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Atomistry » Chlorine » PDB 1ymd-1zch » 1z5m | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 1ymd-1zch » 1z5m » |
Chlorine in PDB 1z5m: Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1Enzymatic activity of Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1
All present enzymatic activity of Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1:
2.7.1.37; Protein crystallography data
The structure of Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1, PDB code: 1z5m
was solved by
M.Whitlow,
M.Adler,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 1z5m:
The structure of Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1
(pdb code 1z5m). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1, PDB code: 1z5m: Chlorine binding site 1 out of 1 in 1z5mGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Crystal Structure of N1-[3-[[5-Bromo-2-[[3-[(1-Pyrrolidinylcarbonyl) Amino]Phenyl]Amino]-4-Pyrimidinyl]Amino]Propyl]-2,2- Dimethylpropanediamide Complexed with Human PDK1
![]() Mono view ![]() Stereo pair view
Reference:
R.I.Feldman,
J.M.Wu,
M.A.Polokoff,
M.J.Kochanny,
H.Dinter,
D.Zhu,
S.L.Biroc,
B.Alicke,
J.Bryant,
S.Yuan,
B.O.Buckman,
D.Lentz,
M.Ferrer,
M.Whitlow,
M.Adler,
S.Finster,
Z.Chang,
D.O.Arnaiz.
Novel Small Molecule Inhibitors of 3-Phosphoinositide-Dependent Kinase-1. J.Biol.Chem. V. 280 19867 2005.
Page generated: Sat Jul 20 04:34:19 2024
ISSN: ISSN 0021-9258 PubMed: 15772071 DOI: 10.1074/JBC.M501367200 |
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