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Atomistry » Chlorine » PDB 2cie-2dch » 2d1j » |
Chlorine in PDB 2d1j: Factor Xa in Complex with the Inhibitor 2-[[4-[(5- Chloroindol-2-Yl)Sulfonyl]Piperazin-1-Yl] Carbonyl]Thieno[3,2-B]Pyridine N-OxideEnzymatic activity of Factor Xa in Complex with the Inhibitor 2-[[4-[(5- Chloroindol-2-Yl)Sulfonyl]Piperazin-1-Yl] Carbonyl]Thieno[3,2-B]Pyridine N-Oxide
All present enzymatic activity of Factor Xa in Complex with the Inhibitor 2-[[4-[(5- Chloroindol-2-Yl)Sulfonyl]Piperazin-1-Yl] Carbonyl]Thieno[3,2-B]Pyridine N-Oxide:
3.4.21.6; Protein crystallography data
The structure of Factor Xa in Complex with the Inhibitor 2-[[4-[(5- Chloroindol-2-Yl)Sulfonyl]Piperazin-1-Yl] Carbonyl]Thieno[3,2-B]Pyridine N-Oxide, PDB code: 2d1j
was solved by
M.Suzuki,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2d1j:
The structure of Factor Xa in Complex with the Inhibitor 2-[[4-[(5- Chloroindol-2-Yl)Sulfonyl]Piperazin-1-Yl] Carbonyl]Thieno[3,2-B]Pyridine N-Oxide also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Factor Xa in Complex with the Inhibitor 2-[[4-[(5- Chloroindol-2-Yl)Sulfonyl]Piperazin-1-Yl] Carbonyl]Thieno[3,2-B]Pyridine N-Oxide
(pdb code 2d1j). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Factor Xa in Complex with the Inhibitor 2-[[4-[(5- Chloroindol-2-Yl)Sulfonyl]Piperazin-1-Yl] Carbonyl]Thieno[3,2-B]Pyridine N-Oxide, PDB code: 2d1j: Chlorine binding site 1 out of 1 in 2d1jGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Factor Xa in Complex with the Inhibitor 2-[[4-[(5- Chloroindol-2-Yl)Sulfonyl]Piperazin-1-Yl] Carbonyl]Thieno[3,2-B]Pyridine N-Oxide
![]() Mono view ![]() Stereo pair view
Reference:
S.Komoriya,
N.Haginoya,
S.Kobayashi,
T.Nagata,
A.Mochizuki,
M.Suzuki,
T.Yoshino,
H.Horino,
T.Nagahara,
M.Suzuki,
Y.Isobe,
T.Furugoori.
Design, Synthesis, and Biological Activity of Non-Basic Compounds As Factor Xa Inhibitors: Sar Study of S1 and Aryl Binding Sites. Bioorg.Med.Chem. V. 13 3927 2005.
Page generated: Sat Jul 20 06:26:15 2024
ISSN: ISSN 0968-0896 PubMed: 15911309 DOI: 10.1016/J.BMC.2005.04.006 |
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