Chlorine in PDB 1so7: Maltose-Induced Structure of the Human Cytolsolic Sialidase NEU2

All present enzymatic activity of Maltose-Induced Structure of the Human Cytolsolic Sialidase NEU2:
3.2.1.18;

The structure of Maltose-Induced Structure of the Human Cytolsolic Sialidase NEU2, PDB code: 1so7 was solved by L.M.G.Chavas, P.Fusi, C.Tringali, B.Venerando, G.Tettamanti, R.Kato, E.Monti, S.Wakatsuki, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.49
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	145.690, 145.690, 64.380, 90.00, 90.00, 120.00
R / Rfree (%)	20.2 / 21.3

The binding sites of Chlorine atom in the Maltose-Induced Structure of the Human Cytolsolic Sialidase NEU2 (pdb code 1so7). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Maltose-Induced Structure of the Human Cytolsolic Sialidase NEU2, PDB code: 1so7:

Chlorine binding site 1 out of 1 in the Maltose-Induced Structure of the Human Cytolsolic Sialidase NEU2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Maltose-Induced Structure of the Human Cytolsolic Sialidase NEU2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl381 b:27.1 occ:1.00 N A:GLY30 3.1 22.5 1.0 O A:HOH472 3.2 32.1 1.0 O A:HOH490 3.3 41.5 1.0 N A:GLN31 3.3 23.4 1.0 CA A:GLY30 3.5 23.3 1.0 CB A:LEU28 3.6 20.1 1.0 CG A:GLN31 3.8 29.1 1.0 C A:LEU28 3.9 18.6 1.0 C A:GLY30 3.9 24.6 1.0 CE1 A:TYR91 3.9 27.1 1.0 N A:PRO29 4.0 20.3 1.0 CA A:LEU28 4.0 18.7 1.0 CD A:PRO29 4.1 20.9 1.0 C A:PRO29 4.2 21.7 1.0 CB A:GLN31 4.3 25.7 1.0 O A:LEU28 4.3 19.1 1.0 OH A:TYR91 4.3 30.2 1.0 CZ A:TYR91 4.3 27.3 1.0 ND1 A:HIS132 4.4 32.4 1.0 CA A:GLN31 4.4 23.4 1.0 CG A:PRO29 4.5 22.5 1.0 CA A:PRO29 4.6 21.2 1.0 CD1 A:TYR91 4.7 26.3 1.0 CG A:LEU28 4.7 21.2 1.0 CE1 A:HIS132 4.7 33.3 1.0 CD A:GLN31 4.8 31.5 1.0 CD2 A:LEU28 4.8 21.0 1.0 OE1 A:GLN31 4.9 34.4 1.0 CD1 A:LEU28 4.9 22.1 1.0

L.M.G.Chavas, C.Tringali, P.Fusi, B.Venerando, G.Tettamanti, R.Kato, E.Monti, S.Wakatsuki. Crystal Structure of the Human Cytosolic Sialidase NEU2: Evidence For the Dynamic Nature of Substrate Recognition J.Biol.Chem. V. 280 469 2005.
ISSN: ISSN 0021-9258
PubMed: 15501818
DOI: 10.1074/JBC.M411506200