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Chlorine in PDB 1tnz: Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Rrcvll Peptide Derived From CDC42 Splice Isoform-2

Enzymatic activity of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Rrcvll Peptide Derived From CDC42 Splice Isoform-2

All present enzymatic activity of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Rrcvll Peptide Derived From CDC42 Splice Isoform-2:
2.5.1.59;

Protein crystallography data

The structure of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Rrcvll Peptide Derived From CDC42 Splice Isoform-2, PDB code: 1tnz was solved by T.S.Reid, K.L.Terry, P.J.Casey, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.96 / 2.90
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 271.262, 266.922, 185.750, 90.00, 131.91, 90.00
R / Rfree (%) 19.9 / 21.8

Other elements in 1tnz:

The structure of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Rrcvll Peptide Derived From CDC42 Splice Isoform-2 also contains other interesting chemical elements:

Zinc (Zn) 6 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Rrcvll Peptide Derived From CDC42 Splice Isoform-2 (pdb code 1tnz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Rrcvll Peptide Derived From CDC42 Splice Isoform-2, PDB code: 1tnz:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 1tnz

Go back to Chlorine Binding Sites List in 1tnz
Chlorine binding site 1 out of 3 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Rrcvll Peptide Derived From CDC42 Splice Isoform-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Rrcvll Peptide Derived From CDC42 Splice Isoform-2 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl379

b:74.6
occ:1.00
 N D:PHE286 3.1 65.5 1.0
N D:GLN287 3.2 64.2 1.0
C D:LYS284 3.4 67.7 1.0
N D:ILE285 3.5 65.1 1.0
CG D:GLN287 3.6 68.8 1.0
CB D:GLN287 3.7 64.8 1.0
O D:LYS284 3.8 68.8 1.0
CA D:LYS284 3.8 69.1 1.0
CB D:PHE286 3.8 60.7 1.0
CA D:PHE286 3.8 63.9 1.0
C D:ILE285 3.8 65.3 1.0
NE2 D:GLN287 3.8 70.9 1.0
CA D:ILE285 3.9 64.4 1.0
C D:PHE286 4.0 64.1 1.0
CA D:GLN287 4.0 65.9 1.0
CD D:GLN287 4.2 72.0 1.0
CD D:LYS281 4.3 70.8 1.0
CA D:LYS281 4.5 66.4 1.0
O D:LYS281 4.5 64.1 1.0
O D:LEU280 4.6 68.4 1.0
N D:LYS284 4.7 69.9 1.0
CE D:LYS281 4.8 74.9 1.0
O D:ILE285 4.8 65.9 1.0
CB D:LYS284 4.8 70.2 1.0
C D:LYS281 5.0 64.2 1.0

Chlorine binding site 2 out of 3 in 1tnz

Go back to Chlorine Binding Sites List in 1tnz
Chlorine binding site 2 out of 3 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Rrcvll Peptide Derived From CDC42 Splice Isoform-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Rrcvll Peptide Derived From CDC42 Splice Isoform-2 within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl379

b:72.9
occ:1.00
 N F:GLN287 3.4 61.7 1.0
N F:PHE286 3.4 62.1 1.0
C F:LYS284 3.6 62.8 1.0
N F:ILE285 3.7 62.1 1.0
NE2 F:GLN287 3.8 63.1 1.0
CB F:GLN287 3.8 62.9 1.0
CA F:LYS284 3.9 63.2 1.0
CG F:GLN287 3.9 64.4 1.0
O F:LYS284 3.9 63.2 1.0
CB F:PHE286 4.0 62.3 1.0
CA F:PHE286 4.0 62.1 1.0
C F:ILE285 4.1 62.1 1.0
CA F:GLN287 4.2 62.8 1.0
CD F:GLN287 4.2 66.0 1.0
C F:PHE286 4.2 61.4 1.0
CA F:ILE285 4.2 61.5 1.0
CD F:LYS281 4.3 67.9 1.0
O F:LYS281 4.5 63.0 1.0
CA F:LYS281 4.5 62.7 1.0
CE F:LYS281 4.6 69.5 1.0
O F:LEU280 4.8 64.1 1.0
N F:LYS284 4.8 63.2 1.0
CB F:LYS284 4.8 65.3 1.0
CG F:LYS281 5.0 64.4 1.0
NZ F:LYS281 5.0 71.5 1.0

Chlorine binding site 3 out of 3 in 1tnz

Go back to Chlorine Binding Sites List in 1tnz
Chlorine binding site 3 out of 3 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Rrcvll Peptide Derived From CDC42 Splice Isoform-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Rrcvll Peptide Derived From CDC42 Splice Isoform-2 within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Cl379

b:87.6
occ:1.00
 N H:PHE286 3.3 74.0 1.0
C H:LYS284 3.4 75.9 1.0
N H:GLN287 3.4 74.6 1.0
N H:ILE285 3.5 74.8 1.0
CA H:LYS284 3.6 76.3 1.0
CD H:LYS281 3.6 80.5 1.0
O H:LYS284 3.8 75.9 1.0
CG H:GLN287 3.8 78.9 1.0
CB H:PHE286 3.9 74.1 1.0
CB H:GLN287 3.9 75.0 1.0
NE2 H:GLN287 4.0 81.0 1.0
CA H:PHE286 4.0 74.1 1.0
C H:ILE285 4.0 73.5 1.0
CA H:ILE285 4.1 73.7 1.0
C H:PHE286 4.2 73.5 1.0
O H:LYS281 4.3 77.7 1.0
CA H:GLN287 4.3 75.4 1.0
CD H:GLN287 4.3 80.8 1.0
CA H:LYS281 4.4 76.4 1.0
CE H:LYS281 4.4 83.2 1.0
O H:LEU280 4.6 77.3 1.0
N H:LYS284 4.6 77.8 1.0
CB H:LYS284 4.7 75.3 1.0
C H:LYS281 4.8 75.7 1.0
CG H:LYS281 4.9 78.6 1.0

Reference:

T.S.Reid, K.L.Terry, P.J.Casey, L.S.Beese. Crystallographic Analysis of Caax Prenyltransferases Complexed with Substrates Defines Rules of Protein Substrate Selectivity. J.Mol.Biol. V. 343 417 2004.
ISSN: ISSN 0022-2836
PubMed: 15451670
DOI: 10.1016/J.JMB.2004.08.056
Page generated: Thu Jul 10 19:38:33 2025

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