Atomistry » Chlorine » PDB 1ymd-1zch » 1z9h
Atomistry »
  Chlorine »
    PDB 1ymd-1zch »
      1z9h »

Chlorine in PDB 1z9h: Microsomal Prostaglandin E Synthase Type-2

Enzymatic activity of Microsomal Prostaglandin E Synthase Type-2

All present enzymatic activity of Microsomal Prostaglandin E Synthase Type-2:
5.3.99.3;

Protein crystallography data

The structure of Microsomal Prostaglandin E Synthase Type-2, PDB code: 1z9h was solved by T.Yamada, J.Komoto, K.Watanabe, Y.Ohmiya, F.Takusagawa, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.60
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 128.240, 122.830, 111.530, 90.00, 110.60, 90.00
R / Rfree (%) 21.4 / 25.1

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Microsomal Prostaglandin E Synthase Type-2 (pdb code 1z9h). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 8 binding sites of Chlorine where determined in the Microsomal Prostaglandin E Synthase Type-2, PDB code: 1z9h:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Chlorine binding site 1 out of 8 in 1z9h

Go back to Chlorine Binding Sites List in 1z9h
Chlorine binding site 1 out of 8 in the Microsomal Prostaglandin E Synthase Type-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Microsomal Prostaglandin E Synthase Type-2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl379

b:17.6
occ:1.00
 CL A:IMN379 0.0 17.6 1.0
C13 A:IMN379 1.7 12.5 1.0
C14 A:IMN379 2.7 22.1 1.0
C12 A:IMN379 2.7 16.5 1.0
CD2 A:TYR263 3.3 13.2 1.0
CD2 A:LEU347 3.3 15.2 1.0
CE2 A:TYR263 3.5 7.0 1.0
CB A:SER260 3.5 8.4 1.0
OG A:SER260 3.6 7.8 1.0
CA A:SER260 3.7 9.0 1.0
O A:SER260 3.8 20.1 1.0
C15 A:IMN379 4.0 15.2 1.0
C11 A:IMN379 4.1 15.4 1.0
CG A:LEU347 4.1 13.3 1.0
C A:SER260 4.1 11.4 1.0
CB A:VAL250 4.4 2.0 1.0
CG1 A:ILE264 4.4 10.9 1.0
CD1 A:ILE264 4.4 6.6 1.0
CG2 A:VAL250 4.5 4.8 1.0
CG1 A:VAL250 4.6 2.0 1.0
CD1 A:LEU347 4.6 10.7 1.0
CG A:TYR263 4.6 9.6 1.0
C10 A:IMN379 4.6 12.2 1.0
O A:VAL343 4.7 13.9 1.0
CZ A:TYR263 4.8 6.7 1.0

Chlorine binding site 2 out of 8 in 1z9h

Go back to Chlorine Binding Sites List in 1z9h
Chlorine binding site 2 out of 8 in the Microsomal Prostaglandin E Synthase Type-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Microsomal Prostaglandin E Synthase Type-2 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl378

b:15.9
occ:1.00
 NH2 B:ARG137 3.4 20.8 1.0
NE B:ARG137 3.8 18.7 1.0
NH1 B:ARG146 3.8 3.0 1.0
CD B:ARG146 3.8 5.9 1.0
CZ B:ARG137 4.0 16.5 1.0
CB B:ARG146 4.5 6.7 1.0
CG B:ARG146 4.6 5.7 1.0
CZ B:ARG146 4.8 9.2 1.0
NE B:ARG146 4.8 8.1 1.0
CD B:ARG137 5.0 11.8 1.0

Chlorine binding site 3 out of 8 in 1z9h

Go back to Chlorine Binding Sites List in 1z9h
Chlorine binding site 3 out of 8 in the Microsomal Prostaglandin E Synthase Type-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Microsomal Prostaglandin E Synthase Type-2 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl380

b:10.9
occ:1.00
 OH B:TYR287 3.0 23.0 1.0
NH2 C:ARG137 3.6 27.3 1.0
CD C:ARG146 3.8 11.9 1.0
NH1 C:ARG146 3.9 2.0 1.0
NE C:ARG137 3.9 14.4 1.0
CD B:PRO254 4.2 20.4 1.0
CZ B:TYR287 4.2 15.0 1.0
CZ C:ARG137 4.2 16.9 1.0
CB C:ARG146 4.5 10.2 1.0
CE2 B:TYR287 4.5 15.7 1.0
OG1 B:THR253 4.6 22.1 1.0
CG C:ARG146 4.6 4.5 1.0
O B:ARG252 4.8 19.7 1.0
NE C:ARG146 4.8 9.1 1.0
CZ C:ARG146 4.8 4.7 1.0
CG B:PRO254 5.0 18.6 1.0

Chlorine binding site 4 out of 8 in 1z9h

Go back to Chlorine Binding Sites List in 1z9h
Chlorine binding site 4 out of 8 in the Microsomal Prostaglandin E Synthase Type-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Microsomal Prostaglandin E Synthase Type-2 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl381

b:17.6
occ:1.00
 CL B:IMN381 0.0 17.6 1.0
C13 B:IMN381 1.7 17.2 1.0
C14 B:IMN381 2.7 20.7 1.0
C12 B:IMN381 2.7 17.8 1.0
CD2 B:TYR263 3.3 24.1 1.0
CD2 B:LEU347 3.3 8.7 1.0
CE2 B:TYR263 3.4 26.9 1.0
CB B:SER260 3.5 13.6 1.0
OG B:SER260 3.6 14.9 1.0
CA B:SER260 3.7 12.8 1.0
O B:SER260 3.7 18.9 1.0
C11 B:IMN381 4.0 20.2 1.0
C15 B:IMN381 4.0 20.9 1.0
C B:SER260 4.0 11.7 1.0
CG B:LEU347 4.1 11.2 1.0
CG1 B:ILE264 4.3 9.5 1.0
CD1 B:ILE264 4.4 10.7 1.0
CB B:VAL250 4.4 2.0 1.0
CG2 B:VAL250 4.5 2.0 1.0
CG B:TYR263 4.5 24.3 1.0
CD1 B:LEU347 4.6 8.7 1.0
CG1 B:VAL250 4.6 3.1 1.0
C10 B:IMN381 4.6 18.7 1.0
O B:VAL343 4.7 4.0 1.0
CZ B:TYR263 4.8 28.8 1.0

Chlorine binding site 5 out of 8 in 1z9h

Go back to Chlorine Binding Sites List in 1z9h
Chlorine binding site 5 out of 8 in the Microsomal Prostaglandin E Synthase Type-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Microsomal Prostaglandin E Synthase Type-2 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl379

b:18.1
occ:1.00
 CL C:IMN379 0.0 18.1 1.0
C13 C:IMN379 1.7 13.5 1.0
C14 C:IMN379 2.7 19.1 1.0
C12 C:IMN379 2.7 17.1 1.0
CD2 C:TYR263 3.3 12.6 1.0
CD2 C:LEU347 3.3 19.9 1.0
CE2 C:TYR263 3.5 4.9 1.0
CB C:SER260 3.5 11.0 1.0
OG C:SER260 3.6 8.5 1.0
CA C:SER260 3.7 9.2 1.0
O C:SER260 3.8 13.1 1.0
C15 C:IMN379 4.0 17.4 1.0
C11 C:IMN379 4.1 17.3 1.0
CG C:LEU347 4.1 21.1 1.0
C C:SER260 4.1 7.7 1.0
CB C:VAL250 4.4 3.1 1.0
CG1 C:ILE264 4.4 5.2 1.0
CD1 C:ILE264 4.4 8.1 1.0
CG2 C:VAL250 4.4 7.7 1.0
CD1 C:LEU347 4.6 15.4 1.0
CG C:TYR263 4.6 12.4 1.0
CG1 C:VAL250 4.6 3.9 1.0
C10 C:IMN379 4.6 14.0 1.0
O C:VAL343 4.7 15.2 1.0
CZ C:TYR263 4.8 9.1 1.0

Chlorine binding site 6 out of 8 in 1z9h

Go back to Chlorine Binding Sites List in 1z9h
Chlorine binding site 6 out of 8 in the Microsomal Prostaglandin E Synthase Type-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Microsomal Prostaglandin E Synthase Type-2 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl378

b:13.1
occ:1.00
 OH D:TYR287 3.0 15.3 1.0
NH2 A:ARG137 3.6 21.3 1.0
CD A:ARG146 3.7 17.7 1.0
NH1 A:ARG146 3.8 7.6 1.0
NE A:ARG137 4.0 19.3 1.0
CD D:PRO254 4.2 21.0 1.0
CZ D:TYR287 4.2 14.5 1.0
CZ A:ARG137 4.3 15.6 1.0
CB A:ARG146 4.4 11.9 1.0
CG A:ARG146 4.5 12.9 1.0
CE2 D:TYR287 4.6 16.2 1.0
OG1 D:THR253 4.6 18.6 1.0
NE A:ARG146 4.6 13.2 1.0
CZ A:ARG146 4.7 9.7 1.0
O D:ARG252 4.8 18.8 1.0
CG D:PRO254 5.0 20.3 1.0

Chlorine binding site 7 out of 8 in 1z9h

Go back to Chlorine Binding Sites List in 1z9h
Chlorine binding site 7 out of 8 in the Microsomal Prostaglandin E Synthase Type-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Microsomal Prostaglandin E Synthase Type-2 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl475

b:15.6
occ:1.00
 NH2 D:ARG137 3.5 25.6 1.0
NH1 D:ARG146 3.8 2.5 1.0
NE D:ARG137 3.8 19.2 1.0
CD D:ARG146 3.8 6.0 1.0
CZ D:ARG137 4.1 17.0 1.0
CB D:ARG146 4.5 7.4 1.0
CG D:ARG146 4.6 7.5 1.0
CZ D:ARG146 4.7 5.8 1.0
NE D:ARG146 4.7 8.3 1.0
CD D:ARG137 5.0 15.2 1.0

Chlorine binding site 8 out of 8 in 1z9h

Go back to Chlorine Binding Sites List in 1z9h
Chlorine binding site 8 out of 8 in the Microsomal Prostaglandin E Synthase Type-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Microsomal Prostaglandin E Synthase Type-2 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl476

b:15.8
occ:1.00
 CL D:IMN476 0.0 15.8 1.0
C13 D:IMN476 1.7 12.8 1.0
C14 D:IMN476 2.7 17.9 1.0
C12 D:IMN476 2.7 13.0 1.0
CD2 D:TYR263 3.3 19.8 1.0
CD2 D:LEU347 3.3 14.8 1.0
CE2 D:TYR263 3.5 17.5 1.0
CB D:SER260 3.5 18.0 1.0
OG D:SER260 3.6 19.6 1.0
CA D:SER260 3.7 14.5 1.0
O D:SER260 3.7 15.0 1.0
C D:SER260 4.0 10.9 1.0
C15 D:IMN476 4.0 16.4 1.0
C11 D:IMN476 4.0 12.8 1.0
CG D:LEU347 4.1 13.4 1.0
CG1 D:ILE264 4.3 8.3 1.0
CD1 D:ILE264 4.4 8.9 1.0
CB D:VAL250 4.4 9.0 1.0
CG2 D:VAL250 4.5 5.6 1.0
CG D:TYR263 4.6 15.6 1.0
CD1 D:LEU347 4.6 10.7 1.0
C10 D:IMN476 4.6 13.1 1.0
CG1 D:VAL250 4.7 6.4 1.0
O D:VAL343 4.7 14.7 1.0
CZ D:TYR263 4.8 18.8 1.0
OH D:TYR251 5.0 40.8 1.0

Reference:

T.Yamada, J.Komoto, K.Watanabe, Y.Ohmiya, F.Takusagawa. Crystal Structure and Possible Catalytic Mechanism of Microsomal Prostaglandin E Synthase Type 2 (Mpges-2). J.Mol.Biol. V. 348 1163 2005.
ISSN: ISSN 0022-2836
PubMed: 15854652
DOI: 10.1016/J.JMB.2005.03.035
Page generated: Thu Jul 10 20:49:53 2025

Last articles

Zn in 3HXC
Zn in 3HWP
Zn in 3HW7
Zn in 3HXB
Zn in 3HUV
Zn in 3HUD
Zn in 3HSV
Zn in 3HTR
Zn in 3HT2
Zn in 3HTK
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy