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Chlorine in PDB 1z6z: Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+

Enzymatic activity of Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+

All present enzymatic activity of Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+:
1.1.1.153;

Protein crystallography data

The structure of Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+, PDB code: 1z6z was solved by E.Ugochukwu, K.Kavanagh, S.Ng, C.Arrowsmith, A.Edwards, M.Sundstrom, F.Vondelft, U.Oppermann, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.10 / 2.50
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 55.274, 95.001, 162.825, 90.00, 90.57, 90.00
R / Rfree (%) 20.5 / 24.5

Chlorine Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 11;

Binding sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+ (pdb code 1z6z). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 11 binding sites of Chlorine where determined in the Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+, PDB code: 1z6z:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 11 in 1z6z

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Chlorine binding site 1 out of 11 in the Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl401

b:51.3
occ:1.00
NH2 A:ARG39 3.6 21.7 1.0
NH1 A:ARG39 3.9 19.9 1.0
O A:HOH830 4.2 26.5 1.0
CZ A:ARG39 4.2 22.7 1.0
O A:HOH831 4.3 26.0 1.0

Chlorine binding site 2 out of 11 in 1z6z

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Chlorine binding site 2 out of 11 in the Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl407

b:24.9
occ:1.00
C4N A:NAP801 3.2 20.6 1.0
OH A:TYR167 3.4 27.9 1.0
C5N A:NAP801 3.5 21.3 1.0
OG A:SER154 3.6 27.1 1.0
CE2 A:TYR167 3.7 25.0 1.0
C3N A:NAP801 3.8 20.7 1.0
CZ A:TYR167 4.0 26.6 1.0
O7N A:NAP801 4.0 24.2 1.0
C6N A:NAP801 4.3 20.5 1.0
C7N A:NAP801 4.3 21.4 1.0
CZ3 A:TRP164 4.4 26.4 1.0
SG A:CYS156 4.4 29.8 1.0
C2N A:NAP801 4.5 19.9 1.0
CB A:SER154 4.5 26.8 1.0
N1N A:NAP801 4.7 21.4 1.0
CD2 A:TYR167 4.9 25.6 1.0
CH2 A:TRP164 4.9 25.9 1.0
NE2 A:GLN203 4.9 22.1 1.0
O A:HOH845 5.0 19.7 1.0

Chlorine binding site 3 out of 11 in 1z6z

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Chlorine binding site 3 out of 11 in the Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl408

b:45.1
occ:1.00
C4N B:NAP802 3.1 25.4 1.0
C5N B:NAP802 3.4 26.3 1.0
OH B:TYR167 3.4 23.3 1.0
OG B:SER154 3.5 31.4 1.0
CE2 B:TYR167 3.8 22.8 1.0
C3N B:NAP802 3.8 26.2 1.0
CZ B:TYR167 4.0 23.8 1.0
O7N B:NAP802 4.1 27.5 1.0
C6N B:NAP802 4.2 26.1 1.0
SG B:CYS156 4.4 31.1 1.0
C7N B:NAP802 4.4 26.6 1.0
CB B:SER154 4.4 29.8 1.0
CZ3 B:TRP164 4.5 25.7 1.0
C2N B:NAP802 4.5 26.1 1.0
N1N B:NAP802 4.7 26.9 1.0
CD2 B:TYR167 4.9 22.5 1.0

Chlorine binding site 4 out of 11 in 1z6z

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Chlorine binding site 4 out of 11 in the Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl402

b:55.5
occ:1.00
O C:HOH808 3.5 26.1 1.0
NH2 C:ARG39 3.6 24.0 1.0
NH1 C:ARG39 3.7 23.0 1.0
CZ C:ARG39 4.2 23.7 1.0

Chlorine binding site 5 out of 11 in 1z6z

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Chlorine binding site 5 out of 11 in the Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl405

b:55.0
occ:1.00
N C:GLY88 3.1 30.0 1.0
CA C:GLY88 3.9 29.2 1.0
CB C:LYS87 4.0 30.8 1.0
C C:LYS87 4.0 30.5 1.0
CA C:LYS87 4.0 30.7 1.0

Chlorine binding site 6 out of 11 in 1z6z

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Chlorine binding site 6 out of 11 in the Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl406

b:35.9
occ:1.00
C4N C:NAP803 3.3 25.2 1.0
OH C:TYR167 3.3 27.3 1.0
C5N C:NAP803 3.6 26.0 1.0
CE2 C:TYR167 3.7 26.1 1.0
OG C:SER154 3.7 25.5 1.0
C3N C:NAP803 3.8 23.1 1.0
CZ C:TYR167 3.9 27.4 1.0
O7N C:NAP803 4.0 24.8 1.0
C7N C:NAP803 4.3 24.3 1.0
C6N C:NAP803 4.4 25.4 1.0
CZ3 C:TRP164 4.4 30.5 1.0
C2N C:NAP803 4.5 23.6 1.0
SG C:CYS156 4.6 29.2 1.0
CB C:SER154 4.7 25.4 1.0
N1N C:NAP803 4.7 25.1 1.0
CD2 C:TYR167 4.8 25.9 1.0
CH2 C:TRP164 4.8 29.9 1.0
NE2 C:GLN203 4.9 20.0 1.0

Chlorine binding site 7 out of 11 in 1z6z

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Chlorine binding site 7 out of 11 in the Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl403

b:45.2
occ:1.00
NH2 D:ARG39 3.4 25.0 1.0
O D:HOH811 3.7 24.9 1.0
NH1 D:ARG39 3.7 24.8 1.0
CZ D:ARG39 4.0 25.7 1.0

Chlorine binding site 8 out of 11 in 1z6z

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Chlorine binding site 8 out of 11 in the Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl409

b:61.4
occ:1.00
OH D:TYR167 3.0 23.9 1.0
C4N D:NAP804 3.2 24.1 1.0
OG D:SER154 3.2 28.5 1.0
C5N D:NAP804 3.3 24.1 1.0
CE2 D:TYR167 3.4 23.4 1.0
CZ D:TYR167 3.6 23.7 1.0
C3N D:NAP804 3.8 23.9 1.0
C6N D:NAP804 4.0 23.6 1.0
CB D:SER154 4.1 28.1 1.0
SG D:CYS156 4.3 33.1 1.0
O7N D:NAP804 4.4 21.8 1.0
C2N D:NAP804 4.4 23.9 1.0
N1N D:NAP804 4.5 24.4 1.0
C7N D:NAP804 4.5 23.3 1.0
CZ3 D:TRP164 4.6 28.7 1.0
CD2 D:TYR167 4.6 22.1 1.0
CE1 D:TYR167 4.9 23.0 1.0

Chlorine binding site 9 out of 11 in 1z6z

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Chlorine binding site 9 out of 11 in the Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl404

b:56.5
occ:1.00
NH2 E:ARG39 3.7 24.6 1.0
NH1 E:ARG39 4.1 25.9 1.0
CZ E:ARG39 4.4 25.6 1.0

Chlorine binding site 10 out of 11 in 1z6z

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Chlorine binding site 10 out of 11 in the Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Crystal Structure of Human Sepiapterin Reductase in Complex with Nadp+ within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl410

b:42.2
occ:1.00
OH E:TYR167 2.9 25.4 1.0
OG E:SER154 3.1 26.9 1.0
C4N E:NAP805 3.2 26.4 1.0
CE2 E:TYR167 3.3 23.4 1.0
C5N E:NAP805 3.3 25.2 1.0
CZ E:TYR167 3.4 24.1 1.0
C3N E:NAP805 3.9 26.8 1.0
C6N E:NAP805 3.9 26.3 1.0
CB E:SER154 4.0 27.2 1.0
SG E:CYS156 4.2 31.2 1.0
N1N E:NAP805 4.4 26.2 1.0
C2N E:NAP805 4.4 26.7 1.0
CD2 E:TYR167 4.4 23.9 1.0
O7N E:NAP805 4.5 26.8 1.0
CZ3 E:TRP164 4.6 30.7 1.0
C7N E:NAP805 4.6 26.7 1.0
CE1 E:TYR167 4.7 23.3 1.0

Reference:

E.Ugochukwu, K.Kavanagh, S.Ng, C.Arrowsmith, A.Edwards, M.Sundstrom, F.Von Delft, U.Oppermann. Crystal Structure of Human Sepiapterin Reductase To Be Published.
Page generated: Thu Jul 10 20:48:38 2025

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