Atomistry » Chlorine » PDB 2etd-2f81 » 2evm
Atomistry »
  Chlorine »
    PDB 2etd-2f81 »
      2evm »

Chlorine in PDB 2evm: Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid

Enzymatic activity of Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid

All present enzymatic activity of Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid:
3.4.11.18;

Protein crystallography data

The structure of Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid, PDB code: 2evm was solved by W.-J.Huang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.70
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 37.800, 60.200, 50.400, 90.00, 104.50, 90.00
R / Rfree (%) 21.5 / 24.8

Other elements in 2evm:

The structure of Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid also contains other interesting chemical elements:

Manganese (Mn) 2 atoms
Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid (pdb code 2evm). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid, PDB code: 2evm:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 2evm

Go back to Chlorine Binding Sites List in 2evm
Chlorine binding site 1 out of 2 in the Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl999

b:1.3
occ:1.00
 CL1 A:FC2999 0.0 1.3 1.0
C2 A:FC2999 1.7 11.6 1.0
C3 A:FC2999 2.7 14.5 1.0
C1 A:FC2999 2.8 13.1 1.0
CG A:FC2999 3.1 12.0 1.0
CD A:FC2999 3.2 13.7 1.0
CG A:TYR65 3.5 16.7 1.0
CB A:TYR65 3.7 15.2 1.0
CD1 A:TYR65 3.8 15.7 1.0
CD2 A:TYR65 4.0 15.8 1.0
SG A:CYS70 4.0 11.7 1.0
C4 A:FC2999 4.0 15.9 1.0
C6 A:FC2999 4.1 15.2 1.0
CB A:CYS59 4.2 18.2 1.0
CE1 A:TYR65 4.4 15.7 1.0
OA A:FC2999 4.4 13.1 1.0
SG A:CYS59 4.5 20.6 1.0
CB A:FC2999 4.5 9.8 1.0
O A:CYS59 4.5 16.0 1.0
CD2 A:TYR62 4.5 22.2 1.0
C5 A:FC2999 4.6 16.9 1.0
CE2 A:TYR65 4.6 16.1 1.0
CA A:CYS59 4.6 16.1 1.0
O A:TYR62 4.6 21.8 1.0
CZ A:TYR65 4.8 18.0 1.0
CB A:TYR62 4.8 22.6 1.0
CZ3 A:TRP221 4.8 20.7 1.0
CD2 A:HIS79 4.9 13.8 1.0

Chlorine binding site 2 out of 2 in 2evm

Go back to Chlorine Binding Sites List in 2evm
Chlorine binding site 2 out of 2 in the Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl999

b:9.4
occ:1.00
 CL2 A:FC2999 0.0 9.4 1.0
C5 A:FC2999 1.7 16.9 1.0
C6 A:FC2999 2.7 15.2 1.0
C4 A:FC2999 2.7 15.9 1.0
O A:HOH1175 3.7 25.6 1.0
CD2 A:HIS63 3.8 32.7 1.0
C1 A:FC2999 4.0 13.1 1.0
NE2 A:HIS63 4.0 31.7 1.0
C3 A:FC2999 4.0 14.5 1.0
CE2 A:TYR62 4.3 23.1 1.0
CG A:HIS63 4.3 31.4 1.0
C2 A:FC2999 4.6 11.6 1.0
CE1 A:HIS63 4.7 33.1 1.0
ND1 A:HIS63 4.9 33.8 1.0
CD2 A:TYR62 4.9 22.2 1.0
CB A:HIS63 5.0 28.6 1.0
CE1 A:HIS178 5.0 20.9 1.0

Reference:

S.X.Xie, W.J.Huang, Z.Q.Ma, M.Huang, R.P.Hanzlik, Q.Z.Ye. Structural Analysis of Metalloform-Selective Inhibition of Methionine Aminopeptidase. Acta Crystallogr.,Sect.D V. 62 425 2006.
ISSN: ISSN 0907-4449
PubMed: 16552144
DOI: 10.1107/S0907444906003878
Page generated: Thu Jul 10 22:01:42 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy