Chlorine in PDB 1u46: Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1

All present enzymatic activity of Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1:
2.7.1.112;

The structure of Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1, PDB code: 1u46 was solved by J.C.Lougheed, R.H.Chen, P.Mak, T.J.Stout, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	81.176, 43.401, 84.452, 90.00, 111.82, 90.00
R / Rfree (%)	19.9 / 24.9

The binding sites of Chlorine atom in the Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1 (pdb code 1u46). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1, PDB code: 1u46:

Chlorine binding site 1 out of 1 in the Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1 b:29.8 occ:1.00 O B:HOH480 3.0 46.6 1.0 N B:GLN287 3.2 30.8 1.0 NH1 B:ARG251 3.3 25.4 1.0 NH2 B:ARG251 3.3 22.3 1.0 NE B:ARG290 3.5 42.4 1.0 CD B:ARG290 3.6 43.5 1.0 CG B:GLN287 3.6 34.6 1.0 CA B:MET286 3.7 28.2 1.0 CZ B:ARG251 3.8 25.4 1.0 CB B:GLN287 3.9 33.0 1.0 CG B:MET286 3.9 27.4 1.0 C B:MET286 3.9 28.7 1.0 CE1 B:TYR284 4.0 42.4 1.0 NH2 B:ARG275 4.0 38.0 1.0 OE1 B:GLN287 4.0 37.9 1.0 NE B:ARG275 4.1 33.0 1.0 CA B:GLN287 4.2 32.5 1.0 O B:VAL285 4.2 29.5 1.0 CD B:GLN287 4.3 38.6 1.0 CB B:MET286 4.4 27.3 1.0 CZ B:ARG275 4.4 34.0 1.0 CZ B:ARG290 4.6 45.2 1.0 CD1 B:TYR284 4.6 38.2 1.0 CG B:ARG290 4.7 40.3 1.0 N B:MET286 4.7 27.9 1.0 CZ B:TYR284 4.9 41.6 1.0 C B:VAL285 4.9 28.9 1.0 OH B:TYR284 4.9 44.3 1.0

J.C.Lougheed, R.H.Chen, P.Mak, T.J.Stout. Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the CDC42-Associated Tyrosine Kinase ACK1. J.Biol.Chem. V. 279 44039 2004.
ISSN: ISSN 0021-9258
PubMed: 15308621
DOI: 10.1074/JBC.M406703200