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Atomistry » Chlorine » PDB 1zop-232l » 1zpc | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 1zop-232l » 1zpc » |
Chlorine in PDB 1zpc: Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-Phenyl)-2-Hydroxy- Acetylamino]-N-[4-Guanidino-1-(Thiazole-2-Carbonyl)-Butyl]- 3-Methyl-ButyramideEnzymatic activity of Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-Phenyl)-2-Hydroxy- Acetylamino]-N-[4-Guanidino-1-(Thiazole-2-Carbonyl)-Butyl]- 3-Methyl-Butyramide
All present enzymatic activity of Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-Phenyl)-2-Hydroxy- Acetylamino]-N-[4-Guanidino-1-(Thiazole-2-Carbonyl)-Butyl]- 3-Methyl-Butyramide:
3.4.21.27; Protein crystallography data
The structure of Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-Phenyl)-2-Hydroxy- Acetylamino]-N-[4-Guanidino-1-(Thiazole-2-Carbonyl)-Butyl]- 3-Methyl-Butyramide, PDB code: 1zpc
was solved by
H.Deng,
T.D.Bannister,
L.Jin,
P.Nagafuji,
C.A.Celatka,
J.Lin,
T.I.Lazarova,
M.J.Rynkiewicz,
J.Quinn,
F.Bibbins,
P.Pandey,
J.Gorga,
R.E.Babine,
H.V.Meyers,
S.S.Abdel-Meguid,
J.E.Strickler,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-Phenyl)-2-Hydroxy- Acetylamino]-N-[4-Guanidino-1-(Thiazole-2-Carbonyl)-Butyl]- 3-Methyl-Butyramide
(pdb code 1zpc). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-Phenyl)-2-Hydroxy- Acetylamino]-N-[4-Guanidino-1-(Thiazole-2-Carbonyl)-Butyl]- 3-Methyl-Butyramide, PDB code: 1zpc: Chlorine binding site 1 out of 1 in 1zpcGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-Phenyl)-2-Hydroxy- Acetylamino]-N-[4-Guanidino-1-(Thiazole-2-Carbonyl)-Butyl]- 3-Methyl-Butyramide
![]() Mono view ![]() Stereo pair view
Reference:
H.Deng,
T.D.Bannister,
L.Jin,
R.E.Babine,
J.Quinn,
P.Nagafuji,
C.A.Celatka,
J.Lin,
T.I.Lazarova,
M.J.Rynkiewicz,
F.Bibbins,
P.Pandey,
J.Gorga,
H.V.Meyers,
S.S.Abdel-Meguid,
J.E.Strickler.
Synthesis, Sar Exploration, and X-Ray Crystal Structures of Factor Xia Inhibitors Containing An Alpha-Ketothiazole Arginine Bioorg.Med.Chem.Lett. V. 16 3049 2006.
Page generated: Sat Jul 20 04:48:24 2024
ISSN: ISSN 0960-894X PubMed: 16524727 DOI: 10.1016/J.BMCL.2006.02.052 |
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