Chlorine in PDB 1zjo: Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease

All present enzymatic activity of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease:
2.4.1.40;

The structure of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease, PDB code: 1zjo was solved by J.A.Letts, N.L.Rose, Y.R.Fang, C.H.Barry, S.N.Borisova, N.O.Seto, M.M.Palcic, S.V.Evans, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.64
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	52.570, 149.570, 79.390, 90.00, 90.00, 90.00
R / Rfree (%)	20.6 / 22.6

The structure of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease also contains other interesting chemical elements:

Mercury	(Hg)	5 atoms
Manganese	(Mn)	1 atom

The binding sites of Chlorine atom in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease (pdb code 1zjo). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease, PDB code: 1zjo:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl402 b:33.3 occ:1.00 CL A:CL406 2.7 27.0 1.0 OG1 A:THR119 2.8 23.3 1.0 CE1 A:PHE121 3.2 33.9 1.0 O A:HOH729 3.4 19.0 1.0 CD1 A:PHE121 3.4 32.4 1.0 O A:THR119 3.5 18.5 1.0 CB A:CYS209 3.6 19.9 1.0 CB A:THR119 3.7 17.5 1.0 HG A:HG403 3.7 30.7 0.7 C A:THR119 3.8 17.5 1.0 CA A:CYS209 4.0 17.0 1.0 N A:VAL120 4.2 17.5 1.0 N A:VAL210 4.3 16.5 1.0 O A:HOH728 4.4 27.0 1.0 CA A:VAL120 4.4 17.9 1.0 O A:VAL210 4.4 17.9 1.0 CA A:THR119 4.4 17.3 1.0 C A:CYS209 4.5 15.6 1.0 O A:HOH649 4.5 24.9 1.0 CZ A:PHE121 4.5 34.2 1.0 SG A:CYS209 4.7 26.8 1.0 C A:VAL120 4.8 19.2 1.0 CG A:PHE121 4.8 30.3 1.0 N A:PHE121 4.9 19.5 1.0 CG2 A:THR119 4.9 21.2 1.0 O A:HOH624 5.0 53.4 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose-Grease within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl406 b:27.0 occ:1.00 CL A:CL402 2.7 33.3 1.0 O A:HOH600 2.8 35.0 1.0 O A:HOH624 3.1 53.4 1.0 O A:VAL210 3.5 17.9 1.0 N A:VAL210 3.6 16.5 1.0 C A:CYS209 3.6 15.6 1.0 CB A:CYS209 3.6 19.9 1.0 C A:VAL210 3.8 17.4 1.0 O A:CYS209 4.0 14.9 1.0 CA A:VAL210 4.0 15.8 1.0 CA A:CYS209 4.0 17.0 1.0 O A:HOH649 4.0 24.9 1.0 O A:HOH729 4.2 19.0 1.0 CE2 A:PHE270 4.5 18.9 1.0 N A:ASP211 4.6 18.3 1.0 OD2 A:ASP211 4.7 24.4 1.0 O A:THR119 4.7 18.5 1.0 O A:GLY267 4.8 21.2 1.0 CD1 A:PHE121 4.9 32.4 1.0 CZ A:PHE270 4.9 18.0 1.0 OG1 A:THR119 5.0 23.3 1.0

J.A.Letts, N.L.Rose, Y.R.Fang, C.H.Barry, S.N.Borisova, N.O.Seto, M.M.Palcic, S.V.Evans. Differential Recognition of the Type I and II H Antigen Acceptors By the Human Abo(H) Blood Group A and B Glycosyltransferases. J.Biol.Chem. V. 281 3625 2006.
ISSN: ISSN 0021-9258
PubMed: 16326711
DOI: 10.1074/JBC.M507620200