B:FAD400 4.2 13.0 1.0 O B:PHE342 4.2 14.6 1.0 CB B:TYR317 4.3 14.1 1.0 N B:PHE342 4.4 15.0 1.0 O B:THR318 4.4 12.1 1.0 CA B:THR318 4.5 16.0 1.0 OG B:SER43 4.5 13.8 1.0 C2' B:FAD400 4.5 12.5 1.0 C4' B:FAD400 4.6 13.0 1.0 CB B:THR318 4.6 17.0 1.0 N B:TYR317 4.7 16.5 1.0 CD1 B:TYR317 4.7 11.9 1.0 CB B:SER43 4.7 12.3 1.0 C B:MET316 4.8 16.1 1.0 OG1 B:THR318 4.8 18.4 1.0 C B:GLY344 4.8 13.6 1.0 C B:THR318 4.8 15.2 1.0 CG B:TYR317 4.8 14.1 1.0 N B:HIS345 4.9 11.6 1.0

M.A.Wagner, P.Trickey, Z.W.Chen, F.S.Mathews, M.S.Jorns. Monomeric Sarcosine Oxidase: 1. Flavin Reactivity and Active Site Binding Determinants. Biochemistry V. 39 8813 2000.
ISSN: ISSN 0006-2960
PubMed: 10913292
DOI: 10.1021/BI000349Z