Atomistry » Chlorine » PDB 1zop-232l » 1zpk
Atomistry »
  Chlorine »
    PDB 1zop-232l »
      1zpk »

Chlorine in PDB 1zpk: Crystal Structure of the Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with A Hydroxyethylamine Peptidomimetic Inhibitor Boc-Phe- Psi[R-Ch(Oh)CH2NH]-Phe-Glu-Phe-NH2

Enzymatic activity of Crystal Structure of the Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with A Hydroxyethylamine Peptidomimetic Inhibitor Boc-Phe- Psi[R-Ch(Oh)CH2NH]-Phe-Glu-Phe-NH2

All present enzymatic activity of Crystal Structure of the Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with A Hydroxyethylamine Peptidomimetic Inhibitor Boc-Phe- Psi[R-Ch(Oh)CH2NH]-Phe-Glu-Phe-NH2:
3.4.23.16;

Protein crystallography data

The structure of Crystal Structure of the Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with A Hydroxyethylamine Peptidomimetic Inhibitor Boc-Phe- Psi[R-Ch(Oh)CH2NH]-Phe-Glu-Phe-NH2, PDB code: 1zpk was solved by J.Duskova, T.Skalova, J.Dohnalek, H.Petrokova, J.Hasek, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.65
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 62.483, 62.483, 82.412, 90.00, 90.00, 120.00
R / Rfree (%) 15.6 / 25.3

Other elements in 1zpk:

The structure of Crystal Structure of the Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with A Hydroxyethylamine Peptidomimetic Inhibitor Boc-Phe- Psi[R-Ch(Oh)CH2NH]-Phe-Glu-Phe-NH2 also contains other interesting chemical elements:

Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with A Hydroxyethylamine Peptidomimetic Inhibitor Boc-Phe- Psi[R-Ch(Oh)CH2NH]-Phe-Glu-Phe-NH2 (pdb code 1zpk). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with A Hydroxyethylamine Peptidomimetic Inhibitor Boc-Phe- Psi[R-Ch(Oh)CH2NH]-Phe-Glu-Phe-NH2, PDB code: 1zpk:

Chlorine binding site 1 out of 1 in 1zpk

Go back to Chlorine Binding Sites List in 1zpk
Chlorine binding site 1 out of 1 in the Crystal Structure of the Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with A Hydroxyethylamine Peptidomimetic Inhibitor Boc-Phe- Psi[R-Ch(Oh)CH2NH]-Phe-Glu-Phe-NH2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with A Hydroxyethylamine Peptidomimetic Inhibitor Boc-Phe- Psi[R-Ch(Oh)CH2NH]-Phe-Glu-Phe-NH2 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl501

b:48.3
occ:1.00
 N B:THR174 3.0 36.9 1.0
ND2 B:ASN188 3.2 30.8 1.0
CA B:GLY173 3.4 39.5 1.0
O B:HOH361 3.5 43.8 0.5
C B:GLY173 3.7 39.4 1.0
OG1 B:THR174 3.8 47.1 1.0
CB B:ASN188 3.8 26.5 1.0
CB B:THR174 3.9 38.2 1.0
CA B:THR174 4.0 35.8 1.0
CG B:ASN188 4.0 22.3 1.0
O B:HOH367 4.1 25.9 0.5
O B:ASN188 4.2 32.6 1.0
O B:THR174 4.5 31.9 1.0
CD2 B:LEU189 4.5 36.2 1.0
C B:ASN188 4.6 25.5 1.0
C B:THR174 4.8 32.7 1.0
CA B:ASN188 4.8 26.9 1.0
O B:ILE172 4.8 51.2 1.0
N B:GLY173 4.8 39.8 1.0
O B:GLY173 4.9 37.6 1.0
NE2 B:GLN192 4.9 56.1 1.0
NA B:NA502 5.0 49.4 1.0

Reference:

J.Duskova, T.Skalova, J.Dohnalek, H.Petrokova, J.Hasek. Mutational Study of Pseudopeptide Inhibitor Binding to Hiv-1 Protease; Analysis of Four X-Ray Structures To Be Published.
Page generated: Sat Jul 20 04:49:09 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy