Chlorine in PDB 1em6: Human Liver Glycogen Phosphorylase A Complexed with Glcnac and Cp-526, 423

All present enzymatic activity of Human Liver Glycogen Phosphorylase A Complexed with Glcnac and Cp-526, 423:
2.4.1.1;

The structure of Human Liver Glycogen Phosphorylase A Complexed with Glcnac and Cp-526, 423, PDB code: 1em6 was solved by V.L.Rath, M.Ammirati, D.E.Danley, J.L.Ekstrom, T.R.Hynes, T.V.Olson, D.J.Hoover, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	99.00 / 2.20
Space group	P 31
Cell size a, b, c (Å), α, β, γ (°)	123.314, 123.314, 122.319, 90.00, 90.00, 120.00
R / Rfree (%)	23.3 / 26.4

The binding sites of Chlorine atom in the Human Liver Glycogen Phosphorylase A Complexed with Glcnac and Cp-526, 423 (pdb code 1em6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human Liver Glycogen Phosphorylase A Complexed with Glcnac and Cp-526, 423, PDB code: 1em6:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Human Liver Glycogen Phosphorylase A Complexed with Glcnac and Cp-526, 423


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Liver Glycogen Phosphorylase A Complexed with Glcnac and Cp-526, 423 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl862 b:13.5 occ:1.00 CL10 A:CP4862 0.0 13.5 1.0 C7 A:CP4862 1.7 17.2 1.0 C3 A:CP4862 2.7 17.5 1.0 C8 A:CP4862 2.7 17.7 1.0 CE3 A:TRP67 3.5 24.8 1.0 CG1 A:VAL64 3.6 25.7 1.0 CG A:ARG60 3.6 21.9 1.0 O A:ARG60 3.6 20.9 1.0 CB A:LEU63 3.7 24.0 1.0 CZ3 A:TRP67 3.8 24.8 1.0 N A:VAL64 3.9 25.3 1.0 C0 A:CP4862 4.0 18.5 1.0 C5 A:CP4862 4.1 19.0 1.0 CD1 A:LEU63 4.1 23.9 1.0 CG A:PRO229 4.2 19.6 1.0 CA A:VAL64 4.3 25.7 1.0 C A:LEU63 4.4 25.0 1.0 CD A:ARG60 4.4 22.8 1.0 O A:HOH2053 4.4 17.6 1.0 C A:ARG60 4.5 21.4 1.0 CG A:LEU63 4.6 24.2 1.0 C1 A:CP4862 4.6 18.8 1.0 CB A:PRO229 4.6 20.0 1.0 CA A:LEU63 4.6 24.6 1.0 CB A:VAL64 4.6 26.1 1.0 CD2 A:TRP67 4.7 24.9 1.0 CB A:ARG60 4.8 21.7 1.0 CG2 B:VAL40 4.8 28.2 1.0 CD A:PRO229 4.9 19.4 1.0 NE A:ARG60 4.9 22.7 1.0 CA A:ARG60 4.9 21.6 1.0

Chlorine binding site 2 out of 2 in the Human Liver Glycogen Phosphorylase A Complexed with Glcnac and Cp-526, 423


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Liver Glycogen Phosphorylase A Complexed with Glcnac and Cp-526, 423 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl862 b:16.5 occ:1.00 CL33 A:CP4862 0.0 16.5 1.0 C32 A:CP4862 1.7 18.8 1.0 C30 A:CP4862 2.7 18.9 1.0 C31 A:CP4862 2.8 19.2 1.0 O B:ARG60 3.5 21.7 1.0 CG1 B:VAL64 3.5 26.2 1.0 CB B:LEU63 3.6 24.2 1.0 CG B:ARG60 3.6 22.7 1.0 CE3 B:TRP67 3.7 24.4 1.0 N B:VAL64 3.8 25.2 1.0 CZ3 B:TRP67 3.9 24.7 1.0 C28 A:CP4862 4.0 19.6 1.0 CD1 B:LEU63 4.1 24.5 1.0 C29 A:CP4862 4.1 19.4 1.0 CA B:VAL64 4.3 25.8 1.0 C B:LEU63 4.3 24.9 1.0 CG B:PRO229 4.3 20.6 1.0 C B:ARG60 4.3 22.3 1.0 CD B:ARG60 4.4 23.0 1.0 CG B:LEU63 4.5 24.4 1.0 CA B:LEU63 4.5 24.6 1.0 O B:HOH2067 4.5 20.5 1.0 CB B:VAL64 4.5 26.1 1.0 C27 A:CP4862 4.6 19.9 1.0 CB B:PRO229 4.7 20.2 1.0 CB B:ARG60 4.7 22.4 1.0 CA B:ARG60 4.8 22.2 1.0 CG2 A:VAL40 4.8 27.4 1.0 CD2 B:TRP67 4.8 24.9 1.0 NE B:ARG60 4.9 23.3 1.0 N B:LEU63 4.9 24.3 1.0 O B:LEU63 5.0 24.6 1.0 CD B:PRO229 5.0 20.3 1.0

V.L.Rath, M.Ammirati, D.E.Danley, J.L.Ekstrom, E.M.Gibbs, T.R.Hynes, A.M.Mathiowetz, R.K.Mcpherson, T.V.Olson, J.L.Treadway, D.J.Hoover. Human Liver Glycogen Phosphorylase Inhibitors Bind at A New Allosteric Site. Chem.Biol. V. 7 677 2000.
ISSN: ISSN 1074-5521
PubMed: 10980448
DOI: 10.1016/S1074-5521(00)00004-1