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Chlorine in PDB 2chz: A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93
Enzymatic activity of A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93
All present enzymatic activity of A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93:
2.7.1.137; 2.7.1.153;
2.7.1.137; 2.7.1.153;
Protein crystallography data
The structure of A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93, PDB code: 2chz
was solved by
Z.A.Knight,
B.Gonzalez,
M.E.Feldman,
E.R.Zunder,
D.D.Goldenberg,
O.Williams,
R.Loewith,
D.Stokoe,
A.Balla,
B.Toth,
T.Balla,
W.A.Weiss,
R.L.Williams,
K.M.Shokat,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 71.80 / 2.60 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 144.025, 68.114, 106.351, 90.00, 95.21, 90.00 |
| R / Rfree (%) | 24.4 / 30.2 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93
(pdb code 2chz). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93, PDB code: 2chz:
In total only one binding site of Chlorine was determined in the A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93, PDB code: 2chz:
Chlorine binding site 1 out of 1 in 2chz
Go back to
Chlorine Binding Sites List in 2chz
Chlorine binding site 1 out
of 1 in the A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93 within 5.0Å range:
|
Reference:
Z.A.Knight,
B.Gonzalez,
M.E.Feldman,
E.R.Zunder,
D.D.Goldenberg,
O.Williams,
R.Loewith,
D.Stokoe,
A.Balla,
B.Toth,
T.Balla,
W.A.Weiss,
R.L.Williams,
K.M.Shokat.
A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling Cell(Cambridge,Mass.) V. 125 733 2006.
ISSN: ISSN 0092-8674
PubMed: 16647110
DOI: 10.1016/J.CELL.2006.03.035
Page generated: Thu Jul 10 21:45:22 2025
ISSN: ISSN 0092-8674
PubMed: 16647110
DOI: 10.1016/J.CELL.2006.03.035
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