Chlorine in PDB 2g6p: Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative

Enzymatic activity of Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative

All present enzymatic activity of Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative:
3.4.11.18;

Protein crystallography data

The structure of Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative, PDB code: 2g6p was solved by A.Addlagatta, X.Hu, J.O.Liu, B.W.Matthews, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	50.00 / 1.90
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	47.386, 77.522, 47.720, 90.00, 90.82, 90.00
*R / R_free (%)*	19.3 / 24.1

Other elements in 2g6p:

The structure of Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative also contains other interesting chemical elements:

Cobalt	(Co)	3 atoms
Potassium	(K)	1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative (pdb code 2g6p). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative, PDB code: 2g6p:

Chlorine binding site 1 out of 1 in 2g6p

Go back to

Chlorine Binding Sites List in 2g6p

Chlorine binding site 1 out of 1 in the Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl410 b:6.4 occ:1.00	CL1	A:HM2410	0.0	6.4	1.0
	C9	A:HM2410	1.7	25.9	1.0
	C8	A:HM2410	2.7	20.2	1.0
	C7	A:HM2410	2.7	24.8	1.0
	C18	A:HM2410	3.0	21.6	1.0
	O	A:HOH605	3.3	30.0	1.0
	N4	A:HM2410	3.4	31.9	1.0
	O	A:HOH613	3.6	41.8	1.0
	CD2	A:HIS310	3.7	21.5	1.0
	CG	A:HIS310	3.9	24.9	1.0
	N3	A:HM2410	4.0	23.4	1.0
	N2	A:HM2410	4.1	30.3	1.0
	CB	A:HIS310	4.1	20.0	1.0
	NE2	A:HIS310	4.4	22.4	1.0
	C6	A:HM2410	4.5	15.4	1.0
	C17	A:HM2410	4.5	41.3	1.0
	ND1	A:HIS310	4.7	19.9	1.0
	C10	A:HM2410	4.8	30.3	1.0
	CE1	A:HIS310	4.9	23.6	1.0
	O	A:CYS301	5.0	22.1	1.0

Reference:

X.Hu, A.Addlagatta, B.W.Matthews, J.O.Liu. Identification of Pyridinylpyrimidines As Inhibitors of Human Methionine Aminopeptidases. Angew.Chem.Int.Ed.Engl. V. 45 3772 2006.
ISSN: ISSN 1433-7851
PubMed: 16724298
DOI: 10.1002/ANIE.200600757

Page generated: Thu Jul 10 22:18:06 2025

Last articles

Fe in 5TH5
Fe in 5T5M
Fe in 5TIA
Fe in 5TI9
Fe in 5TGS
Fe in 5TFU
Fe in 5TG0
Fe in 5TFT
Fe in 5TE8
Fe in 5TDV

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy