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Atomistry » Chlorine » PDB 2dxd-2esw » 2ei6 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 2dxd-2esw » 2ei6 » |
Chlorine in PDB 2ei6: Factor Xa in Complex with the Inhibitor (-)-Cis-N1-[(5- Chloroindol-2-Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7- Tetrahydrothiazolo[5,4-C]Pyridin-2-Yl)Carbonyl]-1,2- CyclohexanediamineEnzymatic activity of Factor Xa in Complex with the Inhibitor (-)-Cis-N1-[(5- Chloroindol-2-Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7- Tetrahydrothiazolo[5,4-C]Pyridin-2-Yl)Carbonyl]-1,2- Cyclohexanediamine
All present enzymatic activity of Factor Xa in Complex with the Inhibitor (-)-Cis-N1-[(5- Chloroindol-2-Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7- Tetrahydrothiazolo[5,4-C]Pyridin-2-Yl)Carbonyl]-1,2- Cyclohexanediamine:
3.4.21.6; Protein crystallography data
The structure of Factor Xa in Complex with the Inhibitor (-)-Cis-N1-[(5- Chloroindol-2-Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7- Tetrahydrothiazolo[5,4-C]Pyridin-2-Yl)Carbonyl]-1,2- Cyclohexanediamine, PDB code: 2ei6
was solved by
M.Suzuki,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2ei6:
The structure of Factor Xa in Complex with the Inhibitor (-)-Cis-N1-[(5- Chloroindol-2-Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7- Tetrahydrothiazolo[5,4-C]Pyridin-2-Yl)Carbonyl]-1,2- Cyclohexanediamine also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Factor Xa in Complex with the Inhibitor (-)-Cis-N1-[(5- Chloroindol-2-Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7- Tetrahydrothiazolo[5,4-C]Pyridin-2-Yl)Carbonyl]-1,2- Cyclohexanediamine
(pdb code 2ei6). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Factor Xa in Complex with the Inhibitor (-)-Cis-N1-[(5- Chloroindol-2-Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7- Tetrahydrothiazolo[5,4-C]Pyridin-2-Yl)Carbonyl]-1,2- Cyclohexanediamine, PDB code: 2ei6: Chlorine binding site 1 out of 1 in 2ei6Go back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Factor Xa in Complex with the Inhibitor (-)-Cis-N1-[(5- Chloroindol-2-Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7- Tetrahydrothiazolo[5,4-C]Pyridin-2-Yl)Carbonyl]-1,2- Cyclohexanediamine
![]() Mono view ![]() Stereo pair view
Reference:
T.Nagata,
T.Yoshino,
N.Haginoya,
K.Yoshikawa,
Y.Isobe,
T.Furugohri,
H.Kanno.
Cycloalkanediamine Derivatives As Novel Blood Coagulation Factor Xa Inhibitors. Bioorg.Med.Chem.Lett. V. 17 4683 2007.
Page generated: Sat Jul 20 06:48:51 2024
ISSN: ISSN 0960-894X PubMed: 17555959 DOI: 10.1016/J.BMCL.2007.05.068 |
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