Chlorine in PDB 2gm9: Structure of Rabbit Muscle Glycogen Phosphorylase in Complex with Thienopyrrole

All present enzymatic activity of Structure of Rabbit Muscle Glycogen Phosphorylase in Complex with Thienopyrrole:
2.4.1.1;

The structure of Structure of Rabbit Muscle Glycogen Phosphorylase in Complex with Thienopyrrole, PDB code: 2gm9 was solved by L.R.Otterbein, A.D.Pannifer, J.Tucker, J.Breed, N.G.Oikonomakos, C.Minshull, S.Rowsell, R.A.Pauptit, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	91.29 / 2.30
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	126.781, 126.781, 115.144, 90.00, 90.00, 90.00
R / Rfree (%)	18.2 / 24.5

The binding sites of Chlorine atom in the Structure of Rabbit Muscle Glycogen Phosphorylase in Complex with Thienopyrrole (pdb code 2gm9). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Rabbit Muscle Glycogen Phosphorylase in Complex with Thienopyrrole, PDB code: 2gm9:

Chlorine binding site 1 out of 1 in the Structure of Rabbit Muscle Glycogen Phosphorylase in Complex with Thienopyrrole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Rabbit Muscle Glycogen Phosphorylase in Complex with Thienopyrrole within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1 b:50.7 occ:1.00 CL A:3TH1 0.0 50.7 1.0 C2 A:3TH1 1.7 50.7 1.0 C3 A:3TH1 2.8 49.9 1.0 S10 A:3TH1 3.0 49.8 1.0 CE3 A:TRP67 3.5 25.8 1.0 CG A:ARG60 3.5 29.4 1.0 CZ3 A:TRP67 3.6 26.2 1.0 CG A:PRO229 3.8 25.1 1.0 CG2 A:VAL64 3.9 29.9 1.0 O A:ARG60 3.9 27.2 1.0 C4 A:3TH1 4.0 50.4 1.0 C9 A:3TH1 4.1 48.6 1.0 CB A:LEU63 4.1 27.3 1.0 CD A:ARG60 4.2 31.4 1.0 CD1 A:LEU63 4.4 31.5 1.0 CB A:PRO229 4.5 25.5 1.0 CD A:PRO229 4.6 25.1 1.0 CD2 A:TRP67 4.7 24.6 1.0 N A:VAL64 4.7 27.3 1.0 C A:ARG60 4.8 27.6 1.0 CA A:VAL64 4.8 28.0 1.0 CH2 A:TRP67 4.8 25.2 1.0 O A:TRP189 4.8 35.9 1.0 NE A:ARG60 4.8 34.2 1.0 CB A:ARG60 4.9 28.5 1.0 CG A:LEU63 4.9 29.1 1.0 C A:LEU63 5.0 27.3 1.0 CB A:VAL64 5.0 28.5 1.0

P.R.Whittamore, M.S.Addie, S.N.Bennett, A.M.Birch, M.Butters, L.Godfrey, P.W.Kenny, A.D.Morley, P.M.Murray, N.G.Oikonomakos, L.R.Otterbein, A.D.Pannifer, J.S.Parker, K.Readman, P.S.Siedlecki, P.Schofield, A.Stocker, M.J.Taylor, L.A.Townsend, D.P.Whalley, J.Whitehouse. Novel Thienopyrrole Glycogen Phosphorylase Inhibitors: Synthesis, in Vitro Sar and Crystallographic Studies. Bioorg.Med.Chem.Lett. V. 16 5567 2006.
ISSN: ISSN 0960-894X
PubMed: 16945526
DOI: 10.1016/J.BMCL.2006.08.047