Atomistry » Chlorine » PDB 1mkp-1nc4 » 1n4q
Atomistry »
  Chlorine »
    PDB 1mkp-1nc4 »
      1n4q »

Chlorine in PDB 1n4q: Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide

Enzymatic activity of Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide

All present enzymatic activity of Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide:
2.5.1.58; 2.5.1.59;

Protein crystallography data

The structure of Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide, PDB code: 1n4q was solved by J.S.Taylor, T.S.Reid, P.J.Casey, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.99 / 2.40
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 271.055, 268.033, 184.971, 90.00, 131.73, 90.00
R / Rfree (%) 21.4 / 23.4

Other elements in 1n4q:

The structure of Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide also contains other interesting chemical elements:

Zinc (Zn) 6 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide (pdb code 1n4q). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 7 binding sites of Chlorine where determined in the Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide, PDB code: 1n4q:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7;

Chlorine binding site 1 out of 7 in 1n4q

Go back to Chlorine Binding Sites List in 1n4q
Chlorine binding site 1 out of 7 in the Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1301

b:65.2
occ:1.00
 NH2 C:ARG287 2.8 78.7 1.0
NH2 C:ARG291 3.2 65.7 1.0
O I:HOH409 3.5 65.7 1.0
NE C:ARG253 3.6 75.7 1.0
OH C:TYR292 3.7 57.9 1.0
CZ C:ARG287 3.8 78.0 1.0
NH2 C:ARG253 3.8 78.1 1.0
NE C:ARG287 3.9 76.3 1.0
NH1 C:ARG291 4.0 63.4 1.0
CZ C:ARG291 4.1 64.5 1.0
CZ C:ARG253 4.2 78.0 1.0
CG2 I:VAL64 4.5 60.7 1.0
CG C:ARG253 4.5 70.2 1.0
CZ C:TYR292 4.6 56.9 1.0
CD C:ARG253 4.6 72.9 1.0
CE1 C:TYR292 4.8 57.3 1.0
CD2 C:LEU256 4.9 60.0 1.0

Chlorine binding site 2 out of 7 in 1n4q

Go back to Chlorine Binding Sites List in 1n4q
Chlorine binding site 2 out of 7 in the Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1306

b:45.4
occ:1.00
 N D:GLN287 3.1 39.7 1.0
N D:PHE286 3.1 40.9 1.0
O D:HOH1442 3.4 53.6 1.0
C D:LYS284 3.5 46.6 1.0
N D:ILE285 3.6 42.5 1.0
CB D:PHE286 3.7 38.0 1.0
CB D:GLN287 3.7 40.9 1.0
CG D:GLN287 3.8 46.3 1.0
CA D:PHE286 3.8 39.6 1.0
CA D:LYS284 3.8 47.2 1.0
O D:LYS284 3.8 46.6 1.0
C D:ILE285 3.9 40.9 1.0
C D:PHE286 3.9 41.0 1.0
CA D:GLN287 4.0 41.8 1.0
CA D:ILE285 4.1 40.1 1.0
CD D:LYS281 4.2 48.5 1.0
NE2 D:GLN287 4.2 49.3 1.0
CD D:GLN287 4.4 48.4 1.0
CA D:LYS281 4.4 43.0 1.0
O D:LYS281 4.5 43.4 1.0
O D:LEU280 4.6 40.7 1.0
N D:LYS284 4.7 48.7 1.0
NZ D:LYS281 4.8 50.9 1.0
O D:ILE285 4.9 40.1 1.0
CB D:LYS284 4.9 47.7 1.0
CE D:LYS281 4.9 52.8 1.0
C D:LYS281 4.9 42.3 1.0
CG D:PHE286 4.9 37.8 1.0

Chlorine binding site 3 out of 7 in 1n4q

Go back to Chlorine Binding Sites List in 1n4q
Chlorine binding site 3 out of 7 in the Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl1309

b:51.9
occ:1.00
 N F:PHE286 3.4 43.1 1.0
N F:GLN287 3.4 44.6 1.0
C F:LYS284 3.5 44.5 1.0
N F:ILE285 3.7 43.6 1.0
CA F:LYS284 3.7 44.0 1.0
O F:LYS284 3.9 45.8 1.0
CB F:GLN287 3.9 47.0 1.0
CG F:GLN287 3.9 47.2 1.0
CB F:PHE286 3.9 46.0 1.0
NE2 F:GLN287 4.1 43.2 1.0
CA F:PHE286 4.1 43.3 1.0
CD F:LYS281 4.1 51.9 1.0
C F:ILE285 4.1 43.1 1.0
C F:PHE286 4.2 44.6 1.0
CA F:ILE285 4.2 42.2 1.0
CA F:GLN287 4.2 46.7 1.0
O F:LYS281 4.3 44.5 1.0
CD F:GLN287 4.4 47.8 1.0
CA F:LYS281 4.4 44.2 1.0
O F:LEU280 4.6 42.8 1.0
N F:LYS284 4.7 46.1 1.0
CB F:LYS284 4.7 45.4 1.0
CE F:LYS281 4.8 55.0 1.0
CG F:LYS281 4.8 48.3 1.0
C F:LYS281 4.8 43.7 1.0
NZ F:LYS281 4.9 58.2 1.0

Chlorine binding site 4 out of 7 in 1n4q

Go back to Chlorine Binding Sites List in 1n4q
Chlorine binding site 4 out of 7 in the Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Cl1311

b:59.8
occ:1.00
 O G:HOH1323 2.3 54.2 1.0
NH2 G:ARG287 3.3 74.5 1.0
OH G:TYR292 3.4 53.4 1.0
NH2 G:ARG291 3.6 51.1 1.0
NE G:ARG253 3.8 64.8 1.0
NE G:ARG287 4.0 70.1 1.0
CZ G:ARG287 4.0 72.5 1.0
NH1 G:ARG291 4.1 54.4 1.0
CG G:ARG253 4.3 60.5 1.0
CZ G:ARG291 4.4 55.3 1.0
CD2 G:LEU256 4.4 48.9 1.0
CZ G:TYR292 4.4 54.4 1.0
NH2 G:ARG253 4.5 65.0 1.0
CD G:ARG253 4.6 63.1 1.0
CZ G:ARG253 4.6 65.1 1.0
CE1 G:TYR292 4.6 53.3 1.0
O G:HOH1365 4.8 57.5 1.0

Chlorine binding site 5 out of 7 in 1n4q

Go back to Chlorine Binding Sites List in 1n4q
Chlorine binding site 5 out of 7 in the Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Cl1312

b:59.8
occ:1.00
 N H:PHE286 3.2 54.4 1.0
N H:GLN287 3.2 55.7 1.0
C H:LYS284 3.5 55.7 1.0
N H:ILE285 3.6 53.9 1.0
CB H:PHE286 3.8 57.1 1.0
CA H:LYS284 3.8 56.2 1.0
CB H:GLN287 3.8 57.7 1.0
CG H:GLN287 3.8 61.2 1.0
O H:LYS284 3.8 56.1 1.0
CA H:PHE286 3.9 55.9 1.0
NE2 H:GLN287 4.0 60.4 1.0
C H:ILE285 4.0 53.8 1.0
C H:PHE286 4.0 56.0 1.0
CD H:LYS281 4.1 65.5 1.0
CA H:GLN287 4.1 56.8 1.0
CA H:ILE285 4.1 53.5 1.0
CD H:GLN287 4.3 61.5 1.0
CA H:LYS281 4.3 58.3 1.0
O H:LYS281 4.4 58.8 1.0
NZ H:LYS281 4.4 70.5 1.0
CE H:LYS281 4.6 70.3 1.0
O H:LEU280 4.6 58.5 1.0
N H:LYS284 4.7 57.9 1.0
CB H:LYS284 4.8 55.0 1.0
C H:LYS281 4.8 57.5 1.0
CG H:PHE286 5.0 57.3 1.0

Chlorine binding site 6 out of 7 in 1n4q

Go back to Chlorine Binding Sites List in 1n4q
Chlorine binding site 6 out of 7 in the Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Cl1315

b:60.2
occ:1.00
 N J:PHE286 3.2 56.8 1.0
N J:GLN287 3.2 61.4 1.0
C J:LYS284 3.4 57.3 1.0
NZ J:LYS281 3.6 68.9 1.0
N J:ILE285 3.6 55.8 1.0
CB J:GLN287 3.7 62.4 1.0
CG J:GLN287 3.8 67.0 1.0
CB J:PHE286 3.8 60.1 1.0
CA J:LYS284 3.8 58.1 1.0
O J:LYS284 3.8 58.0 1.0
CA J:PHE286 3.8 60.0 1.0
C J:ILE285 3.9 55.6 1.0
NE2 J:GLN287 4.0 67.1 1.0
CD J:LYS281 4.0 62.5 1.0
C J:PHE286 4.0 61.0 1.0
CA J:GLN287 4.0 61.4 1.0
CA J:ILE285 4.1 54.1 1.0
CE J:LYS281 4.1 66.3 1.0
CD J:GLN287 4.2 68.4 1.0
O J:LYS281 4.4 56.8 1.0
CA J:LYS281 4.4 54.6 1.0
O J:LEU280 4.6 55.1 1.0
N J:LYS284 4.7 58.2 1.0
CB J:LYS284 4.8 60.2 1.0
C J:LYS281 4.9 54.1 1.0
O J:ILE285 4.9 55.5 1.0

Chlorine binding site 7 out of 7 in 1n4q

Go back to Chlorine Binding Sites List in 1n4q
Chlorine binding site 7 out of 7 in the Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Kkksktkcvil Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Cl1317

b:61.5
occ:1.00
 O K:HOH1332 2.3 51.8 1.0
O A:HOH418 3.0 45.0 1.0
NH2 K:ARG287 3.1 67.8 1.0
OH K:TYR292 3.1 55.0 1.0
O K:HOH1396 3.4 63.3 1.0
NE K:ARG253 3.8 65.1 1.0
NE K:ARG287 4.0 65.8 1.0
CZ K:ARG287 4.0 67.0 1.0
NH2 K:ARG291 4.0 54.9 1.0
CZ K:TYR292 4.1 53.1 1.0
NH1 K:ARG291 4.2 52.2 1.0
CE1 K:TYR292 4.2 53.4 1.0
CD2 K:LEU256 4.3 39.6 1.0
CG2 A:VAL64 4.3 46.2 1.0
CG K:ARG253 4.3 57.5 1.0
CD K:ARG253 4.5 61.1 1.0
CZ K:ARG291 4.6 54.1 1.0
NH2 K:ARG253 4.6 65.3 1.0
CZ K:ARG253 4.7 67.4 1.0
O K:HOH1381 5.0 52.9 1.0

Reference:

J.S.Taylor, T.S.Reid, K.L.Terry, P.J.Casey, L.S.Beese. Structure of Mammalian Protein Geranylgeranyltransferase Type-I Embo J. V. 22 5963 2003.
ISSN: ISSN 0261-4189
PubMed: 14609943
DOI: 10.1093/EMBOJ/CDG571
Page generated: Thu Jul 10 18:19:13 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy