Chlorine in PDB 1iqn: Human Coagulation Factor Xa in Complex with M55192

All present enzymatic activity of Human Coagulation Factor Xa in Complex with M55192:
3.4.21.6;

The structure of Human Coagulation Factor Xa in Complex with M55192, PDB code: 1iqn was solved by I.Shiromizu, T.Matsusue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	8.00 / 2.60
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	72.170, 78.270, 56.620, 90.00, 90.00, 90.00
R / Rfree (%)	n/a / n/a

The structure of Human Coagulation Factor Xa in Complex with M55192 also contains other interesting chemical elements:

Calcium

(Ca)

1 atom

The binding sites of Chlorine atom in the Human Coagulation Factor Xa in Complex with M55192 (pdb code 1iqn). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Coagulation Factor Xa in Complex with M55192, PDB code: 1iqn:

Chlorine binding site 1 out of 1 in the Human Coagulation Factor Xa in Complex with M55192


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Coagulation Factor Xa in Complex with M55192 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl401 b:26.7 occ:1.00 CL7 A:XMC401 0.0 26.7 1.0 C11 A:XMC401 1.5 21.2 1.0 C9 A:XMC401 2.6 20.7 1.0 C10 A:XMC401 2.6 22.6 1.0 CZ A:TYR228 3.4 22.7 1.0 CE1 A:TYR228 3.5 23.0 1.0 N A:ILE227 3.6 21.6 1.0 CA A:GLY226 3.6 25.2 1.0 OH A:TYR228 3.7 21.0 1.0 O A:TRP215 3.8 29.1 1.0 C A:GLY226 3.8 24.2 1.0 CE2 A:TYR228 3.9 22.6 1.0 CB A:ALA190 3.9 24.9 1.0 CG1 A:VAL213 3.9 19.1 1.0 C3 A:XMC401 3.9 21.2 1.0 C8 A:XMC401 3.9 21.3 1.0 O A:ILE227 4.0 24.2 1.0 CD1 A:TYR228 4.0 21.1 1.0 C A:ILE227 4.2 23.6 1.0 OD1 A:ASP189 4.3 30.9 1.0 CD2 A:TYR228 4.3 22.7 1.0 O A:HOH537 4.3 16.9 1.0 CG A:TYR228 4.4 21.5 1.0 C6 A:XMC401 4.5 21.9 1.0 CA A:ILE227 4.5 22.5 1.0 N A:SER214 4.6 23.7 1.0 C A:TRP215 4.7 29.6 1.0 CA A:VAL213 4.7 20.3 1.0 O A:GLY226 4.7 25.0 1.0 CB A:VAL213 4.8 21.1 1.0 N A:TRP215 4.8 30.6 1.0 N A:TYR228 4.9 23.1 1.0

T.Matsusue, I.Shiromizu, A.Okamoto, K.Nakayama, H.Nishida, T.Mukaihira, Y.Miyazaki, F.Saitou, H.Morishita, S.Ohnishi, H.Mochizuki. Factor Xa Specific Inhibitor That Induces the Novel Binding Model in Complex with Human Fxa To Be Published.